Advances in Post-Translational Modifications of Proteins and Aging PDF
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ADVANCES IN POST-TRANSLATIONAL MODIFICATIONS OF PROTEINS AND AGING ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NA THAN BACK, State University of New York at Buffalo EPHRAIM KATCHALSKI-KATZIR, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 225 IMMUNOBIOLOGY OF PROTEINS AND PEPTIDES IV: T-CELL RECOGNITION AND ANTIGEN PRESENTATION Edited by M. Zouhair Atassi Volume 226 MOLECULAR MECHANISM OF MUSCLE CONTRACTION Edited by Haruo Sugi and Gerald H. Pollack Volume 227 OXYGEN TRANSFER FROM ATMOSPHERE TO TISSUES Edited by Norberto C. Gonzalez and M. Roger Fedde Volume 228 THE MOLECULAR IMMUNOLOGY OF COMPLEX CARBOHYDRATES Edited by Albert M. Wu and L. Garry Adams Volume 229 LIPOXINS: Biosynthesis, Chemistry, and Biological Activities Edited by Patrick Y-K Wong and Charles N. Serhan Volume 230 CELL AND MOLECULAR BIOLOGY OF THE UTERUS Edited by Wendell W. Leavitt Volume 231 ADVANCES IN POST-TRANSLATIONAL MODIFICATIONS OF PROTEINS AND AGING Edited by Vincenzo Zappia, Patrizia Galletti, Raffaele Porta, and Finn Wold Volume 232 CELLULAR Ca2+ REGULATION Edited by Douglas R. Pfeiffer, Jeanie B. McMillin-Wood, and Steve Little Volume 233 CANCER METASTASIS Edited by Giorgio Prodi, Lance A. Liotta, Pier-Luigi Lollini, Spiridione Garbisa, Sergio Gorini, Kurt Hellmann A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. ADVANCES IN POST-TRANSLATIONAL MODIFICATIONS OF PROTEINS AND AGING Edited by Vincenzo Zappia Patrizia Galletti Raffaele Porta University of Naples Naples, ltaly and Finn Wold University of Texas Health Science Center Houston, Texas SPRINGER SCIENCE+BUSINESS MEDIA, LLC Library of Congress Cataloging in Publication Data International Symposium on Post-Translational Modifications of Proteins and Aging (1st: 1987: Naples, Italy) Advances in post-translational modifications of proteins and aging 1 edited by Vincenzo Zappia ... [et al.]. (Advances in experimental medicine and biology; v. 231) p. cm. "Proceedings of the First International Symposium on Post-Translational Modifica- tions of Proteins and Aging, held May 11-15, 1987, in Naples, Italy"-T.p. verso. Includes bibliographies and index. ISBN 978-1-4684-9044-2 ISBN 978-1-4684-9042-8 (eBook) DOI 10.1007/978-1-4684-9042-8 1. Proteins-Metabolism-Congresses. 2. Aging-Physiological aspects-Con gresses. l. Zappia, Vincenzo. Il. Title. QP551.1549 1987 87-36104 599'.019245-dc19 CIP Proceedings of the First International Symposium on Post-Translational Modifications of Proteins and Aging, held May 11-15, 1987, in Naples, ltaly © 1988 Springer Science+Business Media New York Originally published by Plenum Press, New York in 1988 Softcover reprint ofthe hardcover lst edition 1988 Ali rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher PREFACE This volume contains 56 contributions presented at the 1st International Symposium on Post-Translational Modifications of Proteins and Ageing, held on the Island of Ischia (Naples, Italy) from May 11 to 15, 1987, under the auspices of the University of Naples and the Italian Society of Biochemistry. The primary aim of this interdisciplinary meeting was to promote a productive exchange among scientists from different cultural areas, and to give them the opportunity to discuss problems of common interest approached from different scientific standpoints. Although a large number of studies has led to a definition of the chemical mechanisms and of the main enzymological aspects of the several post-translational modifications of proteins, we are still far away from a complete elucidation of the functional significance of such processes. As a matter of fact, it seems reasonable that the presently available experi mental approaches and models employed to investigate the biological roles are still inadequate. The search for suitable model systems was a matter of discussion during the meeting, and will be a major challenge in the future. The most frequently employed approaches to this problem thus far have been in vitro, but several proteins reported to be excellent in vitro substrates failed to show any activity when assayed in in vivo models. The problem of substrate specificity has also been a much-discussed issue; the specificity determinants of this class of reactions have been extensively investigated in recent years, and in some instances the enzyme-substrate recognition sites have been elucidated. In many cases, primary sequence of the site of modification, as well as secondary and tertiary structures of substrate proteins, are all critical. Furthermore, substrate flexibility and site accessibility within the pertinent struc tural domains have also been proposed as relevant factors. Additional specificity determinants are the compartmentalization of many enzymes involved in the processing, as well as the dynamics of the sequence of various modifications often operative in the same protein. The first section of the book is concerned with general aspects of "Transglutaminase-Mediated Reactions" and their possible functional roles in the ageing of specific tissues. The second group of contributions deals with "Protein Methylation"; significant attention has been directed to the methylesterification of proteins at the level of altered aspartyl residues, and to the role of this reaction in the processing of "aged" proteins. The chemical aspects and the complex regulatory functions of "Protein Phosphorylation" are discussed In the third section, with special emphasis on the regulation of cell growth and transformation mediated by protein-tyrosine kinases. Additional post-translational modifications, such as ADP-ribosylation, protein glycosylation, and histone acetylation, comprise the last issue treated in this volume. We will consider our efforts worthwhile if these Proceedings inform the readers, indicating new paths and stimulating novel approaches. We v expect this book to encourage further research and understanding of the many aspects of this intriguing and complex area, and to serve as a reference source for further investigation. The Editors vi ACKNOWLEDGEMENTS The Editors wish to express their appreciation to the UniversitA di Napoli, the Societa. Italiana di Blochimica and the Consiglio Nazlonale delle Ricerche for sponsoring the Symposium. We also gratefully acknowledge the support of the following Italian institutions: Ministero della Pubblica Istruzione; Ministero degll Esteri; Assessorato alia Sanita. della Regione Campania; Assessorato al Turismo, Sport e Spettacolo della Regione Campania; Provincia di Napoli; Ente Provinciale del Turismo di Napoli; Azienda Autonoma di Soggiorno, Cura e Turismo di Ischia. The Editors also wish to extend their thanks to the authors and to PLENUM PRESS for making the prompt publication of this volume possible, and to ALM s.r.l. for taking care of the organizational aspects of the meeting. We also wish to thank Ms. Patricia Reynolds, who acted as Editorial Assistant, for the efficient performance in executing the many tasks involved in editing this volume. The cooperation of ARFACID, the newly-founded Italian Association for Pure and Applied Research on Cancer, Ageing and Degenerative Diseases, was essential to the successful outcome of this undertaking. vii CONTENTS TRANSGLUTAMINASE-RELATED REACTIONS Modulation of Cellular Transglutaminase: Protease-Induced Actl vatlon .. . . . . . . . . . . . . . . . . . . . • . . . . . . . . . • . . . . . . . . . . . . 1 S.I. Chung, S.K. Chang, E. T. Cocuzzi, J.E. Fol k, H.C. Kim, S.Y. Lee, N. Martinet, T. Nigra and H.S. Sun Primary Structure of Human Coagulation Factor XIII 15 A. Ichinose and E.W. Davie Biosynthesis of Factor XIII A and B Subunits 29 J.A. Nagy, R.L. Kradin and J. McDonagh Keratlnocyte Transglutamlnase: Regulation and Release ............ 51 R.H. Rice, R. Chakravarty, J. Chen. W. O'Callahan and A.L. Rubin Retinoid-Regulated Expression of Tissue Transglutamlnase In Normal and Leukemic Myeloid Cells ....................... 63 P.J.A. Davies, E.A. Chiocca and J.P. Stein FAB Mass Spectrometric Detection of E (y-Glutamly)Lyslne Crosslinks and (y-GlutamyI)Polyamlne Derivatives Produced by Transglutamlnase In vitro ..........•........ 73 P. Pucci, G. Marino, A. Malorni, S. Metafora, C. Esposito and R. Porta Transglutamlnase-Medlated Cross-Linking of Proteins and Cell Ageing: The Erythrocyte and Lens Models .•.............. 79 L. Lorand Post-Translational Modifications of Eye Lens Cryst8l1lns: Crossllnklng, Phosphorylation and Deamldatlon ... . . . . . . . . . . . 9!? W.W. de Jong, J.W.M. Mulders, C.E.M. Voorter, G.A.M. Berbers, W.A. Hoekman and H. Bloemendal Transglutamlnase, Donor Age, and In vitro Cellular Senescence. . . . .. 109 P.J. Blrckbichler, L.E. Anderson ar1Ciff."T. Dell'Orco Searching for the Function of Tissue Transglutamlnase: Its Possible Involvement In the Biochemical Pathway of Programmed Cell Death ......................•..•....... 119 L. Fesus and V. Thomazy ix Modulation of Cellular Reapon. . to Antigens by Uteroglobln and Tran.glut8rnlnaM • • • • • • • • • . • . • • • • • • • • • • • • • • • • . • • • . • • . .. 1 35 A.B. Mukherjee, E. Cordelia-Miele, T. Klkukawa and L. Miele Tran.glutamlnase-CAtalyzed Croaallnklng of an Immunosuppressive and Anti-Inflammatory Protein Secreted from the Rat Semi nal Vesicles......................... . . • . • . . . . . . . .. 1 53 R. Porta, C. Esposito, P. Persico, G. Peluso and S. Metafora Macrophage Transglutamln. ...: Characterization of Molecular Species and Measurement of Enzymatic Modification by Clgaretie Smoke Components •••.•.••.......•..........•. 161 W.J. Roth, S.I. Chung, L. Raju and A. Janoff Implication of Transglutamlnase In Mitogen-Induced Human Lymphocyte Blast Transformation ............•..•.....•.. 1 75 S. Metafora, G. Peluso, G. Ravagnan, A. Fusco, V. Gentile and R. Porta Post-Translational Modifications of cellular Proteins by PoIyamlnes and Polyamine-Derivatives •. . . . . . . . . . . . . . • . . . .. 185 M. Piacentini, M.P. Ceru'-Argento, M.G. Farrace and F. Autuorl PROTEIN METHYLATION Methylation, Demethylatlon, and Deamldatlon at Glutamate Residues In Membrane Chemoreceptor Proteins .............. 201 J. Stock and S. Simms Perspectives on the Biological Function and Enzymology of Protein carboxyl Methylation Reactions In Eucaryotlc and Procaryotic Cells . . • . • . • • • • . . . • . . . . . . . . . . . . . . . . . . . . . . .. 21 3 S. Clarke Mechanism of Protein Carboxyl Methyl Transfer Reactions: Structural Requirements of Methyl Accepting Substrates. . . . .. 229 P. Galletti, D. In grosso, G. Pontoni, A. Oliva and V. Zappia Modification of Isoaspartyl Peptldes and Proteins by Protein carboxyl Methyltransferase from Bovine Brain •............• 247 D.W. Aswad, B.A. Johnson, E.L. Langmack and J.M. Shirokawa Substrates of Protein carboxyl Methyltransferase: Kinetics and Mechanism of thel r Formation ••••.•.•..•...•.•......•... 261 P.J.M. van den Oetelaar and H.J. Hoenders The Carboxylmethylatlon of Membrane-Bound Proteins In the Aging Rat Brain· .•.•.•.••••.•.•..••.•.•..••.....•.•..•..... 269 O.Z. Sellinger and C.M. Kramer Enzymatic Methyl Esterification of Proteins and Ageing: the Eye Lens as a Model System for In vivo and In vitro Studies . . . •. 281 C. Manna, P. Galletti, L. del Plano, A. Oliva and--v.lappia x
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