Table Of Content

VOLUME 6. NUMBER 1 . FEBRUARY 1992 1 A letter from the Editors. R. Es POUNDER & W. L. PETERSON 3 Review article: maintenance treatment with H,-receptor antagonists for peptic ulcer disease. J.G. PENSTON & K.G. WORMSLEY 31 A Eudragit-coated prednisolone preparation for ulcerative colitis: pharmacokinetics and preliminary therapeutic use. G. A.F ORD, P.S. OLIVER, N. A. SHEPHERD & S.P. WILKINSON Inhibition of human exocrine pancreatic secretion by the long-acting somatostatin analogue octreotide (SMS 201-995). T. PD. KEMMER, P. MALFERTHEINER, M. BUCHLER, H. FRIESS, L. MESCHEN MOSER & H. DITSCHUNEIT Clinical tolerance to three 5-aminosalicylic acid releasing preparations in patients with inflammatory bowel disease intolerant or allergic to sulphasalazine. M. H. GIAFFER, C.J. O’BRIEN & C.D. HOLDSWORTH f-Galactosidase from Aspergillus niger in adult lactose malabsorption: a double-blind crossover study. G.R. CORAZZA, G. BENATI, M. SORGE, A. STROCCHI, G. CALZA & G. GASBARRINI A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats. R. MELARANGE, G. MOORE, P.R. BLOWER, M. E. COATES, F. W. WARD & V. RONAASEN The in-vitro mucosal conjunction of ethinyloestradiol and the bioavailability of oral contraceptive steroids in patients with treated and untreated coeliac disease. S. F. M.GRIMMER, D. J. BACK, M. L’E. ORME, J. F. TJIA, I. T.G ILMORE & A. ELLIS Lansoprazole versus famotidine: efficacy and tolerance in the acute management of duodenal ulceration. J. HOTZ, R. KLEINERT, T. GRYMBOWSKI, U. HENNIG &J.A.SCHWARZ Comparison of one-day oral dosing with three bismuth compounds for the suppression of Helicobacter pylori assessed by the '3C-urea breath test. E. J. PREWETT, Y. W. LUK, A. G. FRASER, W. M. LAM & R. E. POUNDER Omeprazole (20 mg) daily given in the morning or evening: a comparison of effects on gastric acidity, and plasma gastrin and omeprazole concentration. S.G. CHIVERTON, C. W. HOWDEN, D. W. BURGET & R. H. HUNT Short report: short-term triple therapy for H. pylori-associated duodenal ulcer disease. S. PATCHETT, S. BEATTIE, C. KEANE &C. O’MORAIN Helicobacter pylori clearance in the treatment of non-ulcer dyspepsia. C. HOLCOMBE, C. THOM, J. KALUBA &S. B. LUCAS VOLUME 6. NUMBER 2. APRIL 1992 125 Review article: adrenergic control of motor and secretory function in the gastrointestinal tract. A.S. MCINTYRE & D.G. THOMPSON 143 Review article: non-steroidal, anti-inflammatory drugs — the extending scope of gastrointestinal side effects. L. AABAKKEN 163 Verapamil inhibits in-vitro leucotriene B4 release by rectal mucosa in active ulcerative colitis. D. J. GERTNER, D.S. RAMPTON, T. R. J. STEVENS & J. E. LENNARD-JONES 169 Helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion. G. P. YOUNG, N. STEMMENT, A. LASTOVICA, E.L. VAN DEN MERWE, J. A. LOUW,I. M. MODLIN &IL.N. MARKS 179 Compliance with anti-ulcer medication during short-term healing phase clinical trials. P.G. FARUP 187 Circadian differences in pharmacological blockade of meal-stimulated gastric acid secretion. S. W. SANDERS, J.G. MOORE, G. M. DAY & K.G. TOLMAN 195 Effect of acute and chronic acid suppression on plasma gastrin release in the rat. C.-C. SCHUERER-MALY, W. KROMER, B. FLOGERZI, L. VARGA, S. POSTIUS & F. HALTER 207 Cholestasis in transplant patients — what is the role of cyclosporin. R. E. BLUHM, W. H. RODGERS, D. L. BLACK, G. R. WILKINSON & R. A. BRANCH 221 Effect of treatment with cisapride alone or in combination with domperidone on gastric emptying and gastrointestinal symptoms in dyspeptic patients. M.T ATSUTA, H. IISHI, A.NAKAIZUMI&S.OKUDA 229 Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo- controlled trial. S.U DEN, D. SCHOFIELD, P. F. MILLER, J. P. DAY, T. BOTTIGLIER &J.M. BRAGANZA 241 Comparison of plasma bismuth levels after oral dosing with basic bismuth carbonate or tripotassium dicitrato bismuthate. S. MADAUS, E.SCHULTE-FROHLINDE, C. SCHERER, A. KAMMEREIT, V.SCHUSDZIARRA & M. CLASSEN 257 Sucralfate diminishes basal acid output without affecting gastrin, H. pylori or gastritis in duodenal ulcer patients. S. F.M OSS, D. M. THOMAS, K. AYESU,S. LEVI &J.CALAM 299 A pharmacokinetic study of sulphasalazine and two new formulations of mesalazine. G. L. SWIFT, C. M. MILLS, J. RHODES, B. K. EVANS, A. BENNETT & I. A. TAVARES 267 Short report: the effect of ranitidine on the post-prandial absorption of a low dose of alcohol. A. G. FRASER, M. HUDSON, A. M. SAWYERR, S. B. ROSALKI & R. E. POUNDER VOLUME 6 . NUMBER 3 . JUNE 1992 273 Review article: 5-hydroxytryp*amine agonists and antagonists in the modulation of gastrointestinal motility and sensation — clinical implications. N. J. TALLEY 291 Review article: the treatment of Helicobacter pylori infection. R. V. HEATLEY 305 Effects of acetorphan, an antidiarrhoeal enkephalinase inhibitor, on oro-caecal and colonic transit times in healthy volunteers. J. F. BERGMANN, S. CHAUSSADE, D. COUTURIER, P. BAUMER, J.C. SCHWARTZ &J.M. LECOMTE 315 The long-term management of duodenal ulceration using an H>-antagonist: symptomatic self-care compared with maintenance treatment. R. E.P OUNDER, H. FESTEN & M. KORMAN 327 Does a previous course of tripotassium dicitrato bismuthate affect the subsequent chances of successful Helicobacter pylori eradication? G. D. BELL. K. POWELL, S. M. BURRIDGE, G. HARRISON, J. WEIL, P. W. GANT, P. H. JONES & J. E. TROWELL 335 Effects on the rat oxyntic mucosa of the histamine-antagonist loxtidine and the Ht, K+-ATPase inhibitor omeprazole. E. BRENNA, H.L.WALDUM, A. K.SANDVIK, B. SCHULZE SOGNEN & A. KRISTENSEN 351 Pharmacokinetics and absolute rectal bioavailability of hydrocortisone acetate in distal colitis.O. PETITJEAN, J. L.W ENDLING, M. TOD, K. LOUCHAHI, P. NICOLAS, G. PERRET & A. ASTIER 359 The effects of lansoprazole, a new H+,Kt-ATPase inhibitor, on gastric pH and serum gastrin. S. W.S ANDERS, K.G. TOLMAN, P. A. GRESKI, D. E. JENNINGS, P. A. HOYOS &J.G. PAGE 373 Effects of oral pantoprazole on 24-hour intragastric acidity and plasma gastrin profiles. A.H ANNAN, J. WEIL, C. BROOM & R. P. WALT 381 Night-time or morning dosing with H>-receptor antagonists: studies on acid inhibition in normal subjects. N. PATEL, U. WARD, M. J. ROGERS &J. N. PRIMROSE 389 Short report: twenty-four-hour hyperpepsinogenaemia in Helicobacter pylori-positive subjects is abolished by eradication of the infection. A.G. FRASER, E. J. PREWETT, R. E. POUNDER & |. M.SAMLOFF 395 Correspondence. J. WEIL, G. D. BELL & K. POWELL VOLUME 6. NUMBER 4 . AUGUST 1992 399 Review article: metabolic consequences of long-term inhibition of acid secretion by omeprazole. H.K OOP 407 Effect of potassium chloride on gastric acid secretion and gastrin release in humans. M. FELDMAN & M. GOLDSCHMIEDT 415 The effect of alpha-1-adrenoreceptor agonist and antagonist administration on human upper gastrointestinal transit and motility. A.S. McINTYRE, D.G. THOMPSON, W. R. BURNHAM & E. WALKER 427 Experience with ‘triple’ anti-Helicobacter pylori eradication therapy: side-effects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance. G. D. BELL, K. POWELL, S. M. BURRIDGE, A. PALLECAROS, P. H. JONES, P. W. GANT, G. HARRISON &J. E. TROWELL 437 Co-administration of misoprostol or ranitidine with indomethacin: effects on pharmacokinetics, abdominal symptoms and bowel habit. M. J. KENDALL, R. GIBSON & R. P. WALT 447 An artificial stomach — duodenum model for the in-vitro evaluation of antacids. J. VATIER, E. MALIKOVA-SEKERA, M. T. VITRE & M. MIGNON 459 Oral pharmacokinetics of cyclosporin in patients with primary biliary cirrhosis and patients with skin diseases. R. BEUKERS,S. DE RAVE,J.W.O. VAN DEN BERG &S.W.SCHALM 469 Omeprazole versus famotidine in the short-term treatment of duodenal ulcer disease. G. DELLE FAVE, B. ANNIBALE, M. FRANCESCHI, M. QUATRINI, M.R. CASSETTA & A. TORSOLI 479 Improved maintenance of remission in ulcerative colitis by balsalazide 4g/day compared with 2g /day. M. H. GIAFFER, C. D.H OLDSWORTH, J. E. LENNARD-JONES, C. A. RODRIGUES, P. B. McINTYRE, S. MANJUNATHA, J. H. BARON, |. G. BARRISON, R. J. POLSON, A.M. HOARE,G.S.R. DAVIES & P.C. THORNTON 487 Influence of the timing of administration of 300 mg ranitidine on 24-hour gastric pH in patients with acute duodenal ulcer. A.C ORTOT, F. GUILLEMOT, J. MOREAU, J.C. SOULE, M. VEYRAC, B. ALBEROLA & M. PAPPO 495 Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. E. LANGHOLZ, J. BRYNSKOV, K. BENDTZEN, M. VILIEN & V. BINDER 503 Short report: cefprozil for the eradication of Helicobacter pylori infection. H. MALATY, P. D. KLEIN & D. Y. GRAHAM 507 Short report: comparison of the effects of sublingual nifedipine and isosorbide dinitrate on oesophageal emptying in patients with Chagasic achalasia. M.C. A. FIGUEIREDO, R. B. OLIVEIRA, N. IAZIGI& N.M. MATSUDA 513 Short report: comparison of two orally administered bowel preparations for colonoscopy — polyethylene glycol and sodium picosulphate. M. DAKKAK, K. AZIZ &J.R. BENNETT VOLUME 6. NUMBER 5. OCTOBER 1992 521 Review article: the pathophysiology and pharmacological treatment of portal hypertension. R. D.G ROSE & P.C. HAYES 541 Review article: the treatment of alcoholic liver disease. L. Ma.B LENDIS 549 Comparison between a standard pancreatic supplement and a high enzyme preparation in cystic fibrosis. G.M ORRISON, J. M. MORRISON, A. O. B. REDMOND,C. A. BYERS, K. H. McCRACKEN, J. A. DODGE &S. A.GUILFORD 557 The effect of H2-blockade on plasma gastrin concentration in patients with an achlorhydric stomach. G.M. FULLARTON, J. E.S. ARDILL & K. E. L. McCOLL 565 Omeprazole in the long-term treatment of severe gastro-oesophageal reflux disease in patients with systemic sclerosis. L. HENDEL, E. HAGE, J. HENDEL & P.STENTOFT 579 A comparison of gastro-oesophageal reflux in volunteers assessed by ambulatory pH and gamma monitoring after treatment with either Liquid Gaviscon or Algicon Suspension. N. WASHINGTON, J. L. GREAVES &S. Y. IFTIKHAR 589 Oral or intravenous erythromycin has no effect on human distal colonic motility. J.S. JAMESON, J. ROGERS, J.J. MISIEWICZ, A.H. RAIMUNDO & M. M. HENRY 597 Ranitidine for erosive oesophagitis: a double-blind, placebo-controlled study. W. ROUFAIL, A. BELSITO, M. ROBINSON, C. BARISH, A. RUBIN & GLAXO EROSIVE ESOPHAGITIS STUDY GROUP 609 The effect of combined therapy with ranitidine and pirenzepine in the treatment of reflux oesophagitis. W.L ONDONG, J. PHILLIPS, N. J. JOHNSON &J.R. WOOD 619 A new model of human secretory diarrhoea using cholera toxin. J. B. HUNT, A. V. THILLAINAYAGAM, S. CARNABY, P. D. FAIRCLOUGH, M.L. CLARK &M.J.G. FARTHING 629 Nine years of maintenance treatment with ranitidine for patients with duodenal ulcer disease. J.G. PENSTON & K.G. WORMSLEY 647 Short report: comparison of two doses of balsalazide in maintaining ulcerative colitis in remission over 12 months. J. R. B.G REEN, C. H.J. SWAN, A. ROWLINSON, J. A.G IBSON, P. BROWN, G. D. KERR, E. T. SWARBRICK & P. THORNTON 653 Correspondence. D. Y. GRAHAM 655 Correspondence. G. C. FENN VOLUME 6. NUMBER 6 . DECEMBER 1992 659 Review article: urease, gastric ammonium/ammonia, and Helicobacter pylori — the past, the present, and recommendations for future research. D. Y.G RAHAM, M. F.GO &D.J. EVANS JR 671 The effects of 5-aminosalicylic acid and acetyl-5-aminosalicylic acid on lipid peroxidation in erythrocytes and prostaglandin production by mononuclear cells. S.M. GREENFIELD, D. J. BOSWELL, N. A. PUNCHARD & R. P. H. THOMPSON 685 Effects of sumatriptan, a new selective 5HT,-like agonist, on liquid gastric emptying in man. L. A.H OUGHTON, P. FOWLER, O. N. KEENE &N. W. READ 693 Ranitidine, cimetidine, famotidine have no effect on post-prandial absorption of ethanol 0.8 g/kg taken after an evening meal. A.G. FRASER, M. HUDSON, A.M.SAWYERR, M. SMITH, S. B. ROSALKI & R. E. POUNDER 701 Absorption of polar drugs following caecal instillation in healthy volunteers. S. A. RILEY, M. KIM, F. SUTCLIFFE, M. ROWLAND &L. A. TURNBERG 707 Ranitidine: differential effects on gastric bleeding and mucosal damage induced by asprin. A. T. COLE,S. BRUNDELL, N. HUDSON, A. B. HAWTHORNE, Y.R. MAHIDA &C.J. HAWKEY 717 Acomparison of upper gastrointestinal mucosal damage by standard and delayed- release indomethacin. G. L. SWIFT, J. ARNOLD, G. T. WILLIAMS, B. D. WILLIAMS, J. RHODES & F. KHAN 727 Maintenance therapy in duodenal and gastric ulcer disease: survey of practice amongst British gastroenterologists. E. J.S. BOYD, J.G. PENSTON & K.G. WORMSLEY 739 Is oropharyngeal anaesthesia with topical lignocaine useful in upper gastrointestinal endoscopy? J.S. JAMESON, S. A. KAPADIA, R. J. POLSON, P. T.M cCARTHY & J.J. MISIEWICZ 745 The effects of flumazenil on alertness and hypoxia in elderly patients after ERCP. D.J. HAINES, D. BIBBEY & J. R. B. GREEN 751 Short report: omeprazole plus antibiotic combinations for the eradication of metronidazole-resistant Helicobacter pylori.G. D. BELL, K.U. POWELL, S. M. BURRIDGE, G. SPENCER, G. BOLTON, K. PURSER, S. BROOKS, S. PROSSER, G. HARRISON, P. W. GANT, P.H. JONES &J. E. TROWELL 759 Correspondence. J.G. PENSTON & K.G. WORMSLEY 761 Erratum 763 Index