ALCOHOL AND ALCOHOLISM International Journal of the Medical Council on Alcoholism Journal of the European Society for Biomedical Research on Alcoholism VOLUME CONTENTS AND AUTHOR INDEX, VOLUME 28, 1993 (2 PERGAMON ALCOHOL AND ALCOHOLISM The International Journal of the Medical Council on Alcoholism and The Journal of the European Society for Biomedical Research on Alcoholism Editorial Advisory Board P. Agarwal (Hamburg, F.R.G.) C. Guerri (Valencia, Spain) E. B. Ritson (Edinburgh, U.K.) Albano (Turin, Italy) F. Harding Burns (Newtown, Australia) D. Robinson (Adelaide, Australia) A. Anokhina (Moscow, Russia) B. D. Hore (Manchester, U.K.) S. B. Rosalki (London, U.K.) S. Bachelard (Nottingham, U.K.) M. Ingelman-Sundberg (Stockholm, E. Rubin (Philadelphia, U.S.A.) Baker (Newark, U.S.A.) Sweden) H. Seitz (Heidelberg, F.R.G.) Bassendine (Newcastle upon Tyne, U.K.)N. Kessel (Manchester, U.K.) G. K. Shaw (London, U.K.) Begleiter (New York, U.S.A.) B. E. Leonard (Galway, Eire) Dame Sheila Sherlock (London, U.K.) Bergman (Stockholm, Sweden) C. S. Lieber (New York, U.S.A.) H. Suwaki (Japan) F. E. Bloom (San Diego, U.S.A.) K. Lindros (Helsinki, Finland) B. Tabakoff (Denver, U.S.A.) J. C. Bode (Snatgart, F.R.G.) J. Littleton (London, U.K.) P. V. Taberner (Bristol, U.K.) P. F. Brain (Swansea, U.K.) M. S. Losowsky (Leeds, U.K.) R. G. Thurman (Chapel Hill, U.S.A.) D. N. Brindley (Edmonton, Canada) V. Marks (Guildford, U.K.) K. F. Tipton (Dublin, Eire) R. Deitrich (Colorado, U.S.A.) J. Morland (Oslo, Norway) H.-G. Tittmar (Ulster, U.K.) S. W. Duffy (Cambridge, U.K.) R. Nordmann (Paris, France) D. H. Van Thiel (Oklahoma City, U.S.A.) C. J. Peter Eriksson (Helsinki, Finland) J. O'Hagan (Christchurch, New Zealand) J.-P. von Wartburg (Bolligen, Switzerland) S. Gitlow (New York, U.S.A.) D. V. Parke (Guildford, U.K.) R. Williams (London, U.K.) M. Glatt (London, U.K.) M. Plant (Edinburgh, U.K.) D. H. Williamson (Oxford, U.K.) Sir Abraham Goldberg (Gilgsgow, U.K.) C. 1. Pogson (Beckenham, U.K.) M. J. World (London, U.K.) M. Grant (Geneva, Switzerland) V. Preedy (London, U.K.) A. Yoshida (Duarte, U.S.A.) Medical Council on Alcoholism 1 St Andrew’s Place Regent’s Park, London NW1 4LB, U.K. President: Chairman: Sir Douglas Black Dr E. B. Ritson Vice-Presidents: Vice-Chairmen: Patrons: M. Evans Sir John Ellis The Rt Hon. Lord Porritt B. J. Hanbury M. M. Glatt Professor H. C. Stewart Bruce McNeil Executive Director: Sir Noel Moynihan P. Abraham European Society for Biomedical Research on Alcoholism National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, 0320 Oslo 3, Norway President: Secretary: Philippe De Witte Jorg Morland Board of Directors Mario Dianzani (Italy) Magnus Ingelman-Sundberg (Sweden) John Littleton (U.K.) Dharan Agarwal (F.R.G.) Kai Lindros (Finland) Consuelo Guerri (Spain) Published 6 issues/annum in January, March, May, July, September and November Subscription Rates — Annual Institutional Subscription Rates 1994; North, Central and South America, U.S.$355, Rest of World £230. Sterling prices exclude VAT. Non-VAT registered customers in the European Community will be charged the appropriate VAT in addition to the price listed. Prices include postage and insurance, and are subject to change without notice. Specially reduced rates to individuals: Individual members of the Medical Council on Alcoholism may subscribe at the much reduced rate of £25.00 per annum. Also, any member of the European Society for Biomedical Research on Alcoholism (ESBRA) may purchase a subscription for personal use at the much reduced rate of £30.00. 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The copyright owner's consent does not extend to copying for general distribution, for promotion, for creating new works, or for resale Specific written permission must be obtained from the publisher for such copying 2}e m Fee Code for this publication is: 0735-0414/94 $6.00 + 0.00 The text paper used in this publication meets the minimum requirements of American National Standard for Information Sciences — Permanence of aper for Printed Library Materials, ANSI Z39.48-1984 Second Class Postage Paid at Newark, NJ. Postmaster send address corrections to Alcohol and Alcoholism, c/o Elsevier Science Inc., 660 White Plains Road, Tarrytown, NY 10591-5153 LIST OF CONTENTS VOLUME 28 Volume 28 Number 1 January 1993 P. M. McKeigue and G. Karmi l Invited Review: Alcohol consumption and alcohol-related prob- lems in Afro-Caribbeans and South Asians in the United Kingdom J. P. Teare, A. J. Carmichael, Detection of antibodies to acetaldehyde—albumin conjugates in F. R. Burnett and M. O. Rake alcoholic liver disease M. Yap, D. J. Mascord, Studies on the chronopharmacology of ethanol G. A. Starmer and . J. B. Whitfield G. D. Smith, L. J. Shaw, Mathematical modelling of ethanol metabolism in normal P. K. Maini, R. J. Ward, subjects and chronic alcohol misusers T. J. Peters and J. D. Murray .. L. Barry and M. F. Fleming The alcohol use disorders identification test (AUDIT) and the SMAST-13: predictive validity in a rural primary care sample J. Alvarez, D. Queipo, Patterns of alcohol consumption among the general population C. Del Rio and M. C. Garcia of Castile and Leon (Spain) ISBRA 1992 — Relevance of Nutrition in Studies of Alcohol-Related Diseases R. Watson Alcohol-nutrient interactions: a critical component of physio- logical change C. Reitz Dietary fatty acids and alcohol: effects on cellular membranes L. Earnest, E. R. Abril, Ethanol and diet-induced alterations in Kupffer cell function ’. §. Jolley and F. Martinez Salaspuro Nutrient intake and nutritional status in alcoholics Watzl and R. R. Watson Role of nutrients in alcohol-induced immunomodulation W. French Nutrition in the pathogenesis of alcoholic liver disease Bjgrneboe and G.-E. Aa. Antioxidant status and alcohol-related diseases Bjgrneboe C. D. Eskelson, O. E. Odeleye, 117 Modulation of cancer growth by vitamin E and alcohol R. R. Watson, D. L. Earnest and S. I. Mufti Book Reviews Calendar Notices Volume 28 Number 2 March 1993 A. Helander Invited Review: ESBRA Award 1993 Winner: Aldehyde dehydrogenase in blood: distribution, characteristics and poss- ible use as marker of alcohol misuse K. M. Davidson and E. B. Ritson Invited Review: The relationship between alcohol dependence and depression T. F. Meert Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of alcohol preference K. Yoshimoto and S. Komura Monitoring of ethanol levels in the rat nucleus accumbens by brain microdialysis M. Ledig, S. Simler, Alcohol exposure before pregnancy: effect on GABA levels and L. Ciesielski and P. Mandel turnover in rat offspring A. E. Henneberg, P. Boger, Antibrain antibodies in alcoholic patients F. Sahnwaldt, H. O. Dumke and H. H. Kornhuber J. G. Modell, F. B. Glaser The ethics and safety of alcohol administration in the ex- and J. M. Mountz perimental setting to individuals who have chronic, severe alcohol problems A. O. Vortmeyer 199 Letter to the Editor: Wernicke’s encephalopathy, Korsakow’s amnesic state and thiamine deficient encephalopathy 201 Book Reviews 4th CONGRESS OF THE EUROPEAN SOCIETY FOR BIOMEDICAL RESEARCH ON ALCOHOLISM — ABSTRACTS 205 Abstracts 255 Author Index 259 Calendar 260 Notices Volume 28 Number 3 May 1993 Announcement Jellinek Memorial Fund P. Anderson Invited Review: Management of alcohol problems: the role of the general practitioner M. Lejoyeux and J. Adés Invited Review: Evaluation of lithium treatment in alcoholism S. E. File, N. Andrews Anxiogenic responses of rats on withdrawal from chronic and M. Al-Farhan ethanol treatment: effects of tianeptine J. Moser, D. Bagchi, Excretion of malondialdehyde, formaldehyde, acetaldehyde and P. I. Akubue and S. J. Stohs acetone in the urine of rats following acute and chronic administration of ethanol T. Siddig, P. J. Richardson, Rates of protein synthesis in different regions of the normoten- J. Morton, B. Smith, sive and hypertrophied heart in response to acute alcohol R. A. Sherwood, J. S. Marway toxicity and V. R. Preedy . Gonzalez-Reimers, Relative and combined roles of ethanol and protein malnutrition . Conde-Martel, on muscle zinc, potassium, copper, iron, and magnesium . Santolaria-Fernandez, . Martinez-Riera, *. Rodriguez-Moreno, . Gonzalez-Hernandez and V. V. Castro-Aleman A. Diez Ruiz, J. L. Santos Perez, Tumour necrosis factor, interleukin-1 and interleukin-6 in G. Lopez Martinez, alcoholic cirrhosis J. Gonzalez Calvin, B. Gil Extremera and F. Gutierrez Gea W. S. Wassif, V. R. Preedy, The relationship between muscle fibre atrophy factor, plasma B. Summers, P. Duane, carnosinase activities and muscle RNA and protein composition N. Leigh and T. J. Peters in chronic alcoholic myopathy V. I. Kresyn, V. L. Aryaev Litonit: evaluation of clinical effectiveness and F. I. Kostev J. Price, M. Hicks A feature of alcoholic Wernicke’s encephaiopathy favourable to and G. Williams the maintenance of memory function: vomiting M. Mansson, M. Hansson, Severity of alcohol dependence; rating by patient records A.-L. Moberg and M. Berglund S. Baldwin, J. Macmillan Alcohol education courses for offenders: ten years after and J. Ball Book Reviews Calendar Notices Corrigendum Volume 28 Number 4 July 1993 J. Littleton ESBRA News D. S. Goldbloom Invited Review: Alcohol misuse and eating disorders: aspects of an association C. Brewer Invited Review: Recent developments in disulfiram treatment M. G. De Montis, Reduced [*H]SCH23390 binding and DA-sensitive adenyly! C. Gambarana, G. L. Gessa, cyclase in the limbic system of ethanol-preferring rats D. Meloni, A. Tagliamonte and E. Stefanini D. Maciejewski-Lenoir Chronic prenatal ethanol exposure does not affect the expression of selected genes in rat brain development C. M. G. Aragon, K. Spivak, Cyanamide on ethanol intake: how does it really work? B. R. Smith and Z. Amit Tr. Shinohara, I. [jiri, A comparative study of ethanol absorption in the canine S. Ameno, C. Fuke jejunum after pretreatment with cyanamide or pyrazole and K. Ameno O. Ya. Lukivskaya Utilization of ketone bodies by the rat liver, brain and heart in and V. U. Buko chronic alcohol intoxication D. Gerashchenko, Influence of pyruvate, threonine and phosphoethanolamine on B. Gorenshtein, activities of some acetaldehyde-producing enzymes T. Pyzhik and Yu. Ostrovsky J.-F. Menez, T. K. Machu, Phosphorylation of cytochrome P4502E1 (CYP2E1) by cal- B.-J. Song, M. D. Browning modulin dependent protein kinase, protein kinase C and cAMP and R. A. Deitrich dependent protein kinase E. Albano, M. Parola Evidence for the covalent binding of hydroxyethyl radicals to rat A. Comoglio and M. U. Dianzani liver microsomal proteins A. Helander, C. L6wenmo Distribution of acetaldehyde in human blood: effects of ethanol and M. Johansson and treatment with disulfiram R. Gustafson Alcohol-related expected effects and the desirability of these effects for Swedish college students measured with the alcohol expectancy questionnaire (AEQ) M. Murray and C. McMillan Problem drinking in Northern Ireland; results of a community survey using the CAGE questionnaire E. Fossey Young children and alcohol: a theory of attitude development J. MacMillan and S. Baldwin A pilot study of an alcohol education course for young women offenders: what’s good for the goose? Book Reviews Calendar Notices Volume 28 Number 5 September 1993 S. Worrall, J. de Jersey Antibodies from alcoholics, ethanol-fed rats and a rabbit and P. A. Wilce immunised with proteins modified by acetaldehyde in vitro react with liver cytosolic proteins from ethanol-fed rats J. S. Marway, L. M. Rodrigues, Effect of acute ethanol dosage on nucleotide levels in the rat J. R. Griffiths and V. R. Preedy jejunum: relationship to protein synthesis D. Pawlak, Lack of effect of acetaldehyde on the cardiovascular system in D. Morelowska-Spierzak, rats A. Azzadin, K. Wrdébel and W. Buczko T. Fukunaga, P. Sillanaukee Problems involved in the determination of endogenous acetalde- and C. J. P. Eriksson hyde in human blood R. Estruch, J. M. Nicolas, Relationship between ethanol-related diseases and nutritional E. Villegas, A. Junqué status in chronically alcoholic men and A. Urbano-Marquez J. M. Nicolas, R. Estruch, Nutritional status in chronically alcoholic men from the middle E. Antunez, E. Sacanella socioeconomic class and its relation to ethanol intake and A. Urbano-Marquez P. Jaatinen, P. Saukko Chronic ethanol exposure increases lipopigment accumulation in and A. Hervonen human heart J. L. Gonzalez-Calvin, Mineral metabolism, osteoblastic function and bone mass in . Garcia-Sanchez, V. Bellot, chronic alcoholism . Mufioz-Torres, . Raya-Alvarez and . Salvatierra-Rios . Conte, D. Barisani, Prevalence of cholelithiasis in alcoholic and genetic haemo- . Mandelli, S. Fargion, chromatotic cirrhosis . L. Fracanzani, L. Cesarini, . Bodini, S. Pistoso and P. A. Bianchi P. Saarnio Question-asking strategies in abstinent alcoholics: a study of learning potential B. M. Booth and F. C. Blow The kindling hypothesis: further evidence from a U.S. national study of alcoholic men M. Van Ruyven and J. Veenstra An inventory of the alcohol research literatyre P. E. Wainwright Letter to the Editor R. C. Reitz Response Book Reviews Calendar Notices Volume 28 Number 6 November 1993 ESBRA News J. S. Madden The definition of alcoholism S. lL. Mufti, C. D. Eskelson, Alcohol-associated generation of oxygen free radicals and tumor O. E. Odeleye and promotion V. Nachiappan F. Lamblin, D. Deuceuninck Modulation of alcohol preference by NMDA antagonists in male and P. De Witte rats E. Czarnecka and Effects of calcium antagonists on central actions of ethanol: E. Kubik-Bogucka comparative studies with nifedipine, verapamil and cinnarizine J. W. Fuseler Maternal ethanol consumption induces transient compensatory hyperplasia of developing cardiac tissue in the neonatal rat M. Alfonso, R Duran Ethanol-induced alterations in gonadotrophins secretion during and J. Marco the estrous cycle of rats C. L. Mendenhall, S. D. Rouster, The impact of age on alcohol toxicity in the rat C. J. Grossman,G . A. Roselle, S. Ghosn and P. Gartside S. Tsukamoto, T. Kanegae, Effects of seed saponins of Thea sinensis L. (Ryokucha saponin) rr. Nagoya, M. Shimamura, on alcohol absorption and metabolism rl. Kato, S. Watanabe and M. Kawaguchi Tr. Zima, L. Novak 693 Plasma xanthine oxidase level and alcohol administration and S. Stipek S. M. Berman, R A. Martinez 695 Familial alcoholism and ERPs: differences in probability sensi- and E. P. Noble tivity? B. Jonsson, I. Sernbo, 709 Hip fractures in middle-aged men: a consequence of early H. Kristensson and retirement and alcohol misuse? QO. Johnell L. Harrison, R. Carr-Hill Consumption and harm: drinking patterns of the Irish, the and M. Sutton English and the Irish in England Book Reviews Calendar Notices Volume 28 Supplement 1A 1993 PROCEEDINGS OF THE 12TH ANNUAL CONFERENCE OF THE JAPANESE SOCIETY FOR BIOMEDICAL RESEARCH ON ALCOHOLISM A. Takada Editorial Y. Ueshima, Y. Matsuda, Ethanol and acetaldehyde metabolism in cultured rat hepato- B.-Y. Wang, S. Takase cytes and A. Takada Harada and S. Zhang New strategy for detection of ALDH, mutant . Tanaka, K. Kurai, Gender-related differences in the inhibitory effect on liver . Kunitoh, K. Kondo, regeneration in alcohol-treated rats: study of polyamine meta- . Goto, S. Kawai, bolism . Warashina, T. Yamashita, . Toda, T. Monna, Nishiguchi, T. Matsui, . Kuroki and S. Otani ZAMH NK-SA.Y VWAanYg, M. Tsutsumi, Analysis of the characteristics of microheterogeneity of various Y. Ueshima, S. Takase, serum glycoproteins in chronic alcoholics Y. Matsuda and A. Takada H. Kawahara, Y. Matsuda, Effects of ethanol and acetaldehyde on the maturation of hepatic M. Tsuchishima, X.-E. Wang secretory glycoproteins and A. Takada M. Yamauchi, Y. Mizuhara Serum vitronectin receptor in alcoholic liver disease: correlation and G. Toda with fibronectin receptor and morphological features M. Tsutsumi, S. Urashima, Type IV collagen and laminin contents of livers from patients K. Nakase, S. Takase with alcoholic liver disease and A. Takada K. Akamatsu, M. Nishinobu, Effect of chronic alcohol intake on rat liver microcirculation T. Ohuchi, K. Tada assessed by the multiple indicator dilution technique and Y. Ohta K. Shiraishi, S. Matsuzaki, Impaired erythrocyte deformability and membrane fluidity in H. Ishida and H. Nakazawa alcoholic liver disease: participation in disturbed hepatic micro- circulation _ —_. Fukui, H. Kitano, Metabolic fate of endotoxin and blood tumour necrosis factor . Morimura, E. Kikuchi, levels in rats with acute and chronic alcohol loading . Matsumoto, S. Tsujita, . Kinoshita, M. Matsumoto, . Okamoto and T. Tsujii . Ishii, S. Furudera, Chronic hepatitis C in alcoholic patients: studies with various Tanaka, R. Kumashiro, HCV assay procedures . Sata, H. Abe and . Tanikawa KY“RAETSaYkZaVEsA e,R N. Takada, Relationship between alcoholic liver disease and HCV infection M. Sawada, M. Tsutsumi and A. Takada Miyakawa, C. Sato, Hepatitis C virus infection in alcoholic liver cirrhosis in Japan: its N. Izumi, J. Tazawa, contribution to the development of hepatocellular carcinoma A. Ebata, K. Hattori, H. Sakai, T. Ikeda, R. Hirata, Y. Sakai and F. Marumo H. Yokoyama, H. Ishii, Heterogeneity of hepatic acetaldehyde adducts in guinea-pigs S. Nagata, S. Moriya, after chronic ethanol administration: an immunohistochemical T. Ito, S. Kato analysis with monoclonal and polyclonal antibodies against and M. Tsuchiya acetaldehyde-modified protein epitopes T. Masumoto, M. Onji, Assay of serum interleukin 8 levels in patients with alcoholic N. Horiike and Y. Ohta hepatitis T. Tominaga, H. Suzuki, Clinical significance of measuring plasma concentrations of H. Mizuno, M. Kouno, glutamine and glutamate in alcoholic liver diseases M. Suzuki, Y. Kato, A. Sato, K. Okabe and M. Miyashita H. Suzuki, T. Tominaga, Ethanol and hydrazine sulfate induced chronic hepatic injury in H. Mizuno, M. Kouno, rats: the curative effect of administration of glucogenic amino M. Suzuki, Y. Kato, acids A. Sato, K. Okabe, T. Uchikoshi, K. Maezono, K. Mawatari and T. Maki Notices