Advanced bioactive inorganic materials for bone regeneration and drug delivery

237 Pages·2013·13.546 MB·English

by  Chengtie Wu, Jiang Chang, Yin Xiao

Biomedical Engineering
W
Advanced Bioactive Inorganic
u
g
Bioceramics play an important role in repairing and regenerating defective or C
h
damaged bone. Annually, more than 500,000 bone graft procedures are performed a
n
g
in the United States and approximately 2.2 million are conducted worldwide. Xg Materials for Bone
Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug ia
o
Delivery reviews the latest advances in the field of bioceramics. The book
summarizes innovative concepts, bioceramic design, and methods for material A
d Regeneration and Drug Delivery
synthesis and drug delivery.
v
a
n
Offering guidance for biomedical engineering researchers and material scientists, ce
d
the book explores:

B
• Novel mesoporous bioactive glasses and silicate-based ceramics for io
a
bone regeneration and drug delivery c
t
i
v
• Bioactive silicate ceramics, including their mechanical properties, e

interaction with bone-forming cells, and “in vivo” osteogenesis I
n
and angiogenesis o
r
g
• Silica nanospheres with a core-shell structure and their specific a
n
properties for controllable drug delivery ic

M
• The 3D-printing technique to prepare advanced bioceramic scaffolds
a
for bone tissue engineering applications—including the preparation, te
r
mechanical strength, and biological properties of 3D-printed porous i
a
l
scaffolds of calcium phosphate cement and silicate bioceramics s

f
o
• Biomimetic preparation and controllable crystal growth and r

biomineralization of bioceramics B
o
n
• Inorganic and organic composite materials and their unique biological, e

electrical, and mechanical properties that enable the design of excellent R
e
bone regeneration and gene delivery systems g
e
n
e
A comprehensive survey of the research progress of bioceramics and their ra
t
applications in bone repair and regeneration, this volume is designed to enhance io
n
study and career development for those in this field and to facilitate further research

a
and opportunities for new solutions. n
d

D
r
u Edited by
g

D
e
K15196 l Chengtie Wu Jiang Chang Yin Xiao
i
6000 Broken Sound Parkway, NW v g g
Suite 300, Boca Raton, FL 33487 ISBN: 978-1-4665-5199-2 e
r
711 Third Avenue 90000 y
New York, NY 10017
an informa business
2 Park Square, Milton Park
www.taylorandfrancisgroup.com Abingdon, Oxon OX14 4RN, UK
9 781466 551992
w w w. c r c p r e s s . c o m
K15196 cvr mech.indd 1 2/7/13 10:41 AM

Advanced Bioactive Inorganic
Materials for Bone
Regeneration and Drug Delivery

Advanced Bioactive Inorganic
Materials for Bone
Regeneration and Drug Delivery
Edited by
Chengtie Wu Jiang Chang Yin Xiao
g g
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2013 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20130111
International Standard Book Number-13: 978-1-4665-5200-5 (eBook - PDF)
This book contains information obtained from authentic and highly regarded sources. Reasonable efforts
have been made to publish reliable data and information, but the author and publisher cannot assume
responsibility for the validity of all materials or the consequences of their use. The authors and publishers
have attempted to trace the copyright holders of all material reproduced in this publication and apologize to
copyright holders if permission to publish in this form has not been obtained. If any copyright material has
not been acknowledged please write and let us know so we may rectify in any future reprint.
Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmit-
ted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented,
including photocopying, microfilming, and recording, or in any information storage or retrieval system,
without written permission from the publishers.
For permission to photocopy or use material electronically from this work, please access www.copyright.
com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood
Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and
registration for a variety of users. For organizations that have been granted a photocopy license by the CCC,
a separate system of payment has been arranged.
Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used
only for identification and explanation without intent to infringe.
Visit the Taylor & Francis Web site at
http://www.taylorandfrancis.com
and the CRC Press Web site at
http://www.crcpress.com
Contents
Preface ....................................................................................................................vii
Acknowledgments .................................................................................................ix
Editors ......................................................................................................................xi
Contributors .........................................................................................................xiii
1. Mesoporous Bioactive Glasses for Drug Delivery and Bone
Tissue Regeneration .......................................................................................1
Chengtie Wu, Jiang Chang, and Yin Xiao
2. Silicate-Based Bioactive Ceramics for Bone Regeneration
Application .....................................................................................................25
Chengtie Wu, Yin Xiao, and Jiang Chang
3. Functional Mesoporous Silica Nanoparticles with a Core-Shell
Structure for Controllable Drug Delivery ...............................................47
Yufang Zhu
4. 3D Plotting of Bioceramic Scaffolds under Physiological
Conditions for Bone Tissue Engineering ................................................83
Yongxiang Luo, Anja Lode, Chengtie Wu, and Michael Gelinsky
5. Biomimetic Preparation and Biomineralization of Bioceramics ......117
Zhongru Gou, Ahmed Ballo, and Wei Xia
6. Preparation and Mechanism of Novel Bioceramics with
Controllable Morphology and Crystal Growth ...................................147
Kaili Lin and Jiang Chang
7. Bioactive Inorganic and Organic Composite Materials for Bone
Regeneration and Gene Delivery ............................................................177
Yufeng Zhang and Chengtie Wu
© 2008 Taylor & Francis Group, LLC v

Preface
Bioceramics play an important role in repairing and regenerating bone
defects. Annually, more than 500,000 bone graft procedures are performed
in the United States and approximately 2.2 million are conducted worldwide.
The estimated cost of these procedures approaches $2.5 billion per year.
Around 60% of the bone graft substitutes available on the market involve
bioceramics. It is reported that bioceramics in the world market increase by
9% per year. For this reason, the research of bioceramics has been one of the
most active areas during the past several years. Considering the significant
importance of bioceramics, our goal was to compile this book to review the
latest research advances in the field of bioceramics. The text also summa-
rizes our work during the past 10 years in an effort to share innovative con-
cepts, design of bioceramics, and methods for material synthesis and drug
delivery. We anticipate that this text will provide some useful information
and guidance in the bioceramics field for biomedical engineering research-
ers and material scientists.
Information on novel mesoporous bioactive glasses and silicate-based
ceramics for bone regeneration and drug delivery are presented. Mesoporous
bioactive glasses have shown multifunctional characteristics of bone regen-
eration and drug delivery due to their special mesopore structures, whereas
silicate-based bioceramics, as typical third-generation biomaterials, possess
significant osteostimulation properties. Silica nanospheres with a core-shell
structure and specific properties for controllable drug delivery have been
carefully reviewed—a variety of advanced synthetic strategies have been
developed to construct functional mesoporous silica nanoparticles with a
core-shell structure, including hollow, magnetic, or luminescent, and other
multifunctional core-shell mesoporous silica nanoparticles. In addition,
multifunctional drug delivery systems based on these nanoparticles have
been designed and optimized to deliver the drugs into the targeted organs
or cells, with a controllable release fashioned by virtue of various internal
and external triggers. The novel 3D-printing technique to prepare advanced
bioceramic scaffolds for bone tissue engineering applications has been
highlighted, including the preparation, mechanical strength, and biological
properties of 3D-printed porous scaffolds of calcium phosphate cement and
silicate bioceramics. Three-dimensional printing techniques offer improved
large-pore structure and mechanical strength. In addition, biomimetic prep-
aration and controllable crystal growth as well as biomineralization of bio-
ceramics are summarized, showing the latest research progress in this area.
Finally, inorganic and organic composite materials are reviewed for bone
regeneration and gene delivery. Bioactive inorganic and organic composite
© 2008 Taylor & Francis Group, LLC vii
viii Preface
materials offer unique biological, electrical, and mechanical properties for
designing excellent bone regeneration or gene delivery systems.
It is our sincere hope that this book will update the reader as to the research
progress of bioceramics and their applications in bone repair and regenera-
tion. It will be the best reward to all the contributors of this book if their
efforts herein in some way help readers in any part of their study, research,
and career development.
© 2008 Taylor & Francis Group, LLC