Alcohol and Cancer: Proceedings of the Third International Conference PDF
Preview Alcohol and Cancer: Proceedings of the Third International Conference
Advances in Experimental Medicine and Biology 1032 Vasilis Vasiliou · Samir Zakhari Lopa Mishra · Helmut K. Seitz Editors Alcohol and Cancer Proceedings of the Third International Conference Advances in Experimental Medicine and Biology Volume 1032 Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical Center Hospital, Tehran, Iran More information about this series at http://www.springer.com/series/5584 Vasilis Vasiliou • Samir Zakhari • Lopa Mishra Helmut K. Seitz Editors Alcohol and Cancer Proceedings of the Third International Conference Editors Vasilis Vasiliou Samir Zakhari Department of Environmental Health Distilled Spirits Council of the US Sciences Washington, DC, USA Yale School of Public Health Yale University Helmut K. Seitz New Haven, CT, USA Salem Medical Centre University of Heidelberg Lopa Mishra Heidelberg, Baden-Württemberg, Germany Mishra Laboratory University of Texas MD Anderson Cancer Center Houston, TX, USA ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-319-98787-3 ISBN 978-3-319-98788-0 (eBook) https://doi.org/10.1007/978-3-319-98788-0 Library of Congress Control Number: 2018956727 © Springer Nature Switzerland AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface Heavy alcohol consumption is a risk factor for disease and mortality worldwide. According to epidemiological studies, chronic alcohol consumption has also been associated with a variety of cancers (oral cavity, pharynx, larynx, esophagus, liver, colorectum, breast). It appears that the risk of developing cancer increases in pro- portion to the amount of alcohol consumed. Enigmatically, alcohol intake decreases the risk of thyroid cancer, kidney and lung cancer (with evidence most strongly supporting lower risk for light and moderate drinkers) and non-Hodgkins lym- phoma, and does not appear to affect prostate cancer risk. Based upon these epide- miological data, it is evident that the capacity for alcohol to influence carcinogenesis varies between tissues or organs. This being the case, it is not unreasonable to pro- pose that the mechanisms by which alcohol promotes or represses cancer is likely to be tissue-dependent. In addition, individual risk factors including genetics also modify ethanol-mediated carcinogenesis. Given the prevalence of alcohol con- sumption in societies throughout the world and the challenges associated with effec- tive cancer treatment, a more complete understanding of the risks associated with alcohol exposure use in relation to cancer is particularly important, as is identifica- tion of the mechanisms by which alcohol influences cancer development. Recognizing this, the idea for an international meeting that focused on alcohol and cancer was born. In September 2010, the first International Congress on Alcohol and Cancer was held at the German Cancer Research Center (DKFZ) in Heidelberg, Germany. This meeting provided a venue for the presentation of research that specifically addressed alcohol and cancer. Areas of focus included recent advances in epidemiology, molecular mechanisms and biomarkers of alcohol-induced carcinogenesis, as well as anticancer therapies. After the success of the first meeting, additional International Congresses on Alcohol and Cancer have been held. The second congress took place in May 2013 at Breckenridge, Colorado, USA. Summaries of presentations from this meeting were published in Advances of Experimental Medicine and Biology 815: 1-436, 2015). In June 2015, the third congress was held in Hersonissos Crete, Greece, in June 2015. v vi Preface This book comprises papers presented during the third congress. The research described herein documents the significant progress that has been made in our understanding of the molecular mechanisms by which alcohol may affect carcino- genesis, and epidemiological studies examining how alcohol affects the risk of can- cer development. We anticipate this book will inform the reader about this important area of alcohol research and stimulate cancer investigators and clinicians to con- sider how alcohol consumption may affect their research or patient care endeavors. Finally, it is our intention to continue these congresses; the fourth will be held in Newport, Rhode Island, USA, on April 14–18, 2019. New Haven, CT, USA Vasilis Vasiliou Washington, DC, USA Samir Zakhari Washington, DC, USA Lopa Mishra Heidelberg, Germany Helmut K. Seitz Contents 1 Alcohol Consumption and Risk of Thyroid Cancer: A Population Based Case-Control Study in Connecticut . . . . . . . . . . 1 Huang Huang, Nan Zhao, Yingtai Chen, Nicole Deziel, Min Dai, Ni Li, Robert Udelsman, and Yawei Zhang 2 Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 F. Peter Guengerich and Narayan G. Avadhani 3 Glutathione and Transsulfuration in Alcohol- Associated Tissue Injury and Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Ying Chen, Ming Han, Akiko Matsumoto, Yewei Wang, David C. Thompson, and Vasilis Vasiliou 4 Fatty Liver Disease and Hepatocellular Carcinoma: The Pathologist’s View . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Dina G. Tiniakos, João Maurício, and Helen L. Reeves 5 Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 Gyongyi Szabo 6 Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues . . . . . . . . . . . . . . . . 81 Teresa Peccerella, Tatjana Arslic-Schmitt, Sebastian Mueller, Kirstin- Berit Linhart, Devanshi Seth, Helmut Bartsch, and Helmut K. Seitz 7 Role of TGF-β in Alcohol-Induced Liver Disease . . . . . . . . . . . . . . . . 93 Wilma Jogunoori and Lopa Mishra vii viii Contents 8 NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells . . . . . . . 105 Keigo Machida 9 Diet Supplementation with Soy Protein Isolate, but Not the Isoflavone Genistein, Protects Against Alcohol-Induced Tumor Progression in DEN-Treated Male Mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 K. E. Mercer, C. F. Pulliam, L. Hennings, M. A. Cleves, E. E. Jones, R. R. Drake, and M. J. J. Ronis 10 ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127 Sergey A. Krupenko and Natalia I. Krupenko 11 Developmental Morphogens & Recovery from Alcoholic Liver Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 Anna Mae Diehl 12 Suppressed Fat Mobilization Due to PNPLA3 rs738409 -Associated Liver Damage in Heavy Drinkers: The Liver Damage Feedback Hypothesis . . . . . . . . . . . . . . . . . . . . . . 153 Vanessa Rausch and Sebastian Mueller 13 Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease . . . . . 173 Kun-Che Chang and J. Mark Petrash 14 Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 Stephanie Marshall, Ying Chen, Surendra Singh, Pablo Berrios-Carcamo, Claire Heit, Nicholas Apostolopoulos, Jaya Prakash Golla, David C. Thompson, and Vasilis Vasiliou Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265 Contributors Nicholas Apostolopoulos Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA Tatjana Arslic-Schmitt Department of Medicine, Salem Medical Centre, Heidelberg, Germany Narayan D. Avadhani Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA Helmut Bartsch Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre (DKFZ), Heidelberg, Germany Pablo Berrios-Carcamo Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA Program of Molecular and Clinical Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile Kun-Che Chang Department of Ophthalmology, School of Medicine, University of Colorado, Aurora, CO, USA Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA Ying Chen Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA Yingtai Chen Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing, China M. A. Cleves Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA Arkansas Children’s Nutrition Center, Little Rock, AR, USA ix x Contributors Min Dai Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing, China Nicole Deziel Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA Anna Mae Diehl Department of Medicine, Duke University School of Medicine, Durham, NC, USA R. R. Drake Medical University of South Carolina Proteomic Center, Charleston, SC, USA Jaya Prakash Golla Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA Ming Han Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA College of Environment and Resource, Shanxi University, Taiyuan, Shanxi, China Claire Heit Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, CO, USA L. Hennings Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Huang Huang Department of Surgery, Yale School of Medicine, New Haven, CT, USA Wilma Jogunoori Center for Translational Medicine, Department of Surgery and George Washington Cancer Center, George Washington University, Washington, DC, USA Veterans Affairs Medical Center, Washington, DC, USA E. E. Jones Medical University of South Carolina Proteomic Center, Charleston, SC, USA Natalia I. Krupenko Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA UNC Nutrition Research Institute, Chapel Hill, NC, USA Sergey A. Krupenko Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA UNC Nutrition Research Institute, Chapel Hill, NC, USA Kirstin-Berit Linhart Department of Medicine, Salem Medical Centre, Heidelberg, Germany Ni Li Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing, China
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