Alcohol and Aldehyde Metabolizing Systems. Intermediary Metabolism and Neurochemistry

658 Pages·1977·36.49 MB·English

by  Ronald G. Thurman

Johnson Research Foundation Colloquia
Energy-Linked Functions of Mitochondria
Edited by Britton Chance
1963
Rapid Mixing and Sampling Techniques in Biochemistry
Edited by Britton Chance, Quentin H. Gibson, Rudolph H. Eisenhardt,
K. Karl Lonberg-Holm
1964
Control of Energy Metabolism
Edited by Britton Chance, Ronald W. Estabrook, John R. Williamson
1965
Hemes and Hemoproteins
Edited by Britton Chance, Ronald W. Estabrook, Takashi Yonetani
1966
Probes of Structure and Function of Macromolecules and Membranes
Volume I Probes and Membrane Function
Edited by Britton Chance, Chuan-pu Lee, J. Kent Blasie
1971
Probes of Structure and Function of Macromolecules and Membranes
Volume II Probes of Enzymes and Hemoproteins
Edited by Britten Chance, Takashi Yonetani, Albert S. Mildvan
1971
Biological and Biochemical Oscillators
Edited by Britton Chance, E. Kendall Pye, Amal K. Ghosh, Benno Hess
1973
Alcohol and Aldehyde Metabolizing Systems
Edited by Ronald G. Thurman, Takashi Yonetani, John R. Williamson,
Britton Chance
1974
Alcohol and Aldehyde Metabolizing Systems
Volume II Enzymology and Subcellular Organelles
Edited by Ronald G. Thurman, John R. Williamson, Henry R. Drott, Britton Chance
1977
Alcohol and Aldehyde Metabolizing Systems
Volume III Intermediary Metabolism and Neurochemistry
Edited by Ronald G. Thurman, John R. Williamson, Henry R. Drott, Britton Chance
1977
Papers contributed to Second International
Symposium on Alcohol and Aldehyde Metabolizing
Systems. Held in Philadelphia, Pennsylvania
October 15-17, 1976.
Alcohol and Aldehyde
Metabolizing Systems
Volume III
INTERMEDIARY METABOLISM
AND NEUROCHEMISTRY
Edited by
Ronald G. Thurman
Department of Pharmacology
University of North Carolina
Chapel Hill, North Carolina
John R. Williamson Henry R. Drott
Britton Chance
The Johnson Research Foundation
University of Pennsylvania
Philadelphia, Pennsylvania
Academic PreSS, Inc. New York San Francisco London 1977
A Subsidiary of Harcourt Brace Jovanovich, Publishers
ACADEMIC PRESS RAPID MANUSCRIPT REPRODUCTION
COPYRIGHT © 1977, BY ACADEMIC PRESS, INC.
ALL RIGHTS RESERVED.
NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR
TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC
OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY
INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT
PERMISSION IN WRITING FROM THE PUBLISHER.
ACADEMIC PRESS, INC.
111 Fifth Avenue, New York, New York 10003
United Kingdom Edition published by
ACADEMIC PRESS, INC. (LONDON) LTD.
24/28 Oval Road. London NW1
Main entry under title:
Alcohol and aldehyde metabolizing systems.
Vol. 1 contains papers presented at the 1st
International Symposium on Alcohol and Aldehyde
Metabolizing Systems, Stockholm, 1973; v. 2-3, papers
from the 2d, University of Pennsylvania, 1976.
Includes bibliographical references.
1. Alcohol metabolism—Congresses. 2. Alcohol
dehydrogenase—Congresses. 3. Catalase—Congresses.
1. Thurman, Ronald G., ed. II. International
Symposium on Alcohol and Aldehyde Metabolizing Systems,
1st, Stockholm, 1973. III. International Symposium
on Alcohol and Aldehyde Metabolizing Systems,
University of Pennsylvania, 1976. IV. Series: Penn-
sylvania. University. Eldridge Reeves Johnson
Foundation for Medical Physics. Colloquia.
[DNLM: 1. Alcohols—Metabolism—Congresses.
2. Aldehydes—Metabolism—Congresses. W3 IN915S
1973a / QV82 I 61 1973a]
QP801.A3 162 1973 599'.0Γ33 73-5316
ISBN 0-12-691403-6 (v. 3)
PRINTED IN THE UNITED STATES OF AMERICA
LIST OF PARTICIPANTS
Numbers in parentheses represent pages
on which authors* contributions begin.
Akerboom, T. P. M. (35), Universiteit van Amsterdam, Laboratorium voor
Biochemie, B.C.P. Jansen Instituut, Amsterdam, The Netherlands
Alexander, C. S. (529), Medical Research Labs, VA Hospital, Minneapolis,
Minnesota 55417
Anandam, N. (635), Center of Alcohol Studies, Rutgers University, New
Brunswick, New Jersey 08903
Anderson, R. A. (555), Department of Physiology, University of Illinois
Medical Center, Chicago, Illinois 60612
Anderson, Robert (295), Department of Biochemistry and Biophysics, Uni-
versity of Pennsylvania, Philadelphia, Pennsylvania 19174
Andersson, B. (355), Department of Forensic Medicine, Karolinska Insti-
tutet, Stockholm, Sweden
Baker, B. (407), Department of Biochemistry, Creighton University, Omaha,
Nebraska 68131
Bass, M. B. (649), Center of Alcohol Studies, Rutgers University, New
Brunswick, New Jersey 08903
Berger, Sosamma J. (499), Department of Pharmacology, Washington Uni-
versity School of Medicine, St. Louis, Missouri 63110
Bessesen (147), Department of Pharmacology, Institute of Medical Biology,
University of Tromsd, Tromso, Norway
Blomstrand, R. (427), Stockholms Lans Landsting, Huddinge Stukhus,
Stockholm, Sweden
Xlll
xiv LIST OF PARTICIPANTS
Bode, Christiane(261, 367), Department of Internal Medicine, University
Hospital, Mannkopffstasse, Marburg, Germany
Bode, J> C. (261, 367), Department of Internal Medicine, University Hospi-
tal Mannkopffstasse, Marburg, Germany
Brentzel, H. J. (295), Department of Biochemistry and Biophysics, Univer-
sity of Pennsylvania, Philadelphia, Pennsylvania 19174
Carlsson, C. (437), Research Department, University Hospital, Lund, Sweden
Carter, E. A. (251), G.I. Research Laboratory, Jackson Towers, Massachu-
setts General Hospital, Boston, Massachusetts 02114
Cederbaum, Arthur 1. (203, 219), Department of Pathology, Mt. Sinai
School of Medicine, New York, New York 10029
Chan, Arthur W. K. (605), Research Institute on Alcoholism, Buffalo, New
York 14203
Chance, Britton (271), Johnson Research Foundation, University of Penn-
sylvania, Philadelphia, Pennsylvania 19174
Christensen, E. (87), Laboratory of Alcohol Research, NIAAA, St. Eliza-
beths Hospital, Washington, D.C. 20032
Cook, G. A. (137), Cardiovascular Research Program, Oklahoma Medical
Research Foundation, Oklahoma City, Oklahoma 73104
Coll, K. (231), Department of Biochemistry and Biophysics, University of
Pennsylvania, Philadelphia, Pennsylvania 19174
Collins, M. A. (511), Department of Biochemistry and Biophysics, Loyola
University, Stritch School of Medicine, Maywood, Illinois 60153
Cornell, N. W. (335), Laboratory of Alcohol Research, NIAAA, St. Eliza-
beths Hospital, Washington, D.C. 20032
Craig, J. (87), Department of Pathology, University of Southern California
School of Medicine, Los Angeles, California 90033
Crow, K. E. (335), Laboratory of Alcohol Research, NIAAA, St. Elizabeths
Hospital, Washington, D.C. 20032
LIST OF PARTICIPANTS XV
Damgaard, Stig. E. (109, 185), Department of Biochemistry, University of
Copenhagen, Kdbenhavn, Denmark
Davis, E. J. (243), Department of Biochemistry, Indiana University School
of Medicine, Indianapolis, Indiana 46202
Deis, F. H. (399), Center of Alcohol Studies, Rutgers University, New
Brunswick, New Jersey 08903
DeMaster, E. G. (529), Medical Research Labs, VA Hospital, Minneapolis,
Minnesota 55417
Dodd, D. E. (417), Department of Pharmacology and Toxicology, University
of Kansas, Lawrence, Kansas 66045
Edmondson, H. (87), Department of Pathology, University of Southern Cal-
ifornia School of Medicine, Los Angeles, California 90033
Eriksson, C. J. Peter (285), Research Laboratories of the State Alcohol
Monopoly, Helsinki, Finland
Faiman, M. D. (417), Department of Pharmacology and Toxicology, Uni-
versity of Kansas, Lawrence, Kansas 66045
Ferrendelli, James A. (471), Department of Pharmacology, Washington
University School of Medicine, St. Louis, Missouri 63100
Fleischer, K. (385), Department of Pharmacology and Toxicology, University
of Braunschweig, Braunschweig, Germany
Frankel, D. (595), Department of Pharmacology, University of Toronto,
Toronto, Ontario, Canada
Freed, E. X. (635), Center of Alcohol Studies, Rutgers University, New
Brunswick, New Jersey 08903
Fried, R. (407), Department of Biochemistry, Creighton University, Omaha,
Nebraska 68131
Fuller, G. C. (177), Department of Pharmacology and Toxicology, Univer-
sity of Rhode Island, Kingston, Rhode Island 02881
Gold, B. L (575), Department of Pharmacology, Boston University School
of Medicine, Boston, Massachusetts 02118
xvi LIST OF PARTICIPANTS
Goldbeter, A. (l) Faculté des Sciences, Campus Plaine, Université Libre de
f
Bruxelles, Brussels, Belgium
Goldstein, D. B. (567), Department of Pharmacology, Stanford University
School of Medicine, Stanford, California 94305
Goodwin, D. W. (643), Department of Psychiatry, Washington Univer-
sity School of Medicine, St. Louis, Missouri 63100
Goon, D. J. W. (529), Medical Research Laboratory, VA Hospital, Minne-
apolis, Minnesota 55417
Gordon, Ellen R. (79), University Medical Clinic, Montreal General Hospi-
tal, Montreal, Quebec, Canada
Guder, W. G. (379), Institute of Clinical Chemistry, Stadt. Krankenhaus
Munchen-Schwabing, München, West Germany
Grunnet, Niels (195), Cedars-Sinai Medical Research Institute, Los Angeles,
California 90029
Hanzlik, R. (417), Department of Pharmacology and Toxicology, University
of Kansas, Lawrence, Kansas 66045
Harris, R. (87), Laboratory of Alcohol Research, NIAAA, St. Elizabeths
Hospital, Washington, D.C. 20032
Hassinen, I. (117), Department of Medical Biochemistry, University of Oulu,
Oulu, Finland
Hawkins, T. D. (537), Department of Medicine and Biochemistry, Indiana
University Medical Center, Indianapolis, Indiana 46202
Hempel, John (219), Rutgers University, New Brunswick, New Jersey 08903
Hess, B. (17), Max-Planck Institut fur Ernahrungsphysiologie, Rheinland-
damm, West Germany
Higgins, J. (87), Laboratory of Alcohol Research, St. Elizabeths Hospital,
Washington, D.C. 20032
Hiltunen, K. (117), Department of Medical Biochemistry, University of
Oulu, Oulu, Finland
LIST OF PARTICIPANTS xvii
Hurter, B. P. (575), Department of Pharmacology, Boston University School
of Medicine, Boston, Massachusetts 02118
Israel, Y. (325), Department of Pharmacology, University of Toronto,
Toronto, Ontario, Canada
Isslebacher, K. J. (251), G.I. Research Laboratory, Jackson Towers, Depart-
ment of Medicine, Massachusetts General Hospital, Boston, Massachu-
setts 02114
Jacobyansky, Andrew (583), Department of Biochemistry and Biophysics,
University of Pennsylvania, Philadelphia, Pennsylvania 19174
Jauhonen, P. (117), Department of Medical Biochemistry, University of
Oulu, Oulu, Finland
Jungermann, Kurt (65), Biochemisches-Anatomisches, Institut der Universi-
tät, Freiburg im Breisgau, Germany
Kalant, H. (595), Department of Pharmacology, University of Toronto,
Toronto, Ontario, Canada
Katz, Norbert (65), Biochemisches-Anatomisches, Institut der Universität,
Freiburg im Breisgau, Germany
Khanna, J. M. (325, 595), Department of Pharmacology, University of
Toronto, Toronto, Ontario, Canada
Kiessling, K.-H. (521). Department of Animal Nutrition, Swedish University
of Agriculture, Forestry and Veterinary Medicine, Uppsala, Sweden
Klingenberg, Martin (25), Institut for Physiologische Chemie, University of
Munich, Munich, Germany
Kobayashi, M. (485), Laboratory of Neurochemistry, Institute of Neurologi-
cal and Communicative Disorders and Stroke, Bethesda, Maryland 20014
Kondrup, J. (109), Department of Biochemistry A, University of Copen-
hagen, Copenhagen, Denmark
Lakshmanan, M. R. (125), Laboratory of Alcohol Research, NIAAA, St.
Elizabeths Hospital, Washington, D.C. 20032
xviii LIST OF PARTICIPANTS
LeBlanc, A. E. (595), Department of Pharmacology, University of Toronto,
Toronto, Ontario, Canada
Lester, D. (169, 399, 635, 649), Center of Alcohol Studies, Rutgers Univer-
sity, New Brunswick, New Jersey 08903
Li, T.-K. (537, 625), Departments of Medicine and Biochemistry, Indiana
University Medical Center, Indianapolis, Indiana 46202
Lin, G. W.-J. (169, 399, 635), Center of Alcohol Studies, Rutgers University,
New Brunswick, New Jersey 08903
Lindros, K. O. (325, 343), Research Laboratories of the State Alcohol
Monopoly, Helsinki, Finland
Lof, A. (427), Karolinska Institutet, Stockholm, Sweden
Lowry, Oliver H. (499), Department of Pharmacology, Washington Univer-
sity School of Medicine, St. Louis, Missouri 63110
Lumeng, L. (243, 537, 625), Departments of Medicine and Biochemistry,
Indiana University Medical Center, Indianapolis, Indiana 46202
Lundquist, F. (109), Department of Biochemistry A, University of Copen-
hagen, Copenhagen, Denmark
Lust, W. D. (485), Laboratory of Neurochemistry, Institute of Neurological
and Communicative Disorders and Stroke, Bethesda, Maryland 20014
McKenna, W. R. (295), Department of Biochemistry and Biophysics, Uni-
versity of Pennsylvania, Philadelphia, Pennsylvania 19174
Martini, G. A. (261), Department of Internal Medicine, University Hospital,
Marburg, Germany
Meijer, A. J. (35), Universiteit van Amsterdam, Laboratorium voor Bio-
chemie, Jansen Institute, Amsterdam, The Netherlands
Melchior, C. L. (545), Psychological Sciences, Purdue University, Lafayette,
Indiana 47906
Miller, M. (567), Department of Pharmacology, Stanford University School
of Medicine, Stanford, California 94305
LIST OF PARTICIPANTS xix
Mirin, R. (575), Department of Pharmacology, Boston University School of
Medicine, Boston, Massachusetts 02118
Mdrland, J. (147), Department of Pharmacology, Institute of Medical Biol-
ogy, University of Tromsd, Tromsd, Norway
Morris, M. A. (271), Johnson Research Foundation, University of Pennsyl-
vania, Philadelphia, Pennsylvania 19174
Murphy, E. (231), Department of Biochemistry and Biophysics, University
of Pennsylvania, Philadelphia, Pennsylvania 19174
Myers, R. D. (545), Psychological and Biological Sciences, Purdue Univer-
sity, Lafayette, Indiana 47906
Myrsten, A.-L. (391), Department of Alcohol Research, Karolinska Insti-
tutet, Stockholm, Sweden
Nagasawa, H. T. (529), Medical Research Laboratories, VA Hospital, Min-
neapolis, Minnesota 55417
Neri, A. (391), Department of Alcohol Research, Karolinska Institutet,
Stockholm, Sweden
Nilsson, B. (437), Research Department, University Hospital, Lund, Sweden
Nishiki, K. (271), Johnson Research Foundation, University of Pennsylvania,
Philadelphia, Pennsylvania 19174
Noble, E. P. (613), Director, NIAAA, Rockville, Maryland 20852
Nolan, R. J. (417), Departments of Pharmacology and Toxicology, Univer-
sity of Kansas, Lawrence, Kansas 66045
Nordström, C-H. (437), Research Department, University Hospital, Lund,
Sweden
Ontko, J. A. (137), Cardiovascular Research Program, Oklahoma Medical
Research Foundation, Oklahoma City, Oklahoma 73104
Orrego, H. (325), Department of Pharmacology, University of Toronto,
Toronto, Ontario, Canada
Orrenius, S. (355), Department of Forensic Medicine, Karolinska Institutet,
Stockholm, Sweden