Advances in Breast Cancer Management PDF
Preview Advances in Breast Cancer Management
Advances in Breast Cancer Management Cancer Treatment and Research Steven T. Rosen, M.D., Series Editor Goldstein, L.J., Ozols, R. F. (eds.): Anticancer Drug Resistance. Advances in Molecular and Clinical Research. 1994. ISBN 0-7923-2836-1. Hong, W.K., Weber, R.S. (eds.): Head and Neck Cancer. Basic and Clinical Aspects. 1994. ISBN 0-7923- 3015-3. Thall, P.F. (ed): Recent Advances in Clinical Trial Design and Analysis. 1995. ISBN 0-7923-3235-0. Buckner, C. D. (ed): Technical and Biological Components of Marrow Transplantation. 1995. ISBN 0- 7923-3394-2. Winter, J.N. (ed.): Blood Stem Cell Transplantation. 1997. ISBN 0-7923-4260-7. Muggia, F.M. (ed): Concepts, Mechanisms, and New Targets for Chemotherapy. 1995. ISBN 0-7923-3525-2. Klastersky, J. (ed): Infectious Complications of Cancer. 1995. ISBN 0-7923-3598-8. Kurzrock, R., Talpaz, M. (eds): Cytokines: Interleukins and Their Receptors. 1995. ISBN 0-7923-3636-4. Sugarbaker, P. (ed): Peritoneal Carcinomatosis: Drugs and Diseases. 1995. ISBN 0-7923-3726-3. Sugarbaker, P. (ed): Peritoneal Carcinomatosis: Principles of Management. 1995. ISBN 0-7923-3727-1. Dickson, R.B., Lippman, M.E. (eds.): Mammary Tumor Cell Cycle, Differentiation and Metastasis. 1995. ISBN 0-7923-3905-3. Freireich, E.J, Kantarjian, H. (eds.): Molecular Genetics and Therapy of Leukemia. 1995. ISBN 0-7923- 3912-6. Cabanillas, F., Rodriguez, M.A. (eds.): Advances in Lymphoma Research. 1996. ISBN 0-7923-3929-0. Miller, A.B. (ed.): Advances in Cancer Screening. 1996. ISBN 0-7923-4019-1. Hait, W.N. (ed.): Drug Resistance. 1996. ISBN 0-7923-4022-1. Pienta, K.J. (ed.): Diagnosis and Treatment of Genitourinary Malignancies. 1996. ISBN 0-7923-4164-3. Arnold, A.I. (ed.): Endocrine Neoplasms. 1997. ISBN 0-7923-4354-9. Pollock, R.E. (ed.): Surgical Oncology. 1997. ISBN 0-7923-9900-5. Verweij, J., Pinedo, H.M., Suit, H.D. (eds.): Soft Tissue Sarcomas: Present Achievements and Future Prospects. 1997. ISBN 0-7923-9913-7. Walterhouse, D.O., Cohn, S. L. (eds.): Diagnostic and Therapeutic Advances in Pediatric Oncology. 1997. ISBN 0-7923-9978-1. Mittal, B.B., Purdy, lA., Ang, KK (eds.): Radiation Therapy. 1998. ISBN 0-7923-9981-1. Foon, K.A., Muss, H.B. (eds.): Biological and Hormonal Therapies of Cancer. 1998. ISBN 0-7923-9997-8. Ozols, R.F. (ed.): Gynecologic Oncology. 1998. ISBN 0-7923-8070-3. Noskin, G. A. (ed.): Management ofinfectious Complications in Cancer Patients. 1998. ISBN 0-7923- 8150-5 Bennett, C. L. (ed.): Cancer Policy. 1998. ISBN 0-7923-8203-X Benson, A. B. (ed.): Gastrointestinal Oncology. 1998. ISBN 0-7923-8205-6 Tallman, M.S. ,Gordon, L.1. (eds.): Diagnostic and Therapeutic Advances in Hematologic Malignancies. 1998. ISBN 0-7923-8206-4 von Gunten, C.F. (ed.): Palliative Care and Rehabilitation of Cancer Patients. 1999. ISBN 0-7923-8525-X Burt, RK, Brush, M.M. (eds): Advances in Allogeneic Hematopoietic Stem Cell Transplantation. 1999. ISBN 0-7923-7714-1 Angelos, P. (ed): Ethical Issues in Cancer Patient Care 2000. ISBN 0-7923-7726-5 Gradishar, W.J., Wood, W.C. (eds): Advances in Breast Cancer Management. 2000. ISBN 0-7923-7890-3 ADVANCES IN BREAST CANCER MANAGEMENT edited by William J. Gradishar, M.D. Associate Professor of Medicine Director, Breast Medical Oncology Division of Hematology/Oncology Robert H. Lurie Comprehensive Cancer Center Northwestern University Medical School, USA and William C. Wood, M.D. Joseph Brown Whitehead Professor and Chairman Department of Surgery Emory University School of Medicine, USA ..... " SPRINGER SCIENCE+BUSINESS MEDIA, LLC ISBN 978-1-4757-3149-1 ISBN 978-1-4757-3147-7 (eBook) DOI 10.1007/978-1-4757-3147-7 Copyright ~ 2000 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2000 Softcover reprint ofthe hardcover Ist edition 2000 AU rights reserved. No part of this publication may be reproduced, stared in a retrieval system or transmitted in any form or by any means, mechanical, photo copying, recording, or otherwise, without the prior written permission of the publisher, Springer Science+Business Media, LLC Printed on acid-free paper. Table of Contents List of Author's Titles/Address ........................................................................ vii Preface ............................................................................................................... xi 1. Managing Menopausal Problems ................................................................. 1 MELODY A. COBLEIGH 2. Sentinel Lymphadenectomy in Node Negative Breast Cancer ................... 25 PIDLIP 1. HAIGH and ARMANDO E. GIULIANO 3. Postmastectomy Radiotherapy ................................................................... 39 ABRAM RECHT 4. The Molecular and Cellular Biology of HER2/neu Gene Amplification/ Overexpression and the Clinical Development of Herceptin (Trastuzumab Therapy for Breast Cancer .......................................................................... 57 MARK D. PEGRAM, GOTTFRIED KONECNY, and DENNIS SLAMON 5. High-Dose Chemotherapy for Breast Cancer ............................................. 77 Y AGO NIETO and ELIZABETH 1. SHPALL 6. High Dose Therapy with Stem Cell Support for Breast Cancer: The Jury Is Still Out ................................................................................. 115 MICHAEL CRUMP and KATHLEEN PRITCHARD 7. Preoperative Chemotherapy for Operable Breast Cancer ......................... 137 ELEFTHERIOS P. MAMOUNAS and BERNARD FISHER 8. Overview of Randomized Trials of Systemic Adjuvant Therapy ............ 157 PETER M. RA VDIN 9. Chemoprevention of Breast Cancer. ......................................................... 183 RUTH M. O'REGAN Index ............................................................................................................... 209 List of Author' s Titles/Addresses Melody A. Cobleigh, M.D. Professor of Medicine Director, Comprehensive Breast Center Rush-Presbyterian-St. Luke's Medical Center 1725 West Harrison Street Suite 821 Chicago, IL 60612 Michael Crump, M.D. Associate Professor of Medicine Toronto-Sunnybrook Regional Cancer Center 2075 Bayview Avenue Toronto, Ontario M4N 3M5 Canada Bernard Fisher, M.D. Distinguish Service Professor University of Pittsburgh Allegheny University of the Health Sciences Four Allegheny Center Suite 602 Pittsburgh, PA 15212-5234 William J. Gradishar, M.D. Associate Professor of Medicine Director, Breast Medical Oncology Northwestern University Medical School Division of Hematology/Oncology Robert H. Lurie Comprehensive Cancer Center 676 North St. Clair Street Suite 850 Chicago, IL 60611-2927 Armando E. Giuliano, M.D. Chief of Surgical Oncology John Wayne Cancer Institute at St. John's Health Center Clinical Professor of Surgery UCLA School of Medicine John Wayne Cancer Institute 2200 Santa Monica Boulevard Santa Monica, CA 90404 Philip J. Haigh, M.D., F.R.C.S.(C.) Clinical Fellow John Wayne Cancer Institute Surgical Oncology 2200 Santa Monica Boulevard Santa Monica, CA 90404 Gottfried Konecny, M.D. Post-Graduate Research Fellow Division of Hematology/Oncology Department of Medicine University of California, Los Angeles 11-934 Factor Building 10833 LeConte A venue Los Angeles, CA 90095-1678 Eleftherios P. Mamounas, M.D. Clinical Assistant Professor in Surgery Case Western Reserve University Mt. Sinai Center for Breast Health 26900 Cedar Road Suite 310 Beachwood,OH 44122 Yago Nieto, M.D. Instructor University of Colorado Health Sciences Center Bone Marrow Transplant Program 4200 East 9th Avenue Denver, CO 80262 Ruth M. O'Regan, M.D. Instructor Northwestern University Medical School Division of Hematology/Oncology Robert H. Lurie Comprehensive Cancer Center 676 North St. Clair Street Suite 850 Chicago,IL 60611-2927 Mark D. Pegram, M.D. Adjunct Assistant Professor Division of Hematology/Oncology Department of Medicine University of California, Los Angeles 11-934 Factor Building 10833 LeConte A venue Los Angeles, CA 90095-1678 Kathleen Pritchard, M.D. Professor of Medicine Toronto-Sunnybrook Regional Cancer Center 2075 Bayview Avenue Toronto, Ontario M4N 3M5 Canada Peter M. Ravdin, M.D. Associate Professor of Medicine University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive, Room 5 San Antonio, TX 78284-6200 Abram Recht, M.D. Associate Professor of Medicine Harvard Medical School and Beth Israel Deaconess Medical Center Department of Radiation Oncology 330 Brookline Avenue Boston, MA 02215-5491 Elizabeth J. Shpall, M.D. Professor of Medicine University of Colorado Health Sciences Center Bone Marrow Transplant Program 4200 East 9th Avenue Denver, CO 80262 Dennis J. Siamon, M.D., Ph.D. Professor and Chief Division of Hematology/Oncology Department of Medicine University of California, Los Angeles 11-934 Factor Building 10833 LeConte A venue Los Angeles, CA 90095-1678 William C. Wood, M.D. Joseph Brown Whitehead Professor and Chairman Clinical Director, Cancer Center Emory University School of Medicine Department of Surgery 1364 Clifton Road, N.E. Suite B206 Atlanta, GA 30322-1104
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