Advances in Chromatography: Volume 54 PDF
Preview Advances in Chromatography: Volume 54
Advances in Chromatography Advances in Chromatography Volume 54 Edited by Eli Grushka Nelu Grinberg CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2018 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper International Standard Book Number-13: 978-1-138-05595-7 (Hardback) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. 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Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Contents Contributors .............................................................................................................vii Chapter 1 Recent Progress in Fundamental Understanding and Practice of Chaotropic Chromatography: Rationalizing the Effects of Analytes’ Structure with Pharmaceutical Applications .......................1 Ana Vemić, Marko Kalinić, Jelena Čolović, Slavica Erić, and Anđelija Malenović Chapter 2 Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems .............................................................................43 Ingela Lanekoff and Julia Laskin Chapter 3 Long-Range Molecular Interactions Involved in the Retention Mechanisms of Liquid Chromatography ...........................................73 Victor David, Nelu Grinberg, and Serban C. Moldoveanu Chapter 4 Immobilized Chiral Selectors on Monolithic High-Performance Liquid Chromatography Columns ....................................................111 Ali Fouad and Ashraf Ghanem Index ......................................................................................................................169 v Contributors Jelena Čolović Marko Kalinić Department of Drug Analysis Department of Pharmaceutical Faculty of Pharmacy Chemistry University of Belgrade Faculty of Pharmacy Belgrade, Serbia University of Belgrade Belgrade, Serbia Victor David Department of Analytical Chemistry Ingela Lanekoff Faculty of Chemistry Department of Chemistry – BMC University of Bucharest Uppsala University Bucharest, Romania Uppsala, Sweden Slavica Erić Department of Pharmaceutical Julia Laskin Chemistry Physical Sciences Division Faculty of Pharmacy Pacific Northwest National Laboratory University of Belgrade Richland, Washington Belgrade, Serbia Anđelija Malenović Ali Fouad Department of Drug Analysis Chirality Program Faculty of Pharmacy Faculty of ESTEM University of Belgrade University of Canberra Belgrade, Serbia Australian Capital Territory, Australia Serban C. Moldoveanu Ashraf Ghanem R. J. Reynolds Tobacco Co. Chirality Program Winston-Salem, North Carolina Faculty of ESTEM University of Canberra Australian Capital Territory, Australia Ana Vemić Department of Quality Assurance and Nelu Grinberg Control Boehringer Ingelheim Pharmaceuticals Slaviamed Ltd. Ridgefield, Connecticut Belgrade, Serbia vii 1 Recent Progress in Fundamental Understanding and Practice of Chaotropic Chromatography Rationalizing the Effects of Analytes’ Structure with Pharmaceutical Applications Ana Vemic’, Marko Kalinic’, Jelena Cˇolovic’, Slavica Eric’, and And¯elija Malenovic’ CONTENTS 1.1 Introduction ......................................................................................................2 1.2 Retention Mechanisms in Reversed-Phase Liquid Chromatography with Chaotropic Additives ........................................................................................3 1.3 Theoretical Models of Ion-Interaction Chromatography..................................7 1.4 Factors Governing the Retention in Chaotropic Chromatography .................10 1.4.1 Effect of Chaotropic Anion Type and Concentration .........................10 1.4.2 Effect of Organic Modifier Type and Its Mobile Phase Fraction .......13 1.4.3 Effect of Column Type .......................................................................13 1.4.4 Effect of Mobile Phase pH ..................................................................15 1.4.5 Effect of Mobile Phase Ionic Strength ................................................17 1.5 Modeling the Relationship between Analytes’ Structure and Its Retention in Chaotropic Chromatography ......................................................17 1.5.1 Quantitative Structure–Retention Relationship Modeling .................17 1.5.2 QSRR Modeling in Chaotropic Chromatography ..............................18 1.6 Applications of Chaotropic Chromatography in Drug Analysis ....................24 1.7 Concluding Remarks ......................................................................................34 Acknowledgments ....................................................................................................34 References ................................................................................................................34 1
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