Alcohol and Nutrition. Proceedings of a Workshop on *alcohol ingestion and nutritional states

400 Pages·2011·16.01 MB·English

DOCUMENT RESUME
SP G17 846
BD 200 559
Li, Ting-Kai- Ed.: And Others
AUTHOR
Workshop on
Alcohol and Nutrition. Proceedings of a
TITLE
Indiana.
Alcohol and Nutrition (Indianapolis,
Monograph No. 2.
September 26-27, 1977).,Research
Indiana Univ., Indianapolis.
INSTITUTION
Alconolsm
National Inst. on Alcohol Abuse and
SPONS AGENCY
(DHEW/PHS), RoOtville, Md.
DHEW- ADM-79 -780
REPORT NO
PUB DATE
79
ADM-281-77-0005
CONTRACT
400p.
NOTE
MF01/PO16 Plus Postage.
EDRS -PRICE
Abuse.
*Alcoholism: Biochemistry: Biology: *Drug
DESCRIPTORS
Physical Health;
Human Body; Metabolism; *Nutrition;-,
Health
Physiology; *Research Needs: *Special
Problems
A
ABSTRACT
of alcoholism and
These 41 articles on the topic
(1) the effects of alcohol
subjects
nutrition address the following
(2) the effects of
gastrointestinal functions;
on nutrition and
the effects or alcohol on vitamin
alcohol on mineral metabolism: (3)
protein and amino acid
(4) the effects of alcohol on
metabolism;
the effects of chronic
(5) alcohol metabolism; including
metabolism:
(6) the,fetal alto of
states:
*alcohol ingestion and nutritional
the
nutrient deficiencies, an
(7)
syndrome: possible implications of
estrogen on the feminization of male
effects of dietary non-steroidal
alcoholics.
(JD)
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Reproductions supplied by EDRS are
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EDUCATIONAL RESOURCES INFORMATION
CENTER (ERIC)
This document has Wen reproduced as
reCenrea !Mori the person of organtietion
onginating it.
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Manor Charige3 have been made to imorove
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reproduction quality.
* points of ytesv or opinions stated in this OOOO
rnOnf do not noceo5OnIV rOOrOloni otriOiOiNIE
pea tion or oolrov.
EALrI=t EDUCATION. AND wELF
natal
E
Research Monograph No. 2
ALCOHOL AND NUTRITION
PrOceedings of a Workshop
September 26-27, 1977
Indianapolis, Indiana
Sponsored by
Division of Extramural Research, NIAAA
Edited by:
Ting-Kai Li
Professor of Medicine and Biochemistry
Administration Hospital
Indiana University School of Medicine and Veterans
(Indianapolis)
Steven Schenker
Professor of Medicine and Biochemistry
Vanderbilt University School of Medicine and Veterans Ldministratirr
Hospital (Nashville)
Lawrence Lumen&
Associate Professor of Medicine and Biochemistry
Hospital
Indiana University School of Medicine and Veterans Administration
(Indianapolis)
U.S. DEPARTMENT OF HEALTh, EDUCATION, AND WELFARE
Public Health Service
Alcohol, Drug Abuse, and Mental Health AdministrAtion
National Institute on Alcohol Abuse and Alcoholism
5600 Fishers Lane
Rockville, Maryland 20857
civemment Printing Orrice
For ale by the Sutwriurerpient dr 1)outirnonts,
Wazhingtun, D.C. 211401
Stork Number 017-024-410054--
This publication is the product of a research workshop on alcohol and nutri-
tion held in Indianapolis. Indiana, September 26-27, 1977. The proceedings
were compiled for the Division of Extramural Research, National Institute on
Alcohol Abuse and Alcoholism, by Drs. T7 K. Li, Lawrence Lurneng, and
Steven Schenker, under contract number ADM-2S1-77-0005 to the University
of Indiana School of Medicine. The presentations herein are those of the
listed authors and may not neces.swily reflect the opinions, official policy,
or position of the National Institute on Alcohol Abuse and Alcoholism;
Ale,Aol, Drug Abuse. and Mental Health Administration; Public Health
Seevice; or the U S. Department of Health, Edtacation, and Welfare.
The National Institute on Alcoho!. Abuse ani:. Alcoholism has obtained per-
mission from the Copyright holders to reproduce the fizmres and tables on
pp. .32, 33, :37, 40, 11, -49, 51, 52, 57=59, and 210-243. 339, and 340 and
the paper on pp. 271-279. Further reproduction of these materials is pro-
hibited without spe ific
permission of the copyright holder. All other._
material contained in the ma=nual is in the public domain and may be used
and reprinted without permission. Citation of the .g?.urce is appreciated.
The U.S. Government does not endorse or favor any specific commercial
product or commodity. Trade or proprietary names appearing in this publi-
used only because they are considered essential in the context of
cation
are.
the studies reported herein.
Catalog Card Number: 79-60C167
Library of Congeasa
DHEW Publication No. (ADM) 79-780
Printed 1979
Foreword
monographs
second in- the series of research
This volume is the
Algol Abuse and
National Institute on
recently begun by the
a number
forth current information on
Alcoholism. This series sets
alcoholism as reported
alcohol abuse and
of topics relevant to
treatment as well
research, prevention, and
through workshops in
selected subjects.
state-of-the-art reviews on
as through
based on a research
is also the second one
This _monograph
fot sup-
NIAAA. The main purposes
rkshop sponsored by
newly acquired
workshops are to disseminate
.,Thrling research
to stimu-
research opportunities,
Knowledge, to uncover new
best scientists
and to attract the
fresh ideas for study,
late
monograph'
this research
I believe that
into alcoholism research.
be achieved.
that these purposes will
series enhances the prospects
together the
accomplished by gathering
Much has already been
"Alcohol and
the research workshop on
group of scientists at
and shared with
have been presented to
Nutrition": recent findings
have yielded a criti-
forum; and discussions
other scientists in open
new studies
findings and have suggested
cal examination of these
early to determine if
of these data. It is too
as a logical extension
increased as a result
community has been
the alcoholism research
proceedings of this work-
The publication of the
of this workshop.
accomplished by
what already has been
shop will further extend
broadcasting this
of the workshop and
providing a written record
place of the workshop
immediate time and
re-cord far beyond the
itself.
Ph.D.
Albert A.. Pawlowski,
Alcoholism
Alcohol Abuse and
National Institute on
Table of Contents
Foreword
ix
L:st of Farticipants
Introduction
Kenneth R. Warren
Summary
3
Recommendations for Research Needs
19
Section L Effects of Alcohol on Nutrition aqd
Gastrointestinal. Functions
Marginal Nutritional States and Conditioned Deficiencies
23
J. Cecil Smith, Jr.
Alcohol-Nutrition Interactions.
47
Charles S. Lieber
64
Discussion of Papers by Smith and Lieber
Determinants of Absorption from the Gastrointestinal
Tract
67
John 11:.Dietsclzy
. ........
100
discussion of Paper by Dietschy.
Effect of Ethanol on the Determinants of Intestinal
Transport
...
103
Linda L. Shanbour
113
Discussion of Paper by Shanbour
CO NT ENTS
Effects of Alcohol on Mineral Metabolism
Section 11.
Recent Advances in Zinc Rio them
Bert Le Vallee
reds of Zinc on Cellular DNA and RNA Nletabolism
133
Kenneth H. Falchu
152
Discussion of Papers by Vallee and Falchuk
Effect of Ethanol on Zinc Metabolism
157
Artanda S. Prasad
163
Discussion of Paper
y Prasad
Effect of Ethanol on Magnesium Metabolism
165
James D. Beard
Pathogenesis and Effect of Phosphate Depletion in
Alcoholic
173
James P. Knoche!
189
Discussion of Paper by Knoche'
abolism
Effect of Ethan'ol on Human Mineral
191
Janet. T. McDonald
203
Discussion of Paper by McDonald
Section III. Effects of Alcohol on Vitamin Metabolism
Effect of Ethanol on Folate Absorption
Charles H. Halsted, Janice Ott, Ann M. Reisenauer,
207
and John J. Romero
220
Discussion of Paper by Halsted et al
The Effect of Ethanol on Folate Metabolism
221
Robert S. Hillman
......
227
Discussion of Paper by Hillman,
CONTENTS
VII
Isolated
IThe t 'ptake of Folate by
999
Conrad G. Wagner, Donald W. Horne, and William Briggs
Discussion of Paper by Wagner et al
ristics
on: Norm
,inal Thiamine
IntK
and affects of Ethanol
937
Anastacio M. Hoyutnpa, Jr.
.
249
Discussion of Paper by Floyumpa
!ism
Eff,.ct of Ethaitor on Vitamin Sr;
951
Lawrence Luineng
967
Discussion of Paper by Lumen'
tients
of Ci.unitine in Cachetic Cirrhotic
Deficien
271
Daniel Rudman
280
-D
)f Paper by Rudman =
Section IV. Effects of Alcohol on Protein and Amino Acid
Metabolism
Plasma Amino Acid Measurements for he Detection of
Alcoholism: Current Status
285
Sperther Shaw and Charles S. Lieber
Ethanol Consumption and Free Amilio Acids of Rat Plasma
and Liver
289
Jeng M. Hsu
Alcohol, Acetaldehyde, and Albumin Synthesis
Marcus A. RothschildVlurray Oratz, and Sidney S.
295
Schreiber
Section V. Alcohol Metabolism: including the Effects of
Chronic Alcohol Ingestion and Nutritional States
Rate-Determining Factors for Ethanol Oxidation in Vivo
and in Isolated Hepatocytes
Neal W. Cornell, Kathryn E. Crow, Mare C. Lead better
315
and Richard-L. Veech
CONTENTS
by Cornell et al
Discussion of Pa
331
Multiple Molecular Forms of Human Liver Alcohol Dehy-
drogenase: Isolation and Properties of II-ADH 4
Millar-12 F, Bosron. Ting-Kai Li. Wern.:y P. Dafeldecker.
and Bert L. Vallee
Discussion of Paper by BosrOu.er-5.1.
'347
onlineatitv of Blood Ethanol Elimination: Its Exagger-
ation After Chronic Alcohol Consumption and ICs Rela-
tionship to a Non-ADH Pathway
Mikko P Salaspuro and Charles -S. Lieber
349
Section VI. Other Effects of Alcohol on Nutrition
The Fetal Alcohol Syndrome: Possible mplic_ions of
Nutrient Deficiencies
Lucille S Hurley
367
Discussion of Paper by Hurley
360
Hypothesis Concerning the Effects of Dietary Non-
steroidal Estrogen on the Feminization of Male
Alcoholics
Roger Lester, David H. Van Thiel, Patricia K. Eagon,
A. Forrest Imhoff, and Stanley E. Fisher
383
387
Paper by _Lester et al
Discussion
389
Index
List of Participants*
-nes D. Beard. Ph.D.. .-Visociate Piofessor of Psychiatry. LUni-
versity of Tennessee Center for the Sciences; DirectorAlcOhol
ind Drug Research Center, Tennessee_ Psychiatric Hospital and
Institute, Memphis, Tenn. 38104
\Villiam F. Bosnyn;
Associate Professor of Medicine and Riot
ch-emistry, Indiana University SehotI of Medicine, Indianapolis,
Ind_ 46202
Philip A. Christiansen, M.D., Professor of Medicine and Acting
Chief of Gastroenterology, Indiana Univeriity School of Med-
icine, Indianapolis-, Ind. 46202
Neal W. Cornell, Ph.D.. Senior Scientist, Lahoratory of Metabol-
ism, 12501 Washington Ave., National Institute on Alcohol
Abuse and Alcoholism, ibocicville, Md. 20857
P. Dafeldecker, M.D., Biophysics Research 'Laboratory,
-Trier
Department of Biological Chemistry, Harvard Medical School,
Boston, Mass. 02115
Paul Desmond, M.D., Research Associate, Department of Gastro-
enterology, Vanderbilt University School of Medicine, Nash-
ville, Tenn. 37203
.John M. Dietschy, Ph.D., Professor of Medicine, University of
Texas Health Science Center, Southwestern Medical School,
Dallas, Tex. 75235
Kenneth H.
Falchuk, M.D., Biophysics Research Laboratory,
Department of Biological Chemistry, Harvard Medical School,
Bbston, Mass. 02115
Halsted, M.D., Associate Professor, Department of In-
Charles El
ternal Medicine, University of California, School of Medicine,
Davis, Calif. 95616
*Affiliations are as of the time of he workshop, September 1977.