Alexandra BW

242 Pages·2015·27.68 MB·English

Acute Kidney Injury in Critically Ill Children
Do not squeeze the kidneys!
Alexandra J.M. Zwiers
De digitale versie van dit proefschrift is te vinden op www.e-pubs.nl/?epub=a.zwiers of
door middel van onderstaande QR-code.
Printing of this thesis was fi nancially supported by:
The studies described in this thesis were supported by:
Sophia Foundation for Scientifi c Research (633)
Dutch Kidney Foundation – Kolff grant (KSBP 12.022)
ISBN: 978-94-6169-677-9
Cover design: Michelle Y.H. Zwiers
Chapter design: Michal Pelka
Layout and printing: Optima Grafi sche Communicatie (www.ogc.nl)
© 2015 A.J.M. Zwiers, Rotterdam, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in
any form by any means, without prior written permission of the copyright owner.
Acute Kidney Injury in Critically Ill Children
Do not squeeze the kidneys!
Acute nierschade in kritisch zieke kinderen
Wring de nieren niet uit!
Proefschrift
ter verkrijging van de graad van doctor aan de
Erasmus Universiteit Rotterdam
op gezag van de
rector magnifi cus
Prof.dr. H.A.P. Pols
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 17 juni 2015 om 13:30 uur
door
Alexandra Johanna Maria Zwiers
geboren te Amsterdam
PROMOTIECOMMISSIE
Promotor: Prof.dr. D. Tibboel
Overige leden: Prof.dr. J.N. van den Anker
Prof.dr. A.J. van der Heijden
Prof.dr. I.K.M. Reiss
Copromotoren: Dr. K. Cransberg
Dr. S.N. de Wildt
H
et mooiste dat het leven biedt
Zijn af en toe de dromen,
D
at alles nog beginnen moet
En ‘t beste nog moet komen.
Toon Hermans
V
oor oma Mia

CONTENTS
PART I. INTRODUCTION
Chapter 1. General introduction 11
PART II. REFERENCE VALUES
Chapter 2. Reference ranges for serum β-trace protein in neonates and children 33
younger than 1 year of age
Chapter 3. Reference intervals for renal injury biomarkers NGAL and KIM-1 in 47
young infants
PART III. ACUTE KIDNEY INJURY – ETIOLOGY & BIOMARKERS
Chapter 4. Acute kidney injury is a frequent complication in critically ill 67
neonates receiving extracorporeal membrane oxygenation: a
14-year cohort study
Chapter 5. Loop diuretics are an independent risk factor for acute kidney injury 85
in children on extracorporeal membrane oxygenation with pre-
emptive continuous hemofi ltration
Chapter 6. Urinary NGAL identifi es critically ill young children with acute kidney 101
injury following intensive care admission: a prospective cohort study
Chapter 7. Urinary NGAL predicts renal injury following extracorporeal 123
membrane oxygenation
Chapter 8. Urinary NGAL, FGF-2, and EGF concentrations in critically ill neonates 143
suff ering from acute kidney injury: a prospective observational study
PART IV. PROGRESSION TO CHRONIC KIDNEY DISEASE
Chapter 9. CKD and hypertension during long-term follow-up in children and 161
adolescents previously treated with extracorporeal membrane
oxygenation
PART V. DISCUSSION AND SUMMARY
Chapter 10. General discussion 183
Chapter 11. Summary 211
Samenvatting 217
PART VI. APPENDICES
List of abbreviations 222
About the author 225
List of publications 227
PhD Portfolio 228
Dankwoord 233