Advances in Male Mediated Developmental Toxicity

315 Pages·2003·15.353 MB·English

by  Jack B. Bishop (auth.), Bernard Robaire, Barbara F. Hales (eds.)

ADVANCES IN
MALE MEDIATED
DEVELOPMENTAL TOXICITY
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research
RODOLFO PAOLETTI, University of Milan
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ADVANCES IN
MALE MEDIATED
DEVELOPMENTAL TOXICITY
Edited by
Bernard Robaire and Barbara E Hales
McGill University
Montreal, Quebec, Canada
Springer Science+Business Media, LLC
Library of Congress Cataloging-in-Publication Data
International Conference on Male Mediated Developmental Toxicity (2nd: 2001:
Montreal, Quebec)
Advances in male mediated developmental toxicity/edited by Bernard Robaire and
Barbara F. Hales.
p. ; cm. — (Advances in experimental medicine and biology; v. 518)
Includes bibliographical references and index.
ISBN 978-1-4613-4829-0 ISBN 978-1-4419-9190-4 (eBook)
DOI 10.1007/978-1-4419-9190-4
1. Reproductive toxicology—Congresses. 2. Spermatozoa—Congresses. 3.
Mutagenesis—Congresses. 4. Developmental toxicology—Congresses. I. Robaire, Bernard.
II. Hales, Barbara F. III. Title. IV. Series.
[DNLM: 1. Spermatogenesis—drug effects—Congresses. 2.
Abnormalities—etiology—Congresses. 3. Environmental Exposure—adverse
effects—Congresses. 4. Pregnancy Outcome—Congresses. WJ 834 16035a 2003]
RA1224.2 .156 2001
616.6'071—dc21
2002040969
ISBN 978-1-4613-4829-0
©2003 Springer Science+Business Media New York
Originally published by Kluwer Academic/Plenum Publishers in 2003
Softcover reprint of the hardcover 1st edition 2003
10 9 8 7 6 5 4 3 21
A C.I.P. record for this book is available from the Library of Congress
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PREFACE
It is nearly adecadesince the firstMale MediatedDevelopmentalToxicity conference
was held in Pittsburgh. The continuing public/scientific interest, growing amounts of
animal data,introductionofinnovativetechnologies,andincreasingquantity ofhuman
epidemiological studies all suggest that male-mediated developmental toxicity is of
majorconcern.AnumberofresearchersconcludedthataSecond InternationalConfer
enceonMale MediatedDevelopmentalToxicity wasnecessary.The ensuing volume is
particularly timely becauseitimpacts on areas of special emphasis in many countries,
withrespect tochildren's andreproductivehealth,aswell astobasic molecularmecha
nisms of environmental insult, and genetic susceptibility and predisposition.
The Programme and Local Organizing Committee, composed of Barbara Hales
(Chair,McGill University),BernardRobaire(McGill University),DanielG.Cyr(INRS/
Armand Frappier),Jacquetta M.Trasler(McGill University),Andrew F.Olshan (Uni
versity of North Carolina), Sally Perreault Damey (US EPA), Donald R. Mattison
(March of Dimes), and Jan M.Friedman (University of British Columbia),spent over
twoyears identifyingindividualswho had made keycontributions inthisfieldover the
past decade and planning various aspects of the meeting. The meeting was held in
Montreal in June 2001. A total of 132 persons, coming from five continents and
representing some 18countries, took an active rolein theproceedings.The conference
wasconsideredbyallattendees tobearousing success.Importantdiscussionswereheld
in the four break-out sessions, with a preliminary set of recommendations for action
being presented by each panel.
Wefindthroughout the volume an integrationof informationfrom laboratoryand
epidemiological studies, male reproduction, and teratology. Special emphasis on the
need for translational research emerged as a common theme of the conference and is
highlightedinseveral chapters. There isaneedtodevelop aresearchagenda inthisarea
which reflects our current understanding of biological plausibility.
Inthis volume,majorcontributions identify new developments and directions in
thefieldoverthepastdecade, aswellasthechallengesfortheyears ahead.Therangeof
topics include:parental legacies and genomics; lifestyle, occupational and therapeutic
paternalexposuresandeffects;effectsonthegamete-packagingofhumansperm;effects
onfertilizationandtheembryo; roleofDNA repair andgerm cellapoptosis;stemcells,
epigcnetics and cloning; markers of sperm quality and relationship to progeny;model
systems;implicationstocliniciansandgenetic counsellors; andimpact onreproductive
technology and legislation.
Wecould not have had this meeting without the generous support provided by a
number of governmental agencies,industry and charitable organizations. A full list of
theconference's financial sponsors is provided in the volume.Sid Parkinson provided
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excellent administrative support throughout the planning and execution phases of the
meeting aswellasvaluable supportineditingthisvolume.Weshouldalsoliketothank
Jack Bishopfortakingpicturesduring themeetingand kindlyproviding uswith them.
Theyprovideasenseofthemeetingforthosethatwerenotthereandsomememoriesfor
those that were.
BernardRobaire
Barbara F.Hales
August 2002
vi
LIST OF SPONSORS
Major Sponsor
U.S. National Institutes of Health (NIH)
National Institute of Child Health and Development (NICHD)
National Institute of Environmental Health Sciences (NIEHS)
National Cancer Institute (NCI)
Supporters
Burroughs Wellcome Foundation
Canadian Institutes for Health Research (CIHR)
Fonds de la Recherche en Sante du Quebec (FRSQ)
Hospital for Sick Children
March of Dimes
Pfizer
Schering Plough Research Institute
U.S.Environmental Protection Agency (EPA)
Donors
McGill University, Faculty of Medicine
Merck Frosst Canada
Wyeth AyerstResearch
vii
LIST OF PARTICIPANTS
Adedayo Adeeko Diana Anderson
Dept of Pharmacology & Therapeutics Dept of Biomedical Sciences
McGill University University of Bradford
3655 Prom. Sir-William-Osler Richmond Road
Montreal, QC, Canada, H3G IY6 Bradford, West Yorkshire, UK,
Tel:[phone] BD7 lDP
Fax: [phone] Tel: [phone]
Email:[email protected] Fax:[phone]
Email:[email protected]
Adriana Aguilar
Dept of Pharmacology & Therapeutics Lucy Anderson
McGill University National Cancer Institute
3655 Prom. Sir-William-Osler Bldg 538, FT Dietrich,FCRDC
Montreal, QC, Canada, H3G IY6 Frederick, MD, USA, 21702
Tel:[phone] Tel: [phone]
Fax: [phone] Fax:[phone]
Email: [email protected] Email: [email protected]
R. John Aitken Jayaprakash Aravindakshan
School of Biological & Chemical INRS-IAF
Sciences 245 Hymus Blvd
University of Newcastle Pointe Claire, QC, Canada, H9R IG6
Newcastle, NSW,Australia, 2308 Tel:[phone]
Tel:[phone] Fax:[phone]
Fax:[phone] Email:[email protected]
Email:[email protected]
Kelly Silveira e Athayde
Sarah Ali-Khan
School of Medicine
Dept of Pharmacology & Therapeutics
Sao Paulo University
McGill University
Rua Jorge Faleiros, 234
3655 Prom. Sir-William-Osler
Sao Paulo, Brasil,04342-110
Montreal, QC, Canada, H3G IY6
Tel:[phone]
Tel:[phone]
Email:[email protected]
Fax: [phone]
Email: [email protected]
ix
Jacques Auger Pointe-Claire, QC, Canada, H9R IG6
Lab.BioI. Reprod. Tel:[phone]
Pavillion Cassini Fax: [phone]
H6pital Cochin Email:johanna.barthelemy@inrs
University of Paris sante.uquebec.ca
123Bd de Port Royal
Paris, France, 75014 Marisa S. Bartolomei
Tel: [phone] University of Pennsylvania School of
Fax: [phone] Medicine
Email:[email protected] 363 CRB
paris.fr 415Curie Blvd
Philadelphia, PA,USA, 19063
Janice Bailey Tel:[phone]
Dept Sciences Animales Fax: [phone]
Universite Laval Email: [email protected]
Quebec, QC, Canada, GIK 7P4
Tel:[phone],x 3354 Tara Barton
Fax: [phone] Dept of Pharmacology & Therapeutics
email:[email protected] McGill University,
3655 Prom. Sir-William-Osler
HW Gordon Baker Montreal, QC, Canada, H3G lY6
Dept of Obstetrics and Gynaecology Tel: [phone]
Royal Women's Hospital Fax: [phone]
University of Melbourne Email: [email protected]
Melbourne, VC, Australia
Tel:[phone] Jack B. Bishop
Fax: [phone] National Institute Environmental Health
Email:[email protected] Sciences
Laboratory of Toxicology
Rodney L. Balhorn Bldg. 101, Room B339, MD B3-05
Lawrence Livermore National Research Triangle Park, NC, USA,
Laboratory 27709
PO Box 808 Tel. [phone]
Livermore, CA, USA, 94550 Fax [phone]
Tel:[phone] Email: [email protected]
Fax:[phone]
Email:[email protected] Jens Peter Bonde
Dept of Occupational Medicine
Natan Bar-Chama Aarhus University Hospital
Mt Sinai Medical Center Norrebrogade 44
One Gustave L. Levy Place, Box 1272 DK - 8000 Aarhus C, Denmark
New York,NY,USA, 10029 Email: [email protected]
Tel:[phone]
Fax:[phone] Riana Bornman
Dept of Urology
Johanna Barthelemy University of Pretoria
INRS-Sante Humaine PIB N69 Pretoria
245 Hymus Blvd Pretoria, Gauteng, South Africa, 0001
x
Tel:[phone] Tel:[phone]
Fax:[phone] Fax: [phone]
Email: [email protected] Email: [email protected]
Michael Boubelik Lucrecia Calvo
Institute of Molecular Genetics Biologia de la Reproduccion
Videnska 1083 Ecuador 1465- 2 B
Prague 4, Czech Republic, 14220 Buenos Aires, Argentina, 1425
Tel:[phone] Tel: [phone]
Fax:[phone] Fax:[phone]
Email: [email protected] Email:[email protected]
Martin Brinkworth Celine Campagna
Dept of Biomedical Sciences Dept de Sciences Animales
University of Bradford Universite Laval
Bradford, UK, BD7 lDP Quebec, QC, Canada, G1K7P4
Tel:[phone] Tel:[phone], x 6338
Fax:[phone] Fax:[phone]
Email:[email protected] Email:[email protected]
Elizabeth Brown Alastair Campbell
School of Human Biosciences Centre for Reproductive Biology
La Trobe University MRC Human Reproductive Sciences
Victoria, Australia, 3086 Unit
Tel:[phone] Edinburgh, Scotland, UK, EH3 9ET
Fax: [phone] Tel:[phone]
Email:[email protected] Fax:[phone]
Email: [email protected]
Cecil Brownie
North Carolina State University Robert Yuk Sing Cheng
3309 Horton Street National Cancer Institute
Raleigh, NC, USA, 27607 LCC,Bldg 538, Room 205E
Tel:[phone] Frederick, MD, USA, 21702
Fax: [phone] Tel: [phone]
Email:[email protected] Fax: [phone]
Email:[email protected]
Daniela Buckiova
Institute of Experimental Medicine Moon Koo Chung
Videnska 1083 KRICT
Prague 4, Czech Republic, 14220 PO Box 107,Yuseong
Tel:[phone] Daejeon, South Korea, 305-600
Fax:[phone] Tel: [phone]
Email:[email protected] Fax: [phone]
Email:[email protected]
Louis Bujan
CECOS Midi-Pyrenes Alexis Codrington
Hopital La Grave Dept of Pharmacology & Therapeutics
Toulouse, France, 31052 McGill University
xi