Allergy & Asthma

123 Pages·09.28 MB·English

EUROPEAN COMMISSION
Allergy & Asthma
EU Research Projects synopsis
Key Action 1 - Key Action 4
Fifth Framework programme
1998-2002
Directorate-General for Research
2004 Qol-Quality of life and management of living resources EUR 21219
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TABLE OF CONTENTS

Introduction………………………………………………………………………….III

DG RTD contacts in Asthma & Allergy.…………...………….................................IV

Index of funded projects by Key Actions of the Thematic Programme ,
“Quality of life and management of living resources”................……………...….V

Project synopsis.....……………………………………………… .……………...p.001

Index of funded projects by project number.....………………………………...p.104

Index by project co-ordinators.....……………………………………………..... p.107

Index by project participants.....……………………………………………… ...p.108

Participation by countries…………………………………………………..…… .p.114

II
Introduction

The aim of this publication is to give an overview of the projects in the area of Allergy and
Asthma financed under the Fifth Research Framework Programme. It presents abstracts and
progress reports of each project funded under Key Action 1-FOOD, NUTRITION AND
HEALTH (Food Allergy) and Key Action 4-ENVIRONMENT AND HEALTH (Allergy and
Asthma).

Allergy and asthma are two major diseases that negatively impact the quality of life of
Europeans. They are the 6th leading cause of chronic diseases and have escalated the health
care costs to over 18 billion Euros per year.

During the Fifth Research Framework Programme, the European Commission contribution
for Allergy and Asthma Research, increased considerably to 45 million Euros. As shown in
this catalogue the research projects funded cover a wide range of factors involved in allergies
and asthma, from food allergy to cosmetics allergies. The different focus of the projects varies
from the hygiene hypothesis, started in Europe in the 80’s and now spread worldwide, to
different environmental factors, diet or lifestyle, etc..

The commitment has continued in the Sixth Research Framework Programme. In FP6 we
have now funded a Network of Excellence in Allergy and Asthma- GA2LEN comprising 27
partners, including EAACI ( European Academy of Allergology and Clinical Immunology)
and EFA ( European Federation of Asthma and Allergy Associations), from 16 countries.
This Network is designed to strengthen scientific and technological excellence in allergy and
asthma in the European Research Area (ERA).

The aim of this European Commission funded research is aim to fight against these diseases,
improving at the same time the quality of life of the people in Europe suffering from allergies
or asthma.
We hope this publication will help to disseminate the results of these projects and will be used
by both general and specialist readers.
We are particularly grateful to the project co-ordinators and participants who helped us
making this catalogue, they are the ones providing the answers.
III
QUALITY OF LIVE “ALLERGY & ASTHMA”

DG RESEARCH CONTACTS

DIRECTOR: CHRISTIAN PATERMANN
[email protected]
Tel : [phone]

ACTING HEAD OF UNIT: CALLUM SEARLE
Tel : [phone]

RESPONSIBLE FOR ASTHMA & ALLERGY : ANA NIETO NUEZ
Tel : [phone]

TEAM

CALLUM SEARLE [email protected]
Tel : [phone]

MINNA WILKKI [email protected]
Tel : [phone]

TUOMO KARJALAINEN [email protected]
Tel : [phone]

ANA NIETO NUEZ ana.nieto @cec.eu.int
Tel : [phone]

Secretarial and logistic support

LILIANA MUNGIOLI [email protected]
Tel : [phone]

NADEGE BASTIAENEN [email protected]
Tel : [phone]

Mailing address:

European Commission SDME 08 – 21 B – 1049 Brussels
Tel: + 32 2 298 78 04 Fax : + 32 2 296 43 22
E-mail: [email protected]
Editor: Ana Nieto Nuez

Catalogue prepared by Liliana Mungioli and Nadège Bastiaenen
IV
INDEX OF FUNDED PROJECTS BY KEY ACTIONS OF THE THEMATIC
PROGRAMME “QUALITY OF LIFE AND MANAGEMENT OF LIVING
RESOURCES”

1) KEY ACTION 1- FOOD, NUTRITION AND HEALTH
FOOD ALLERGY

QLK1-2000-01394
Plant Food Allergies: Field To Table Strategies For Reducing Their Incidence In Europe
(SAFE) …………..……………………………………………………………………………….p.39

QLK1-2001-01151
Development Of Rapid Easy-To-Use Immunochemical Tests For The Detection Of Proteins With
Allergenic Potential In Food
(ALLERGENTEST) …………………………………………………………………………….p.66

QLK1-2001-01239
The Effect of Gastrointestinal Digestion on the Allergenicity of Foods
(ALLERGEST) ………………………………………………………………………………….p.71

QLK1-2001-02284
Communicating about Food Allergies - Information for Consumers, Regulators and Industry
(INFORMALL) ………………………………………………………………………………….p.78

QLK4-2002-02606
Effect of diet and lifestyle on risk of gastrointestinal infection and allergy in early life; consumer
knowledge, attitudes and needs
(INFABIO) …………………………………………………………………………………...….p.96

QLK1-2002-02687
Reduced allergenicity of processed foods (CONTAINING ANIMAL ALLERGENS)
(REDALL) …………………………………………………………………………………….p.101

2) KEY ACTION 4- ENVIRONMENT AND HEALTH
ALLERGY AND ASTHMA

QLK4-1999-01237
European prospective study of environment, allergy and the lung
(ECHRS II) …………………………………………………………………………………….….p.6

QLK4-1999-01288
Prevalence and determinants of Childhodd asthma and allergies across Europe
(PDCAAE) ……………………………………………………………………………………….p.11

V
QLK4-1999-01391
Prevention of allergy – risk factors for sensitisation in children related to farming and
anthroposophic lifestyle
(PARSIFAL) …………………………………………………………………………………….p.15

QLK4-1999-01558
Fragrance chemical allergy: a major environmental and consumer health problem in Europe
(FRAGRANCE ALLERGY) …………………………………………………………………...p.17

QLK4-2000-00073
Effects of outdoor and indoor air pollution on the development of allergic disease in children
(AIRALLERG) ………………………………………………………………………………….p.23

QLK4-2000-00263
Environmental influences and infection as aetiological agencies in atopy and asthma in young
children
(E2I-4AYC) ……………………………………………………………………………..……….p.25

QLK4-2000-00279
Placental Uptake and Transfer of Environmental Chemicals Relating to Allergy in Childhood Years
(PLUTOCRACY) ……………………………………………………………………………...p.28

QLK4-2000-00538
Impact of intestinal microflora on allergy development
(ALLERGYFLORA) …………………………………………………………………………..p.33

QLK4-2000-00787
A new technology for fluorescent “cell chip” immunotoxicity testing
(IMMUNOTEX CELL CHIP) …………………………………………………...…………….p.35

QLK4-2000-00792
Respiratory allergy and inflammation due to ambient particles – A European-wide assessment
(RAIAP) ………………………………………………………………………………………….p.37

QLK4-2001-00115
Allergy to the sun: Multidisciplinary investigation on the pathogenesis, treatment and prevention of
Polymorphic Light Eruption across Europe
(SUNALL) ……………………………………………………………………………………….p.42

QLK4-2001-00250
Protection against Allergy: Study in Rural Environments
(PASTURE) ………………………………………………………………………..…………….p.45

QLK4-2001-00301
Food Allergy Risk Evaluation based on improved Diagnosis, Allergens and Test methods
(FAREDAT) ………………………………………………………………………………….….p.49

QLK4-2001-00343
European Surveillance System on Contact Allergies – Data Centre
(ESSCA-DC) …………………………………………………………………………………….p.53

VI
QLK4-2001-00366
The Role of Chemokines in the Pathogenesis of Atopic Eczema
(Chemokines-Atopy) …………………………………………………………………………….p.56

QLK4-2001-00432
Measurement of Occupational Allergen Exposure
(MOCALEX) …………………………………………………………………………………….p.59

3) OTHER RELATED PROJECTS

QLK4-1999-00927
Molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco
smoke.
(GEN-AIR) …………………………………………………………………………………….….p.2

QLK4-1999-01308
Biomarkers for the non-invasive assessment of acute and chronic effects f air pollutants on the
respiratory epithelium development and application to adults and children along north-south
gradient
(HELIOS) …………………………………………………………….………………………….p.13

QLK4-1999-01582
Health effects of particles from motor engine exhaust and ambient air pollution - a European
collaborative project
(HEPMEAP) …………………………………………………………………………………….p.21

QLK4-2001-00441
A Thematic Network on Air Pollution and Health
(AIRNET) ……………………………………………………………………………………….p.63

QLK4-2001-02357
Multidisciplinary approach to airborne pollutant health related issues: Modelization with
combustion engine exhausts
(MAAPHRI) ……………………………………………………………………………….…….p.87

QLK4-2001-02544
Pollution and the Young: Combined analyses of cross-sectional studies of respiratory health of children and
air pollution
(PATY) ………………………………………………………………………………………...….p.89

QLK4-2002-02395
Policy Interpretation Network on Children's Health and Environment
(PINCHE) ……………………………………………………………………………….....…….p.92

VII
PROJECT SYNOPSIS
MOLECULAR CHANGES AND GENETIC SUSCEPTIBILITY IN RELATION TO AIR
POLLUTION AND ENVIRONMENTAL TOBACCO SMOKE: A CASE-CONTROL
STUDY IN NON-SMOKERS NESTED IN THE EPIC INVESTIGATION (GEN – AIR)

Contract N° QLK4-1999-00927 Project type Shared Cost
Project cost € 1.116.060 EC contribution € 1.116.060
Project duration 36 Months Project start date 01/04/2000
Call closing date: 8 June 1999

EC Scientific Officer: Tuomo KARJALAINEN

Co-ordinator:

Prof. Paolo VINEIS
University of Torino, Department of Biomedical Sciences and Human Oncology,
Via Santena 7
IT- 10126, Torino
Italy
Tel: [phone]; Fax: [phone]
[email protected]

Partners:

Dr Alison DUNNING Dr Michal KRZYZANOWSKI
University of Cambridge World Health Organization
Department of Oncology European Centre for Environment and Health
Addenbrooke’s Hospital Bilthoven Division
Hills Road, Box 193 P.O. Box 10
UK-CB2 2QQ Cambridge A.van Leeuwenhoeklaan 9
United Kingdom NL- 3730 AA , De Bilt
Tel: [phone]; Fax: [phone] The Netherlands
[email protected] Tel: [phone]; Fax: [phone]
[email protected]

Dr Elio RIBOLI Dr Antonello PROVENZALE
International Agency for Research on Cancer Fondazione I.S.I.
Unit of Mechanisms of Carcinogenesis Viale Settimio Severo 65
Cours Albert Thomas 150 IT-10133 Torino
FR-69372 Lyon Italy
France Tel: [phone]; Fax: [phone]
Tel: [phone]; Fax: [phone] [email protected]
[email protected]

Dr Giuseppe MATULLO Dr Marco PELUSO
Universita’ di Torino Istituto Nazionale per la Ricerca sul Cancro
Dipartimento di Genetica, Biologia e Biochimica Servizio di Oncologia Sperimentale
Via Santena 19 Largo Rosanna Benzi 10
IT- 10126 Torino IT-16132 Genova
Italy Italy
Tel: [phone]; Fax:[phone] Tel: [phone]; Fax: [phone]
[email protected] [email protected]

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