Advice for the Novice Investigator Advice for the Novice Investigator Examples Taken from Movement Sciences Nick Stergiou CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2020 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper International Standard Book Number-13: 978-1-138-62618-8 (Hardback) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all m aterial reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. 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Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging‑in‑Publication Data Names: Stergiou, Nicholas, author. Title: Advice for the novice investigator : examples taken from movement sciences / by Nick Stergiou. Description: Boca Raton : Taylor & Francis, a CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa, plc, 2019. | Includes bibliographical references. Identifiers: LCCN 2019017959 | ISBN 9781138626188 (hardback : acid-free paper) | ISBN 9781315229690 (e-book) Subjects: LCSH: Science—Vocational guidance. Classification: LCC Q147 .S73 2019 | DDC 502.3—dc23 LC record available at https://lccn.loc.gov/2019017959 Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com This book is dedicated to all my students, past, present, and future. Contents Preface ..............................................................................................................xiii Author .............................................................................................................xvii Chapter 1 Strong inference ..........................................................................1 1.1 Introduction ..............................................................................................1 1.2 Strong inference: The Definition ...........................................................2 1.3 Examples of strong inference .................................................................4 1.3.1 Molecular biology ......................................................................4 1.3.2 Motor control and development ..............................................4 1.3.3 Biomechanics and orthopedic surgery ...................................7 1.4 Additional thoughts on strong inference .............................................8 1.5 Strong inference – take-home messages ............................................10 References ..........................................................................................................10 Chapter 2 Getting your grant proposals funded ...................................13 2.1 Introduction ............................................................................................13 2.2 Why is grant writing important? ........................................................13 2.3 Motivation for grant writing ................................................................16 2.4 Where is the money? .............................................................................17 2.5 Tips for successful proposals for any funding agency .....................18 2.5.1 Step 1: Create your grant’s notebook ....................................19 2.5.2 Step 2: Getting you and your science ready for review .....20 2.5.3 Step 3: Look at the scientific mandates of the work you propose ..............................................................................20 2.5.4 Step 4: Making a grant proposal ...........................................21 2.5.5 Step 5: An application emerges… ..........................................22 2.5.6 Step 6: Get that grant out! .......................................................23 2.5.7 Step 7: REST, don’t quit, REST, don’t quit! ............................24 2.6 Tips for getting funding .......................................................................24 2.7 Assess your grant application ..............................................................27 2.8 Research advance: At Pitt, scientists decode the secret of getting grants – marketing helps university win $350 million a year from the NIH ..............................................................................30 vii viii Contents 2.9 Characteristics of a successful grantsperson .....................................32 References ..........................................................................................................33 Chapter 3 Writing grant proposals ...........................................................35 3.1 Introduction ............................................................................................35 3.2 The basics ................................................................................................35 3.2.1 Specific Aims and hypotheses ...............................................36 3.2.2 Hypothesis examples ..............................................................37 3.3 Writing grant proposals for the NIH ..................................................38 3.3.1 NIH basics .................................................................................38 3.3.2 Why has NIH been so successful? ........................................39 3.3.3 NIH type of awards .................................................................40 3.3.3.1 The R01 award .........................................................40 3.3.3.2 The R15 award .........................................................41 3.3.3.3 The R03 award .........................................................43 3.3.3.4 The R21 award .........................................................43 3.3.3.5 The Ruth L. Kirschstein NRSA .............................43 3.3.3.6 The Career Development Awards (Ks) ................44 3.3.4 The K25 grant – an example ...................................................47 3.3.4.1 Section 1. Introduction to revised application ......48 3.3.4.2 Section 2. The candidate ........................................52 3.3.4.3 Section 3. The research plan/strategy ..................58 3.3.5 Understanding the NIH grant application submission process .......................................................................................61 3.3.5.1 Additional hints for a successful submission process ......................................................................62 3.3.6 U nderstanding the NIH grant application review process ...63 3.3.6.1 The cover letter ........................................................64 3.3.6.2 The Study Section ...................................................65 3.3.6.3 The meeting of the Study Section – what happens behind closed doors ...............................67 3.3.7 Main review criteria ................................................................68 3.3.8 Exercise: A mini proposal review for the NIH grant titled “The Six Million Dollar Corpse,” originally devised by Dr. Thomas Buchanan from the University of Delaware and respectfully revised by Dr. Nick Stergiou from the University of Nebraska at Omaha .......................................................................................71 3.4 Top Ten common reviewer concerns ..................................................74 3.5 A ten-step plan for losers – originally devised by Dr. Thomas Buchanan from the University of Delaware and respectfully revised by Dr. Nick Stergiou from the University of Nebraska at Omaha .................................................................................................75 References ..........................................................................................................77 Contents ix Chapter 4 Writing manuscripts .................................................................79 4.1 Introduction ............................................................................................79 4.2 The scientific manuscript .....................................................................79 4.2.1 Title ............................................................................................79 4.2.2 Abstract .....................................................................................80 4.2.3 Introduction ..............................................................................80 4.2.3.1 Additional hints for the introduction ..................81 4.2.4 Methods ....................................................................................82 4.2.4.1 Additional hints for the methods .........................82 4.2.5 Results .......................................................................................83 4.2.5.1 Additional hints for the results .............................83 4.2.6 Discussion .................................................................................84 4.2.6.1 Additional hints for the discussion ......................84 4.3 General tips on effective writing .........................................................85 4.3.1 Additional general hints for effective writing ....................86 4.4 The cover letter .......................................................................................87 4.4.1 Suggesting or excluding potential reviewers ......................88 4.5 The references – citing the literature in your manuscript ...............89 4.6 What is the impact of your published manuscript? .........................89 4.7 Additional publishing tips ...................................................................91 4.7.1 When do I publish? ..................................................................91 4.7.2 How do you know if it is too soon?.......................................92 4.7.3 Surviving the review process ................................................92 4.7.4 How do you deal with rejection? ...........................................93 4.7.5 Teaching improves research writing in graduate students ................................................................................93 4.7.6 Choosing the right environment for writing .......................94 4.7.7 Writing help ..............................................................................95 References ..........................................................................................................96 Additional Readings ........................................................................................97 Chapter 5 Ethics ............................................................................................99 5.1 Introduction ............................................................................................99 5.2 Responsible conduct in research .........................................................99 5.3 Authorship ............................................................................................101 5.3.1 Why do we have problems with authorship? ....................102 5.3.2 Determining authorship credit ............................................103 5.3.3 Who should get authorship? ................................................104 5.3.4 What would the authorities say? .........................................108 5.3.5 Additional issues ....................................................................110 5.3.5.1 Honorary authorship in major journals .............110 5.3.5.2 Misrepresentation of authorship among applicants to training programs ..........................110 5.3.6 Managing authorship .............................................................110