Allergy and Respiration

94 Pages·2016·2.14 MB·English

by  Mieczyslaw Pokorski (eds.)

Advances in Experimental Medicine and Biology 921
Neuroscience and Respiration
Mieczyslaw Pokorski Editor
Allergy and
Respiration
Advances in Experimental Medicine
and Biology
Neuroscience and Respiration
Volume 921
Editorial Board
Irun R. Cohen, The Weizmann Institute of Science, Rehovot, Israel
N.S.AbelLajtha,KlineInstituteforPsychiatricResearch,Orangeburg,NY,USA
John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA
Rodolfo Paoletti, University of Milan, Milan, Italy
Subseries Editor
Mieczyslaw Pokorski
More information about this series at http://www.springer.com/series/13457
Mieczyslaw Pokorski
Editor
Allergy and Respiration
Editor
MieczyslawPokorski
PublicHigherMedicalProfessionalSchoolinOpole
InstituteofNursing
Opole,Poland
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISBN978-3-319-42003-5 ISBN978-3-319-42004-2 (eBook)
DOI10.1007/978-3-319-42004-2
LibraryofCongressControlNumber:2016948845
#SpringerInternationalPublishingSwitzerland2016
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Preface
The book series Neuroscience and Respiration presents contributions by
expert researchers and clinicians in the field of pulmonary disorders. The
chapters provide timely overviews of contentious issues or recent advances
in the diagnosis, classification, and treatment of the entire range of pulmo-
narydisorders,bothacuteandchronic.Thetextsarethoughtasamergerof
basic and clinical research dealing with respiratory medicine, neural and
chemical regulation of respiration, and the interactive relationship between
respiration and other neurobiological systems such as cardiovascular func-
tionorthemind-to-bodyconnection.Theauthorsfocusontheleading-edge
therapeutic concepts, methodologies, and innovative treatments. Pharmaco-
therapy is always in the focus of respiratory research. The action and
pharmacology of existing drugs and the development and evaluation of
new agents are the heady area of research. Practical, data-driven options to
manage patients will be considered. New research is presented regarding
older drugs, performed from a modern perspective or from a different
pharmacotherapeutic angle. The introduction of new drugs and treatment
approachesinbothadultsandchildrenalsoisdiscussed.
Lung ventilation is ultimately driven by the brain. However, neuropsy-
chologicalaspectsofrespiratorydisordersarestillmostlyamatterofconjec-
ture. After decades of misunderstanding and neglect, emotions have been
rediscovered as a powerful modifier or even the probable cause of various
somatic disorders. Today, the link between stress and respiratory health is
undeniable. Scientists accept a powerful psychological connection that can
directlyaffectourqualityoflifeandhealthspan.Psychologicalapproaches,
bydecreasingstress,canplayamajorroleinthedevelopmentandtherapyof
respiratorydiseases.
Neuromolecular aspects relating to gene polymorphism and epigenesis,
involvingbothheritablechangesinthenucleotidesequenceandfunctionally
relevantchangestothegenomethatdonotinvolveachangeinthenucleotide
sequence, leading to respiratory disorders will also be tackled. Clinical
advancesstemmingfrommolecularandbiochemicalresearcharebutpossi-
ble if the research findings are translated into diagnostic tools, therapeutic
procedures,andeducation,effectivelyreachingphysiciansandpatients.All
thatcannotbeachievedwithoutamultidisciplinary,collaborative,bench-to-
bedsideapproachinvolvingbothresearchersandclinicians.
v
vi Preface
Thesocietalandeconomicburdenofrespiratoryailmentshasbeenonthe
rise worldwide leading to disabilities and shortening of life span. COPD
alone causes more than three million deaths globally each year. Concerted
efforts are required to improve this situation, and part of those efforts are
gaining insights into the underlying mechanisms of disease and staying
abreast with the latest developments in diagnosis and treatment regimens.
Itishopedthatthebookspublishedinthisserieswillassumealeadingrolein
the field of respiratory medicine and research and will become a source of
referenceandinspirationforfutureresearchideas.
I would like to express my deep gratitude to Mr. Martijn Roelandse and
Ms. Tanja Koppejan from Springer’s Life Sciences Department for their
genuineinterestinmakingthisscientificendeavorcomethroughandinthe
expertmanagementoftheproductionofthisnovelbookseries.
Opole,Poland MieczyslawPokorski
Contents
SpirometryorBodyPlethysmographyfortheAssessment
ofBronchialHyperresponsiveness?.. . . . . . .. . . . . . .. . . . . . .. . . 1
R.Merget,F.Nensa,E.Heinze,D.Taeger,andT.Bruening
ClinicalEffects,ExhaledBreathCondensatepH
andExhaledNitricOxideinHumansAfterEthyl
AcrylateExposure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
F.Hoffmeyer,J.Bünger,C.Monse´,H.Berresheim,B.Jettkant,
A.Beine,T.Brüning,andK.Sucker
EffectivenessofPCRandImmunofluorescenceTechniques
forDetectingHumanCytomegalovirusinBlood
andBronchoalveolarLavageFluid. . . . . . . . . . . . . . . . . . . . . . . . . 21
A.Roz˙y,K.Duk,B.Szumna,P.Skron´ska,D.Gawryluk,and
J.Chorostowska-Wynimko
TheRoleofIonChannelstoRegulateAirwayCiliary
BeatFrequencyDuringAllergicInflammation. . . . . . . . . . . . . . . . 27
M. Joskova,M.Sutovska, P.Durdik, D. Koniar,L.Hargas,
P.Banovcin,M.Hrianka,V.Khazaei,L.Pappova,andS.Franova
ContentofAsthmagenNaturalRubberLatexAllergens
inCommercialDisposableGloves. . . . . . . . . . . . . . . . . . . . . . . . . . 37
C.Bittner,M.V.Garrido,L.H.Krach,andV.Harth
ThermalSensitivityandDimethylSulfoxide(DMSO). . . . . . . . . . . 45
KotaroTakeda,MieczyslawPokorski,andYasumasaOkada
IgEReactivity,WorkRelatedAllergicSymptoms,
AsthmaSeverity,andQualityofLifeinBakerswith
OccupationalAsthma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
C.Bittner,M.V.Garrido,V.Harth,andA.M.Preisser
EffectsofSelectiveInhibitionofPDE4byYM976onAirway
ReactivityandCoughinOvalbumin-SensitizedGuineaPigs. . . . . 61
J.Mokry´,A.Urbanova´,I.Medvedova´,M.Kertys,P.Mikolka,
P.Kosutova´,andD.Mokra´
vii
viii Contents
AirwayDefenseControlMediatedvia Voltage-Gated
SodiumChannels. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
M.Kocmalova,M.Joskova,S.Franova,P.Banovcin,
andM.Sutovska
VirologicalCharacteristicsofthe2014/2015Influenza
SeasonBasedonMolecularAnalysisofBiologicalMaterial
DerivedfromI-MOVEStudy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
E.Hallmann-Szelin´ska,K.Bednarska,M.Korczyn´ska,
I.Paradowska-Stankiewicz,andL.B.Brydak
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . 87
AdvsExp.Medicine,Biology-NeuroscienceandRespiration(2016)24:1–10
DOI10.1007/5584_2015_204
#SpringerInternationalPublishingSwitzerland2015
Publishedonline:29January2016
Spirometry or Body Plethysmography
for the Assessment of Bronchial
Hyperresponsiveness?
R. Merget, F. Nensa, E. Heinze, D. Taeger, and T. Bruening
Abstract
Methacholinetestingisoneofthestandardtoolsforthediagnosisofmild
asthma,butthereislittleinformationaboutoptimaloutcomemeasures.In
thisstudyatotalof395collegestudentsweretestedbytheATSdosimeter
protocol for methacholine testing, with minor modification. Body
plethysmography and spirometry were measured after each inhalation
step. The end-of-test-criteria were (i) decrease in forced expiratory vol-
ume in 1 s (FEV ) of (cid:1) 20 % and (ii) doubling of specific airway
1
resistanceand itsincreaseto(cid:1)2.0kPa∙s.Theresultswere expressed by
receiveroperatingcharacteristic(ROC)plotsusingquestionnaireanswers
asareference.TheareasundertheROCcurveswereiterativelycalculated
for a wide range of thresholds for both measures. We found that ROC
plots showed maximal sensitivities of about 0.5–0.6 for FEV and about
1
0.7 for specific airway conductance (sGt), with similar specificities of
about 0.7–0.8 taking questions with the known high specificity as
references. Accordingly, larger maximal areas under the ROC curve
were observed for body plethysmography, but the differences were
small.AdecreaseinFEV ofabout15%andadecreaseofsGtofabout
1
60%showedthelargestareasundertheROCcurves.Inconclusion,body
plethysmography yielded better sensitivity than spirometry, with similar
specificity. However, replacing the common spirometric criterium for a
positivetest(20%decreaseinFEV frombaseline)bytheoptimalbody
1
plethysmographic criterium would result in an increase of false positive
testsfromabout4to8%inhealthyyoungadults.
R.Merget(*),F.Nensa,E.Heinze,D.Taeger,and
T.Bruening
InstituteforPreventionandOccupationalMedicineofthe
GermanSocialAccidentInsurance,InstituteoftheRuhr
University,1Bu¨rkle-de-la-Camp-Platz,44789Bochum
(IPA),Germany
e-mail:[email protected]
1