Alcohol and abnormal protein biosynthesis; biochemical and clinical PDF
Preview Alcohol and abnormal protein biosynthesis; biochemical and clinical
AlcohaonldA bnormal ProteBiino synthesis BiochemaincdCa lli nical editbeyd MarcuAs. R othschild DepartomfeN nutc leMaerd icVientee,r Aadnmsi nriasttiHoons pital anNde wY orUkn iverSscihtooyof l Medicine NewY orNke,w Y ork MurraOyr atz DepartomfeN nutc leMaerd icVientee,r Aadnmsis ntiraHtoisopni tal anNde wY orUkn iverDseiptayr tomfeB nictoh esmtiry NewY ork, YNoerwk SidneSy.S chreiber DepartomfeN nutc lMeeadri cVientee,r Aadnmsi nriasttiHoons pital anNde wY orUkn iverSscihtooyofM l e dicine NewY orNke,w Y ork PERGAMON PRESSI NC. New York Toronto Oxford Sydney Braunschweig PERGAMON PRIENSCS. MaxweHlolu sFea,i rvPiaerwEk l,m sfNo.rYd1,.0 523 PERGAMONO F CANADA LTD. 207 QueenW'ess TtQo,ur aoyn1 1t7oO, n tario PERGAMON PRLETSDS. HeadinHgitHloalnl Olx,f ord PERGAMONP RESS( AUSTP.T)Y .L TD. RushcuBttaeySr,ys d neNy.,S .W. PERGAMONG mbH BurgpIlB,a rtazu nschweig CopyrightP©e r1g9a7mP5or,ne I snsc . LibraorfCy o ngrCeastsa loignPi unbgl icDaattiao n RothscMhairlcduA,sd olph1u29s4,- Alcohaonlda bnorpmraolt beiions ynthesis. I.A lcoholism--Coamnpdsl eiqcuaetliaoen.s 2.P rotmeeitna bodliissomr dIe.rO sr.a tz, Murray, joianutt hoIrI..S chreiSbiedrnS,e. yj, o int author. TiItIl[IeD..N LM:I .A lcohEotlh,y l- Pharmacodsy.n2a .mA ilccoholism--Complications. 3.N utridtiisoonr derbso-l-iMse4mt..Pa roteins- Biosynth5e.sP irso.t eins--MeQtUa5b5Ao 3l5i4s m. 1795] RC565.R574 61.68''6071 74-5308 ISBN0 -087-70018-5 AlRli ghRtess ervNeopd a.r otft hipsu blicmaatyib oern e produscteodr,e d in say srteoetrmr ieval transmiitnt eafdno yr mo,r bayn ym eans, elemcetcrhoanniipcch,ao lt,o copying, recording or otherwwiistehp,or uitpo err misosfPi eorng aPmorneI snsc . Prinitne dUt nhiet Setda toefAs m erica ToB obbRyo,za ,nF dr eda foarlo lft hepiarsa tnp dr esent undersattatnednaitnnaigdso, tsn ai,ns ce Preface oft heet iolodgiys,e aaaslrealesc c ompabnyis eodma el teriant ion REGARDLESS cellnuultarri ctoimobni wnietdth h e specifiocft hedeffi escetaPsse reh.a ps the mostc ontrovceormsbiianla htaisbo ene tnh aotf a lcohaosslo ciawtietdh malnutrWihtaitro onl.de ost hetsweo p ossibilnyt errsetlerastspeeldsa iynt he developomfce lnitn diicsaelaI sne ?tp haet ieinnta neo xrp erimaennitmatalhl e, dissecotfti hoeenff ectss peocfni ufitcr ioern taoslf c oohroi ltm se taboilsi tes mosdti fficudlutet o tbhoed yh'osm etoastmiecc hsamnisT.h ust,ob egitno undershtoawn da lcaonhdo/alol rt enruetdr iatffieoccnte llmueltaarlb iosimti, s necestsaodr eyv elop mseptehcoidfiscm oadnedsl ost haeta cehn timtayyb e evalusaetpeadr ately. Int hitse xwte h avceh osperno tein saystn hteeh nedspiosfi onprtr ,o tein synthiests hiuesl timfautnec toifao lncl e lTlhsem. e thofdosmr e asuring protein metaboalrieesv ma luaanttdeh dee ff ecotfas l coahnoadll teprreodt ienitnaa kree examianset dh eayff ectthh ee arlti,v sekre,l meutsaclal nedt, h ber ain. xi Acknowledgments THIS woulndo hta vbee epno ssiwbilteh otuhmteo numenetffaolro tfts h e TEXT manayu thaonrdsw ea rmeo sgtr atetfotu hle m. We alswoi stho e xpreosusrt hantkost heD epartmoefMn etd icainnde Surgertyh Veoe ft erAadnmsi nistTrhaetrwieeo rnme.a nyp eopilnev olivne d helpuisnb go tahtt he ManhattaAnd mVienrtiaestrtiaHononss piatnadal tt he VeterAadnmsi nistCreanttiOroffiancl e I.na dditwieow no,u lldi kteos inogulte threweh om ade wtohrek p ossibleA-bDrra.h aDmu ryA,c tiAnsgss tiant DirecRteosrre,ca She rviVceet,e rAadnmsi nriasttiCoenn tOrffiacl;e M r.R obert CoheCnh,i eFfi,s cDailv isMianohna,t Vteatne ranss tArdamHtioinsoipni; a tnadl MrsJ.e anE .M illSeerc,r e,t DaerpyartmoefnN tusc leMaerd icianned RadioisSoetrovpiec e. Finatlhleeyd itwoirstsho t hatnhkfe o llocwoirnpgo raftotirho enisr soufp port thiesn deavor: AbboLtatb aotrorNioerst,Ch h icaIgloli,i sAn;yo erLsatb aotrorNieewsY ,o rk, NewY or;kB eckmIanns utmrenItnsc,.M ,o untaiNneswiJ deer,s Ceoym;m ercial AlliaCnopcroer atNieownY ,o rNke,w Y orEka;s tmKaond aCko mpanRyo,c hes ter, YNoerwk H;o ffman-La-RoIcnch.eN, u tleNye,w JerseNyu;c lear AsscoiatIencs,.W, e stbuNreywY, o rMke;a Jdo hnsoEnv,a nsvIinldlieaM,en dai; RayT,u ckahNoeewY, o r;kR aythCeoomnp anWya,l th,Ma amssachussS;ee taltre RadioghriaepIsnc,. D,e sP laiInleolsii,;sEn .R .S qui&b Sbo nIsn,c P.r,i nceton, NewJ ers;ae nydS tandd BarranSdasl Ceosm panNye,w YoNrekw,Y ork. xiii Lisotf C ontributors AbelmanWna,l teHr.,, M .D. FisheVri,n cenJt.,M, .D. ProfesosfMo erd icine AssociChaiteeof f Staff HarvaMredd icSaclh ool VeterAadnmsi tnriastHioosnp ital ChieCfa,r diovaDsicvuilsairo n AssioactPer ofesosfPo hry siology BostoMna,s sachu0s21e81t ts NewY orUkn iverSscihtoyoo flM edicine AsofskRy.,M, . D. NewY orkN,e wY ork ChieLfa,b oraotfoM riyc roIbmimauln ity GarlicPk.J, . P, h.D. NatioInnaslt iotfuH teeasl th LondoSnc hoooflH ygieannedT ropical BethesMdaar,y l2a0n10d4 Medicine BaligSau,r enB,. ,P h.D. LondoEnn,g land DepartmoefNn utt riatnido nF Socoide nce GlazkAon,t honJy.,P, h.D. Massachusettosf T eIcnhsntoiltougtye ParkDea vis Caonmdp any CambriMdagses,a chu0s21e93t ts AnnA rboMri,c hi4g8a1n0 6 BeckeFrr,e deriFc.k,M, . D. HendersoGn.,,P h.D. ProfesosfPo art hology InstruicnPt hoarr macology NewY orUkn iversity Medical CVeanntdeerr Ubniilvte rSscihtoyoo flM edicine 550F irst Avenue NashviTlelnen,. NewY orkN,e wY or1k0 016 Ho,J .M, .Sc. BujaM,a ximiliLa.n,M, . D. SeniToerc hnician SeniIonrvs etigator DivisoifGo ans troenterology NatioHneaalra tn dL ung Institute ToronGteon eral Hospital NatioInnaslt iotfuH teeasl th ToronCtaon,a da BethesMdaar,y la20n10d4 · HubertC,h ristine ChangT,s unM, .Sc. LabaratdoeCr liien ica SeniRoers recahB iochemist HormonaMlaete,r nite ParkDea viasn dC ompany AcutdeeP orRto yal AnnA rboMri,c hi4g8a1n0 6 PariFsr,a nce ConnH,a rol0d,. M, .D. JeejeebhKo.yN ,. ,M .D. ChieHfe,p atRiecs earch DirecDtiovri,s oifGo ans troenterology VeterAadnmsi nistHroastpiiotna l Associate oPfrM oefdeiscsionre WesHta veCno,n nect0i61c56ut UniverosfTi otryo nto ProfeossfMo erd icine ToronCtaon,a dMaS S !Al YalUen iverSscihtoyoo flM edicine NewH aveCno,n nect0i61c50ut KavaleFrr,e derMic.,D . FalloHna,r olJd.,M, .D. AssoactPier ofeossfPo hry siology Professor-Chairman DownstMaetdei cCaeln ter DepartmoefIn ntt erMneadli cine BrooklNyenwY, o rk12 130 MedicCaoll loefgV ei rginia LeevyC,a rrolMl.,D . VirgiCnoimam onwealth UniversitPyr ofesosfMo erd icine RichmoVnidr,g i2n3i2a2 0 DirecotfHo erp atoalnodgN yu trition FerranVsi,c toJr.,P, h.DM..,D . ColloefgM ee dicainnde DenotfiN s.tJr.y SeniIonrv iegsattor Jersey NCeiwJt eyr,s 0e7y3 04 SectoifoP na thology LiebeCrh,a rleSs.,,M .D. NatioHneaalra tn dL unIgn stitute ChieSfe,c toifoLn i veDri seaasned NatioInnsatli touft esH ealth Nutrition Bethesda, 2M0a10r4y land VeterAadnmsi sntiratHioosnp ital xv xvi Lisotf Contributors BronNxe,w Y or1k40 68 ReganT,i mothJy.,M, .D. ProfeosfsM oerd icine ProfeosfsM oerd icainndDe i rector MounSti nSacih oooflM edicine DivisoifCo anr diovaDsicsuelaasre s NewY orkN,e wY ork ColloefgM ee dicinDee natnids try McFarlanAe.,S .,M .D. ofN ewJ ersaety Newark CliniRecsaela Crecnht er Newar-Nke,w J ers0e7y3 04 NorthwPiacrkHk o spital Roberts, WiCl.lMi,a. mD,. LondoHnA 31U J ChiePfa,t holSoegcyt ion England NatioHneaalra tn dL unIgn stitute MillwarDd.,J . P, h.D. NatioInnaslt iotfuH teeasl th DepartmoefNn utt rition BethesMdaar,y l2a0n10d4 LondoSnc hoooflH ygieanned Robertson-BAr.u,Mc e.,D . TropiMceadli cine AssociDaetpea,r tmoefMn etd icine LondoWnC IE7 HT Toronto GHeonsepriatla l England ToronCtaon,a dMa5 1SA 1 MorganH,o wardE,. ,M .D. RosenoeVri,c toMr.,, M .D. ProfeasnsdoC rh airman PhysicLiaahneC,yl inic DepartmoefP nhty sigoy lo DepartmoefM netd icine TheP ennsylSvtaanUtineai versity HarvaMredd icSaclh ool HershPeeyn,n syl1v07a3n3i a BostoMna,s sachu0s21e2t5t s Munro, HamNi.s,hM ,. D. RothschiMladr,c uAs. ,M .D. ProfeosfsP ohry osliogiCchaelm istry ChieNfu,c leMaerd icDienpea rtment DepartmofeN nutt rition Sacnide nFcoeo d VeterAadnmsi nistHroastpiiotna l MascshauseItntsst iotfTu etceh nology ProfeosfsM oerd icine CambriMdagses,a chu0s21e93t ts NewY orUkn iverSscihtoyoo flM edicine NobleE,r nesPt.,,P h.DM..,D . NewY orkN,e wY or1k00 10 ProfeosfsP osyrc hiaPtsyrcyh,o logy and Pharmacology RubinE,m anueMl,. D. UniverosfCi atlyi fornia ProfeasnsdoC rh airman IrviCnael,i fo9r2n6i6a4 DepartmoefPn att hology MounSti nSacih oooflM edicine OratzM,u rrayP,h .D. NewY orkN,e wY or1k00 29 AsssitaCnhti eDfe,p artmoefNn utc lear Medicine SchenkeSr.,,M .D. Veterans AdmiHnoissptirtaalt ion ProfeosfsM oerd icainnde AdjunAcsts ocPiraotfee osfsB oiro chemistrCyh ieGfa,s troenterology NewY orUkn iverCsoiltlyoe fgD ee ntistry VeterAadnmsi nistHroastpiiotna l NewY orkN,e wY or1k0 010 Nashville, Tennessee 37203 PeterTsh,e odorJer,.P ,h .D. SchreibSeird,n eSy.,,M .ScM..,D . AssociinaB tieo chemistry AttendIinntge rDneipsatr,t moefNn utc lear Coelgleo fP hysicainadSn usr geons Medicine Columbia University VeterAadnmsi naitsitHorons pital ResearBciho chemist ProfesofsC olri niMceadli cine The Mary IBmaosgseHenotest p ital NewY orUkn iverSscihtoyoo flM edicine CoopersNteowwY no,r k NewY orkN,e wY or1k00 10 RamireAzl,b ertMo.,D . SodtkUe., AsstiasnPtr ofeosfsMo erd icine DivisoifGo ans troenterology HarvaMredd icSaclh ool Toronto GHeonsepriatla l ThorndMiekmeo rLiaablo ratory ToronCtaon,a dMa5 S 1A1 BostoMna,s sachu0s21e1t8t s TewarSiu,j atPah, .D. RannelEsu,g eneD,. ,P h.D. AssainsPttr ofesDseopra,r tmofe nt InstruDcetpoarr,t moefP nhty siology PsychiaatnrdHy u maBne havior TheP ensnylvaSntiaaUt nei versity CalifoCroneliglaeo fM edicine HershPeeyn,n snyil1av0 7a33 IrviCnael,i fo9r2n6i64a LisotfC ontributxoviris WaterloJw.,C .,C MG,M .D.S,cD F,R CP ColloefgM ee dicainndDe e ntistry ProfesofsH ourm aNnu trition ofN ewJ ersey LondoSnc hoooflH ygieanned NewarNke,w J ers0e7y1 03 TropiMceadli cine ZimmonD,a vidM,. D. UniverosfLi otnyd on ChieGfa,s troentSeercotlioogny LondoWnC lE 7HT VeterAadnmsi nistHroastpiiotna l England AssoactPier ofesosfC olri niMcedailc ine ZettermRaonw,e nK,. ,M .D. NewY orUkn iverSscihtoyoo flM edicine InstruicnMt eodri cine NewY orkN,e wY or1k0 010 1 MalnutritainodnA lcoholism-OAvne rview* CarlrMlo. L eevayn Rd oweKn.Z ettaenrm DIVISIOOFNH EPATOLOGYA NDN UTRITIOCNO,L LEGOE F MEDICINAEN D DENTISTROYF N EW JERSEYN,E WARK I.I ntroduction 3 III.n terreolfaM tailuontnrsi taindoE nt hanol 3 III. InocfiN duetnrciDeee nfitc ieinnAc lyc oholism 5 IV.M echanoifsN mu triDeenfitc ieinnAc lyc oholism 7 V.I nflueonfcA el cohoolniI snmt ermeMdeitaarbyo lism 8 VI.Ma lnutrEitthiaonnao,nl dT, i ssDuaem age 11 VIIT.h erapeIumtpilci caotfMi aolnnsu triinAt licoonh olism 12 VIISIu.m mary Caonndc lusions 13 References 14 I.I NTRODUCTION Ther oloef m alnutriintt ihoepn a theongesoifsc liniacnadll a boratory abnormailnai ltcioehso hlaibsse met nh e submjueccdhte boafAt lec.o howliitchs identpiactatle rfnoso adon fda lcoihnotla ke exhibbiito cdhieffmaeinrcdea nlt morpholloegsiicos nugsg,e stinga ngdce onsnettiitcu tfiaocntaolr osf k aerye import[alnT]ch.ei tsh esiiss suppotrhtreee dm abryk daibffleyr meentta bolic effecetnsc ountienir neddi vsiudbujaelfc otlsl o(wait)no gtf aolod de privfaotri on contorfoo ble s[i2;ta] yn (db l)a rignet aokfee tsh ainnto hlpe r eseonfc neao rmal di[e3tT ]h.ip sa pperro viadnoe vse rvoifpe owss ibilnet errelaotfni uotnrsiheinpts deficaintdsm etaboolrti ocx ic eofffee tchtasni ondl e velopomfea nltt ered intermemdeitaarbyo alnidts ims sduaemg ae ailnc oho(lFiis1gm). . 11.I NTERRELATIONSO F MALNUTRITION AND ETHANOL Mediccaolm plicaotfai locnosh osluicsahms W erniec'eksn cephalopathy, beribheeradiri ts eaorsm ea,c rocaynteimchi aav e baetetnr itbuodt eefidc oift s specniufitcr iwehnitdlsee,l irtiruemm egnosuo,tr a, l cohgoalsitcar rifete ilstb et o *Aidbeyda g rafnrto tmh Nee wJ ersey DSetpaatret moefHn eta lth, Doifv iCshirIoolnnl ince ss Control. 3 4 CARROLLM .L EEVYA ND ROWENK .Z ETETRMAN METABOLIC DEPLETION or OF TOXIC EFFECTS ESSENTIAL OF NUTRIENTS ETHANOL // \\ ALTERED INTERMEDIARY METABOLISM 11 TISSUE DA MAGE Fig1. Possirbellea tioofnn suhtirpid eenfitct iodt esv elopomfe natl itnetreerdrm ye dia metaboalnidts ims sduaem agient hael coholic. duteo m etaboorlt iocxe iffce cotfes t haOnopli.n iroenmsad iinv iodnec da usative factionhr esp adtiisco radnedpr asn cre(aTtaibt1li)Ees.ff oratrsne o wu nderway bym anrye seagrrcohut pors e evaltuhaet ev asruysicnegp ttiolb iivldeiirts ye ase bya lcoihcossl;i mialpaprr oaschhoeusbl edu sefdo ro thebri ochemoirc al morpholloegsiiceo nncso untienar lecdo hoTlhisus,em t.h anol-ihnydpuoced gylcemoinalo yc cuirncs e rtaalicno hosluigcgse,sag t einnegpt riecd isp[o s4ii]tt ;i on isd uet oi nhibiotfgi lounc oenneeosgriess ulftrionmmge taboelffiecco tfs etha[n5;o]a ln di tm ayb ep revenbtyce hda ngensu tirnib eanlta nfcolel owing admirnaitsitoofnl ys[i6n,]ae n drogenic-satnear[bo1oilo]dirs,a c d rensatle r oid[s7 ]. Nutritainomdne atla baolltiecr actoimobnitsno e proadd ueccer eiancs eer ebral oxidamteitvaeb oilniu snmc omplidcealtiertdir uemm eAnns i.n creiants hee spiflnuailld a ctate-apcyirdu virantat hteaei bo s,e onfc ec hianbn lgoelo adc tiast e, charactoefr itsshttiiawscth ei cahp peafrosl lowwiitnhgd rfarwoaamll coohro l lecsosm mondleys pmiatien taiinnteaodkfl e a rqguea ntoifte itehsa[ n]8oD.le ficits oft hiammiangens,ei uomrp, h osph(aFti2eg)c . o ntridbiurteteco tt hlmeye tabolic abnoarlmirteys;ap tiorarlyk alosaissso cainahdty epdo xiinade penpdreondtulcye anerogbliycc oalnydas nia sc cumuloafts ipoinnfl aulil da ct[a9tS]ee.r isatlu dies indichaatlel ucisn,da etliiornium,n eshaiynpsde,e r lkeivastpeidnfl aulil da ctate Tabl1e Postulmaetcehda nfiostrmi ssiunej uirnty h ael coholic. ToxicoirMt eyt abolic Combined Nutrient DepletiEoffne cotfsE thanol Effects Werniceknec'hesap lopathy Delirtiruemm ens Fatltiyv er Beribheeraidr its ease Cardiomyopathy Alcohhoelpiact itis Periphneeruarlo pathy Gout Cirrhosis Macrocaynteimci a Alcohgoalsitcr itis Pancreatitis? Hypoglycemia Myopathy?
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