Contents iii Contents VOLUME 20 NUMBER 1 Ist JULY Review article: targeted screening for hereditary Risk of vascular disease in adults with diagnosed haemochromatosis in high-risk groups. S. DuBois coeliac disease: a population-based study. J. West, & K. V. Kowdley R. F. A. Logan, T. R. Card, C. Smith & R. Hubbard Treatment of acute hepatitis C with interferon «-2b: Pathophysiological characteristics of patients with early initiation of treatment is the most effective pre- non-erosive reflux disease differ from those of patients dictive factor of sustained viral response. J. Delwaide, with functional heartburn. M. Frazzoni, E. De Micheli, N. Bourgeois, C. Gérard, S. De Maeght, F. Mokaddem, P. Zentilin & V. Savarino E. Wain, B. Bastens, J. Fevery, M. Géhénot, O. Le Moine, The Visceral Sensitivity Index: development and J. P. Martinet, G. Robaeys, B. Servais, M. Van Gossum, validation of a gastrointestinal symptom-specific H. Van Vlierberghe & The Belgian Associatiofno r the Study anxiety scale. J. §. Labus, R. Bolus, L. Chang, I. Wiklund, of the Liver (BASL) J. Naesdal, E. A. Mayer & B. D. Naliboff Metformin in the treatment of non-alcoholic steatohe- Seven-day therapy for Helicobacter pylori in the United patitis: a pilot open label trial. §. Nair, A. M. Diehl, States. N. Vakil, F. Lanza, H. Schwartz & J. Barth M. Wiseman, G. H. Farr Jr & R. P. Perrillo '5¢-ethanol breath test reveals impaired alcohol Pharmacokinetic variations of acetaminophen metabolism in patients with Helicobacter pylori according to liver dysfunction and portal hypertension infection. M. Suzuki, K. Maruyama, H. Suzuki, S. Tanaki, status. P. Zapater, M. C. Lasso de la Vega, J. F. Horga, K. Suzuki & H. Ishii J. Such, R. Frances, A. Esteban, J]. M. Palazon, F. Carnicer, Masking of '*C urea breath test by proton pump S. Pascual & M. Pérez-Mateo inhibitors is dependent on type of medication: Pegylated interferon-x2a kinetics during experimental comparison between omeprazole, pantoprazole, haemodialysis: impact of permeability and pore size of lansoprazole and esomeprazole. A. Levine, O. Shevah, dialysers. G. Barril, J. A. Quiroga, P. Sanz, F. Rodriguez- V. Shabat-Sehayek, H. Aeed, M. Boaz, S. F. Moss, Y. Niv, Salvanés, R. Selgas & V. Carrerio Y. Avni & H. Shirin Clinical and histological features of non-alcoholic fatty Letter to the Editors liver disease in Hong Kong Chinese. V. W.-S. Wong, Pegylated interferon-x-2b monotherapy for H. L.-Y. Chan, A. Y. Hui, K.-F. Chan, C.-T. Liew, haemodialysis patients with chronic hepatitis F. K.-L. Chan & J. J.-Y. Sung C. B. E. Annicchiaroco & M. SicilianoB. E. Annichiarico Therapeutic Arthritis Research and Gastrointestinal & M. Siciliano Event Trial of lumiracoxib — study design and patient Author's reply: F. Fabrizi & P. Martin demographics. C. J. Hawkey, M. Farkouh, X. Gitton, The treatment algorithm instead of the unknown E. Ehrsam, J. Huels & P. Richardson optimal dose of botulinum toxin for chronic anal Azathioprine dose escalation in inflammatory bowel fissure. M. Madalinski disease. C. K. Rayner, A. L. Hart, C. M. M. Hayward, Author’s reply: G. Brisinda, F. Cadeddu, A. Mabisombi A. V. Emmanuel & M. A. Kamm & G. Maria iv Contents VOLUME 20 NUMBER 2. 151TH JULY Review article: hepatitis C virus-related extra-hepatic The cost-effectiveness of high-dose oral proton pump disease — aetiopathogenesis and management. inhibition after endoscopy in the acute treatment of ]. Medina, L. Garcta-Buey & R. Moreno-Otero peptic ulcer bleeding. A. N. Barkun, K. Herba, V. Adam, Systematic review: how effective are the usual W. Kennedy, C. A. Fallone & M. Bardou treatments for ulcerative colitis? J. R. Bebb Risks of interleukin-1 genetic polymorphisms and & B. B. Scott Helicobacter pylori infection in the development of Systematic review: how effective are the usual gastric cancer. A. Chen, C.-N. Li, P.-I. Hsu, K.-H. Lai, treatments for Crohn's disease? J. R. Bebb & B. B. Scott H.-H. Tseng, P.-N. Hsu, G.-H. Lo, C.-C. Lo, C.-K. Lin, Efficacy and safety of thiopurinic immunomodulators L.-R. Hwang, Y. Yamaoka & H.-C. Chen (azathioprine and mercaptopurine) in steroid-depen- The effects of withdrawing tegaserod treatment in dent ulcerative colitis. A. Lopez-Sanroman, F. Bermejo, comparison with continuous treatment in irritable E. Carrera & A. Garcia-Plaza bowel syndrome patients with abdominal pain/dis- Improvement in quality of life of children with acute comfort, bloating and constipation: a clinical study. Crohn’s disease does not parallel mucosal healing after K. D. Bardhan, A. Forbes, C. L. Marsden, T. Mason treatment with exclusive enteral nutrition. N. A. Afzal, & G. Short H. J. van der Zaag-Loonen, F. Arnaud-Battandier, Alosetron repeat dose pharmacokinetics, effects on S. Davies, S. Murch, B. Derkx, R. Heuschkel & J. M. Fell enzyme activities, and influence of demographic Hyperamylasaemia and acute pancreatitis in factors. K. M. Koch, B. W. Corrigan, J. Manzo, paracetamol poisoning. L. E. Schmidt & K. Dalhoff C. D. James, R. J. Scott, A. G. Stead & K. E. Kersey Six-month trial of on-demand rabeprazole 10 mg Anti-ganglioside antibodies in children with coeliac maintains symptom relief in patients with non-erosive disease: correlation with gluten-free diet and reflux disease. P. Bytzer, A. Blum, D. De Herdt neurological complications. C. Briani, S. Ruggero, & D. Dubois, on behalf of the trial investigators G. Zara, E. Toffanin, M. Ermani, C. Betterle & G. Guariso Wireless capsule endoscopy in patients with obscure Effect of asimadoline, a « opioid agonist, on pain gastrointestinal bleeding: a comparative study with induced by colonic distension in patients with irritable push enteroscopy. A. Mata, J. M. Bordas, F. Feu, bowel syndrome. M. Delvaux, A. Beck, J. Jacob, A. Ginés, M. Pellisé, G. Fernandez-Esparrach, F. Balaguer, H. Bouzamondo, F. T. Weber & J. Frexinos J. M. Pique & J. Llach Letter to the Editors. F. Ozgeng, B. Dikici & R. V. Yagci Contents v VOLUME 20 NUMBER 3 lst AUGUST Review article: the evolving role of liver biopsy. Health-related quality of life of patients with M. S. Campbell & K. R. Reddy gastrointestinal symptoms. H. J. Bovenschen, Review article: Helicobacter pylori and molecular events R. J. F. Laheij, A. C. I. T. L. Tan, E. M. Witteman, in precancerous gastric lesions. G. Nardone, A. Rocco L. G. M. van Rossum & J. B. M. J. Jansen & P. Malfertheiner Economic analysis of strategies in the prevention of Review article: hepatic hydrothorax. A. Cardenas, non-steroidal anti-inflammatory drug-induced T. Kelleher & S. Chopra complications in the gastrointestinal tract. A. Lanas Four years of treatment with lamivudine: clinical and Effect of the motilin agonist KC 11458 on gastric virological evaluations in HBe antigen-negative chronic emptying in diabetic gastroparesis. A. Russo, hepatitis B. §. Gaia, A. Marzano, A. Smedile, V. Barbon, J. E. Stevens, N. Giles, G. Krause, D. G. O'Donovan, M. L. Abate, A. Olivero, M. Lagget, S. Paganin, M. Fadda, M. Horowitz & K. L. Jones G. Niro & M. Rizzetto Prevalence of irritable bowel syndrome according to Increased thrombin generation and circulating levels of different diagnostic criteria in a non-selected adult tumour necrosis factor-x in patients with chronic population. M. T. Hillilad & M. A. Farkkild Helicobacter pylori-positive gastritis. A. Consolazio, In vivo evaluation of a novel pH- and time-based M. C. Borgia, D. Ferro, F. lacopini, O. A. Paoluzi, multiunit colonic drug delivery system. C. Bott, P. Crispino, F. Nardi, M. Rivera & P. Paoluzi M. W. Rudolph, A. R. J. Schneider, S. Schirrmacher, Helicobacter pylori eradication in children and B. Skalsky, H.-U. Petereit, P. Langguth, J. B. Dressman adolescents by a once daily 6-day treatment with or & J. Stein without a proton pump inhibitor in a double-blind A new questionnaire for constipation and faecal randomized trial. Y. Tindberg, T. H. Casswall, incontinence. A. E. Bharucha, G. R. Locke III, B. M. Seide M. Blennow, C. Bengtsson, M. Granstrém & M. Sérberg & A. R. Zinsmeister Tumour necrosis factor-« receptor 1 and 2 Reproducibility of a symptom response to omeprazole polymorphisms in inflammatory bowel disease and therapy in functional dyspepsia evaluated by a their association with response to infliximab. M. Pierik, random-starting-day trial design. L. G. Madsen S. Vermeire, K. V. Steen, S. Joossens, G. Claessens, & P. Bytzer R. Vlietinck & P. Rutgeerts vi Contents VOLUME 20 NUMBER 4 15TH AUGUST Systematic review: the hepatotoxicity of non-steroidal Erythropoietin increases platelet reactivity and platelet anti-inflammatory drugs. J. H. Rubenstein & L. Laine counts in patients with alcoholic liver cirrhosis: Personal view: ‘Don’t ask, don’t tell’ — the undesirable a randomized, double-blind, placebo-controlled study. consequences of incidental test results in M. Homoncik, P. Jilma-Stohlawetz, M. Schmid, gastroenterology. A. Sonnenberg A. Ferlitsch & M. Peck-Radosavljevic Personal view: rationale and proposed algorithms for 5 The impact of immigration on the increasing incidence symptom-based proton pump inhibitor therapy for of hepatocellular carcinoma in the United States. gastro-oesophageal reflux disease. P. Bytzer K. Kulkarni, E. Barcak, H. El-Serag & R. Goodgame & A. L. Blum Treatment of gastro-oesophageal reflux disease with Intragastric acid suppression and pharmacokinetics of rabeprazole in primary and secondary care: does twice-daily esomeprazole: a randomized, three-way Helicobacter pylori infection affect proton pump inhibitor crossover study. P. O. Katz, D. O. Castell, Y. Chen, effectiveness? N. J. Wit, W. A. de Boer, H. Geldof, T. Andersson & M. B. Sostek B. Hazelhoff, P. Bergmans, G. N. J. Tytgat A novel option in proton pump inhibitor dosing: & A. J. P. M. Smout lansoprazole orally disintegrating tablet dispersed in The validity and accuracy of the Work Productivity and water and administered via nasogastric tube. Activity Impairment questionnaire — irritable bowel J]. W. Freston, M. J. Kukulka, E. Lloyd & C. Lee syndrome version (WPAI:IBS). M. C. Reilly, A. Bracco, The role of acid suppression in patients with endoscopy- J.-F. Ricci, J. Santoro & T. Stevens negative reflux disease: the effect of treatment with A rapid immunochromatographic assay for Helicobacter esomeprazole or omeprazole. D. Armstrong, N. J. Talley, pylori in stool before and after treatment. K. Lauritsen, B. Moum, T. Lind, H. Tunturi-Hihnala, T. L. Gatta, F. Perna, C. Ricci, J. F. Osborn, A. Tampieri, Venables, J. Green, M. A. Bigard, J. Méssner & O. Junghard V. Bernabucci, M. Miglioli & D. Vaira Identifying response to acid suppressive therapy in Successful treatment of oesophageal candidiasis by functional dyspepsia using a random starting day micafungin: a novel systemic antifungal agent. trial — is gastro-oesophageal reflux important? K. Pettengell, J. Mynharat, T. Kluyts, W. Lau, D. Fack- L. G. Madsen, L. Wallin & P. Bytzer lam& D. Buell, the FK463 South African study group Pneumatic balloon dilatation in achalasia: a prospective comparison of safety and efficacy with different balloon diameters. J. Mikaeli, F. Bishehsari, G. Montazeri, M. Yaghoobi & R. Malekzadeh Contents vii VOLUME 20 NUMBER 5 Ist SEPTEMBER Systematic review: has disease outcome in Crohn's Fracture risk of women with primary biliary cirrhosis: disease changed during the last four decades? no increase compared with general population controls. F. L. Wolters, M. G. V. M. Russel & R. W. Stockbrtigger J. R. Boulton-Jones, R. M. F. Fenn, J. West, Relationship between body mass index, diet, exercise R. F. A. Logan & S. D. Ryder and gastro-oesophageal reflux symptoms in a Helicobacter pylori infection prevents the occurrence of community. §. Nandurkar, G. R. Locke III, S. Fett, the tolerance phenomenon of histamine H2 receptor A. R. Zinsmeister, A. J. Cameron & N. J. Talley antagonists. T. Fujisawa, K. Adachi, Y. Komazawa, Projections of demand and capacity for colonoscopy T. Mihara, T. Azumi, T. Katsube, K. Furuta, H. Kazumori related to increasing rates of colorectal cancer & Y. Kinoshita screening in the United States. S. Vijan, J. Inadomi, 7 Prevention of erosive oesophagitis relapse with R. A. Hayward, T. P. Hofer & A. M. Fendrick pantoprazole. J. E. Richter, P. Fraga, M. Mack, Effect of acid on duodenal blood flow and mucus S. M. Sabesin W. Bochenek & the Pantoprazole US GERD secretion measured by reflectance spectrophotometry: Study Group a prospective, randomized-controlled study. Use of anti-secretory medication: a population-based F. C. Ramirez, J. F. Holland, J. Harker & F. W. Leung cohort study. A. Lassen, J. Hallas & O. B. Schaffalitzky de Reduced incidence of upper gastrointestinal ulcer Muckadell complications with the COX-2 selective inhibitor, Basic fibroblast growth factor as a response parameter valdecoxib. J. L. Goldstein, G. M. Eisen, N. Agrawal, to infliximab in fistulizing Crohn’s disease. Q. Gao, W. F. Stenson, J. D. Kent & K. M. Verburg R. A. van Hogezand, C. B. H. W. Lamers Adjuvant biofeedback following anal sphincter repair: & H. W. Verspaget a randomized study. K. J. Davis, D. Kumar & J. Poloniecki Contents VOLUME 20 NUMBER 6 15TH SEPTEMBER Cost-effectiveness of thiopurine methyltransferase Esomeprazole 20 mg on-demand is more acceptable to genotype screening in patients about to commence patients than continuous lansoprazole 15 mg in the azathioprine therapy for treatment of inflammatory long-term maintenance of endoscopy-negative gastro- bowel disease J. Winter, A. Walker, D. Shapiro, oesophageal reflux patients: the COMMAND Study. D. Gaffney, R. J. Spooner & P. R. Mills H. H. Tsai, R. Chapman, A. Shepherd, D. McKeith, Azathioprine formulation optimizes metabolite profile M. Anderson, D. Vearer, S. Duggan & J. P. Rosen in inflammatory bowel disease T. Stevens, J. P. Achkar, Long-term outcome and objective changes of anorectal K. Easley, A. Brzezinski & B. Lashner function after biofeedback therapy for faecal incon- Rapid improvement of bone metabolism after infliximab tinence R. Ozturk, S. Niazi, M. Stessman & S. S. C. Rao treatment in Crohn’s disease N. Franchimont, Effect of cyclo-oxygenase inhibitors on Helicobacter V. Putzeys, J. Collette, S. Vermeire, P. Rutgeerts, pylori susceptibility to metronidazole and clari- M. De Vos, A. Van Gossum, D. Franchimont, R. Fiasse, thromycin Q. Gu, H. H.-X. Xia, W. H. Wang, J. D. Wang, P. Pelckmans, M. Malaise, ]. Belaiche & E. Louis W. M. Wong, A. O. O. Chan, M. F. Yuen, S. K. Lam, 5 Diagnostic accuracy of faecal calprotectin estimation in H. K.-L. Cheung, X. G. Liu & B. C.-Y. Wong prediction of abnormal small bowel radiology Effects of effervescent ranitidine on gastric pH: S. Dolwani, M. Metzner, J. J. Wassell, A. Yong comparison with almagate and placebo in fasting and & A. B. Hawthorne postprandial conditions E. Rey, C. Poves-Francés, A pilot study of orlistat treatment in obese, non-alco- G. Sanchez, A. Fueyo, C. Badiola & M. Diaz-Rubio holic steatohepatitis patients S. A. Harrison, C. Fincke, D. Differential effects of two types of antidepressants, Helinski, S. Torgerson & P. Hayashi amitriptyline and fluoxetine, on anorectal motility and Combination therapy for the treatment of hepatitis C in visceral perception L. Siproudhis, M. Dinasquet, the veteran population: higher than expected rates of V. Sébille, J. M. Reymann & E. Bellissant therapy discontinuation Y. Getachew, J. D. Browning, Letters to the Editors M. Prebis, T. Rogers & G. R. Brown Epidemiology of ischaemic colitis A. Brinker 7 Oesophageal and gastric pH profiles in patients with & M. Avigan gastro-oesophageal reflux disease and Barrett's Author’s reply L. Laine & P. D. R. Higgins oesophagus treated with proton pump inhibitors L. Corrigenda B. Gerson, V. Boparai, N. Ullah & G. Triadafilopoulos Erratum Daily use of non-steroidal anti-inflammatory drugs is less frequent in patients with Barrett’s oesophagus who develop an oesophageal adenocarcinoma P. Tsibouris, M. T. Hendrickse & P. E. T. Isaacs Contents ix VOLUME 20 NUMBER 7 1st OCTOBER Systematic review: geographical and ethnic differences Barrett's oesophagus with predominant intestinal in gastro-oesophageal reflux disease. J. Y. Kang metaplasia correlates with superficial cyclo-oxygenase- Review article: the role of the hiatus hernia in 2 expression, increased proliferation and reduced gastro-oesophageal reflux disease. C. Gordon, J. Y. Kang, apoptosis: changes that are partially reversed by P. J. Neild & J. D. Maxwell non-steroidal anti-inflammatory drugs usage. Systematic review: the effect of Helicobacter pylori and Y. Amano, S. Ishihara, Y. Kushiyama, T. Yuki, its eradication on gastro-oesophageal reflux disease in Y. Takahashi, D. Chinuki, T. Miyake, Y. Miyaoka, patients with duodenal ulcers or reflux oesophagitis. M. A. K. Rumi, N. Ishimura, K. Adachi & Y. Kinoshita A. S. Raghunath, A. P. S. Hungin, D. Wooff & S. Childs Onset and disappearance of reflux symptoms in a Meta-analysis: budesonide treatment for collagenous Chinese population: a 1-year follow-up study. colitis. B. Feyen, G. C. Wall, E. P. Finnerty, J. E. DeWitt W. M. Wong, K. C. Lai, K. F. Lam, W. M. Hui, & R. S. Reyes J]. Q. Huang, H. H. X. Xia, W. H. C. Hu, C. L. K. Lam, Natural history of gastro-oesophageal reflux disease C. K. Chan, S. K. Lam & B. C. Y. Wong diagnosed in general practice. A. Ruigomez, L. A. Garcia Intestinal inflammation is a frequent feature of cystic Rodriguez, M.-A. Wallander, S. Johansson, H. Graffner fibrosis and is reduced by probiotic administration. & J. Dent E. Bruzzese, V. Raia, G. Gaudiello, G. Polito, There is no difference in the disease severity of gastro- V. Buccigrossi, V. Formicola & A. Guarino oesophageal reflux disease between patients infected Letter to the Editors and not infected with Helicobacter pylori. C. A. Fallone, Gluten-related cerebral hypoperfusion and neurologic A. N. Barkun, S. Mayrand, G. Wakil, G. Friedman, disorders in coeliac patients. L. Leggio, L. Abenavoli, A. Szilagyi, C. Wheeler & D. Ross C. D'Angelo, D. Di Giuda, G. Gasbarrini & G. Addolorato Risk of malignancy in diagnosed coeliac disease: Reply C. Birani a 24-year prospective, population-based, cohort study. Anti-Saccharomyces cerevisiae antibodies and response T. R. Card, ]. West & G. K. T. Holmes to infliximab in refractory Crohn's disease. O. Schréder, Psychological support counselling improves gluten-free M. Naumann & J. Stein diet compliance in coeliac patients with affective disorders. G, Addolorato, G. De Lorenzi, L. Abenavoli, L. Leggio, E. Capristo & G. Gasbarrini Granulocyte and monocyte adsorptive apheresis in the treatment of active distal ulcerative colitis: a prospective, pilot study. T. Yamamoto, S. Umegae, T. Kitagawa, Y. Yasuda, Y. Yamada, D. Takahashi, M. Mukumoto, N. Nishimura, K. Yasue & K. Matsumoto x Contents VOLUME 20 NUMBER 8 15TH OCTOBER Review article: Pegylated interferons: chemical and Dwell time and functional failure in percutaneous clinical differences. G. R. Foster endoscopic gastrostomy tubes: a prospective Review article: therapeutic roles of acupuncture in randomized-controlled comparison between silicon functional gastrointestinal disorders. H. Ouyang polymer and polyurethane percutaneous endoscopic & J. D. Z. Chen gastrostomy tubes. J. Blacka, J]. Donoghue, M. Sutherland, Increased incidence of azathioprine-induced pancreati- I. Martincich, S. Mitten-Lewis, P. Morris & G. Meredith tis in Crohn’s disease compared with other diseases. Intravenous and oral lansoprazole are equivalent in R. K. Weersma, F. T. M. Peters, L. E. Oostenbrug, suppressing stimulated acid output in patient A. P. van den Berg, M. van Haastert, R. J. Ploeg, volunteers with erosive oesophagitis. T. O. G. Kovacs, M. D. Posthumus, J. J. Homan van der Heide, C. QO. Lee, Y.-L. Chiu, B. L. Pilmer & D. C. Metz P. L. M. Jansen & H. M. van Dullemen International validation of ReQuest in patients with Effect of antitumour necrosis factor-% therapy on bone endoscopy-negative gastro-oesophageal reflux disease. turnover in patients with active Crohn’s disease: K. D. Bardhan, V. Stanghellini, D. Armstrong, a prospective study. B. M. Ryan, M. G. V. M. Russel, P. Berghéfer, G. Gatz & H. Ménnikes L. Schurgers, M. Wichers, J. Sijbrandij, R. W. Stockbrugger 899 Effect of low-dose rabeprazole and omeprazole on & E. Schoon gastric acidity: results of a double blind, randomized, Nicotine enemas for treatment of ulcerative colitis: placebo-controlled, three-way crossover study in a study of the pharmacokinetics and adverse events healthy subjects. S. Bruley des Varannes, H. Gharib, associated with three doses of nicotine. J. R. Ingram, V. Bicheler, R. Bost, B. Bonaz, L. Stanescu, J. C. Delchier P. Routledge, J. Rhodes, R. W. Marshall, D. C. Buss, & S. Bonnot-Marlier B. K. Evans, C. Feyerabend & G. A. O. Thomas 909 Non-cardiac chest pain: predictors of health care Treatment of Budd-Chiari syndrome in a Liver seeking, the types of health care professional consulted, Transplant Unit, the role of transjugular intrahepatic work absenteeism and interruption of daily activities. porto-systemic shunt and liver transplantation. G. D. Eslick & N. J. Talley A. Attwell, M. Ludkowski, R. Nash & M. Kugelmas Contents xi Contents VOLUME 20 NUMBER 9 Ist NOVEMBER Review article: the management of side-effects during Sleep dysfunction in patients with gastro-oesophageal therapy for hepatitis C. R. J. Aspinall & P. J. Pockros reflux disease: prevalence and response to GERD ther- Meta-analysis: a randomized trial of peginterferon plus apy, a pilot study. N. Chand, D. A. Johnson, M. Tabangin ribavirin for the initial treatment of chronic hepatitis C & J. C. Ware genotype 4. M. S. Khuroo, M. S. Khuroo & S. T. Dahab A single dose of ranitidine 150 mg modulates Personal view: cost and benefit of medical rituals in oesophageal acid sensitivity in patients with functional gastroenterology. A. Sonnenberg heartburn. S. Rodriguez-Stanley, A. A. Ciociola, A prospective, randomized-controlled pilot study of S. Zubaidi, H. M. Proskin & P. B. Miner Jr ursodeoxycholic acid combined with mycophenolate The new DR-70 immunoassay detects cancer of the mofetil in the treatment of primary sclerosing gastrointestinal tract: a validation study. A. Kerber, cholangitis. R. K. Sterling, J. J. Salvatori, V. A. Luketic, J. Trojan, K. Herrlinger, D. Zgouras, W. F. Caspary A. J. Sanyal, A. S. Fulcher, R. T. Stravitz, M. J. Contos, & B. Braden A. S. Mills & M. L. Shiffman Are patients’ sedation preferences at gastroscopy Rapid hip bone loss in active Crohn’s disease patients influenced by preceding patients’ decisions? . receiving short-term corticosteroid therapy. J. H. Tobias, A. Olithselvan, A. S. McIntyre & D. A. Gorard M. R. Sasi, R. Greenwood & C. S. J. Probert Behaviour of the bowel wall during the first year after surgery is a strong predictor of symptomatic recurrence of Crohn’s disease: a prospective study. F. Parente, G. M. Sampietro, M. Molteni, S. Greco, A. Anderloni, C. Sposito, P. G. Danelli, A. M. Taschieri, S. Gallus & G. Bianchi Porro xii Contents VOLUME 20 NUMBER 10° 15TH NOVEMBER Review article: current status of liver transplantation in system. L. Rabeneck, J. A. Davila, M. Thompson HIV-infected patients. G. W. Neff, K. E. Sherman, & H. B. El-Serag B. Eghtesad & J. Fung Clinical experience of patients undergoing 1001 Review article: '*C-urea breath test in the diagnosis of photodynamic therapy for Barrett’s dysplasia or cancer. Helicobacter pylori infection. J. P. Gisbert & J. M. Pajares H. C. Wolfsen, L. L. Hemminger, M. B. Wallace 1019 Review article: orofacial granulomatosis. J. C. Ledo, & K. R. DeVault T. Hodgson, C. Scully & S. Porter Randomized placebo-controlled trial assessing the effect 1029 Review article: is there a link between micronutrient of bifidobacteria-fermented milk on active ulcerative malnutrition and Helicobacter pylori infection?. colitis. K. Kato, S. Mizuno, Y. Umesaki, Y. Ishii, J. Salgueiro, M. Zubillaga, C. Goldman, A. Barrado, M. Sugitani, A. Imaoka, M. Otsuka, O. Hasunuma, M. Martinez Sarrasague, N. Leonardi & J. Boccio R. Kurihara, A. Iwasaki & Y. Arakawa A systematic review: Is ingestion of paracetamol or Anti-Saccharomyces cerevisiae mannan antibodies in non-steroidal anti-inflammatory drugs associated with inflammatory bowel disease: comparison of different exacerbations of inflammatory bowel disease? assays and correlation with clinical features. V. Annese, K. Forrest, D. Symmons & P. Foster A. Piepoli, F. Perri, G. Lombardi, A. Latiano, Meta-analysis: the diagnostic value of alarm symptoms G. Napolitano, G. Corritore, P. Vandewalle, D. Poulain, for upper gastrointestinal malignancy. G. A. J. Fransen, J. F. Colombel & A. Andriulli M. J. R. Janssen, J. W. M. Muris, R. J. P. Laheij Symptomatic gastro-oesophageal reflux, arousals and & J. B. M. J. Jansen sleep quality in patients undergoing polysomnography Meta-analysis: the effect of age on immunological for possible obstructive sleep apnoea. N. Guda, response to hepatitis B vaccine in end-stage renal S. Partington & N. Vakil disease. F. Fabrizi, P. Martin, V. Dixit, S. Bunnapradist Do physicians correctly assess patient symptom severity & G. Dulai in gastro-oesophageal reflux disease? C. A. Fallone, 1063 Meta-analysis: the detection of pancreatic malignancy G. H. Guyatt, D. Armstrong, I. Wiklund, A. Degl'Innocenti, with positron emission tomography. L. A. Orlando, D. Heels-Ansdell, A. N. Barkun, N. Chiba, S. J. O. van S. L. Kulasingam & D. B. Matchar Zanten, S. El-Dika, P. Austin, L. Tanser Meta-analysis: the efficacy, adverse events, and & H. J. Schtinemann adherence related to first-line anti-Helicobacter pylori Classification of dyspepsia and response to treatment quadruple therapies. L. A. Fischbach, S. V. van Zanten with proton-pump inhibitors. V. Meineche-Schmidt & J. Dickason Bacillus clausii therapy to reduce side-effects of anti- A novel diagnostic tool for detecting oesophageal Helicobacter pylori treatment: randomized, double-blind, pathology: the PillCam oesophageal video capsule. placebo controlled trial. E. C. Nista, M. Candelli, R. Eliakim, K. Yassin, I. Shlomi, A. Suissa & G. M. Eisen F. Cremonini, I. A. Cazzato, M. A. Zocco, F. Franceschi, 1091 Proton-pump inhibitors reduce the risk of G. Cammarota, G. Gasbarrini & A. Gasbarrini uncomplicated peptic ulcer in elderly either acute or High-dose vitamin E supplementation does not chronic users of aspirin/non-steroidal anti-inflam- diminish ribavirin-associated haemolysis in hepatitis C matory drugs. A. Pilotto, M. Franceschi, G. 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