Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies PDF
Preview Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies
Recent Results 67 in Cancer Research Fortschritte der Krebsforschung Progres dans Ies recherches sur Ie cancer Edited by V. G. Allfrey, New York· M. Allgower, Basel I. Berenblum, Rehovoth . F. Bergel, Jersey J. Bernard, Paris . W. Bernhard, Villejuif N. N. Blokhin, Moskva . H. E. Bock, Tubingen W. Braun, New Brunswick . P. Bucalossi, Milano A. V. Chaklin, Moskva· M. Chorazy, Gliwice G. J. Cunningham, Richmond· G. Della Porta, Milano P. Denoix, Villejuif . R. Dulbecco, La Jolla H. Eagle, New York· R. Eker, Oslo R. A. Good, New York . P. Grabar, Paris R. J. C. Harris, Salisbury· E. Hecker, Heidelberg R. Herbeuval, Vandoeuvre . J. Higginson, Lyon W. C. Hueper, Fort Myers· H. [sliker, Lausanne J. Kieler, Kobenhavn . W. H. Kirsten, Chicago G. Klein, Stockholm . H. Koprowski, Philadelphia L. G. Koss, New York· G. Martz, Zurich G. Mathe, Villejuif . O. Muhlbock, Amsterdam W. Nakahara, Tokyo . L. J. Old, New York V. R. Potter, Madison . A. B. Sabin, Charleston, S.c. L. Sachs, Rehovoth . E. A. Saxen, Helsinki C. G. Schmidt, Essen· S. Spiegelman, New York W. Szybalski, Madison· H. Tagnon, Bruxelles R. M. Taylor, Toronto . A. Tissieres, Geneve E. Uehlinger, Zurich . R. W. Wissler, Chicago Editor in Chief: P. Rentchnick, Geneve Chemotherapy ! Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I Markers and General Problems of Cancer Adjuvant Therapies Edited by G. Bonadonna G. Mathe S. E. Salmon With 64 Figures and 40 Tables Springer-Verlag Berlin Heidelberg New York 1979 1978 Annual Plenary Meeting of the European Organization for Research on Treatment of Cancer, Paris, June 1978 Professor Gianni Bonadonna Istituto Nazionale dei Tumori, Via Venezian 1 1-20133 Milano Professor Georges Mathe Institut de Cancerologie et d'Immunogenetique Hopital Paul-Brousse, 14-16, Avenue Paul-Vaillant-Couturier F-94800 Villejuif Professor Sydney E. Salmon University of Arizona Cancer Center 1501 North Campbell Ave. Tucson, Arizona 85724/USA Sponsored by Swiss League against Cancer ISBN-13:978-3-642-81322-1 e-ISBN-13 :978-3-642-81320-7 DOl: 10.1007/978-3-642-81320-7 Library of Congress Cataloging in Publication Data. European Organization for Research on Treatment of Cancer. Adjuvant therapies and markers of post-surgical minimal residual disease I & II. (Recent results in cancer research; 67-68) "1978 annual plenary meeting of the European Organization for Research on Treatment of Cancer, Paris, June 1978." "Sponsored by the Swiss League against Cancer." Bibliography: p. Includes index. 1. Cancer-Congresses. 2. Cancer-Surgery-Congresses. 3. Tumor proteins-Congresses. 4. Therapeutics-Congresses. l. Bonadonna, G., 1934 - II. Mathe, Georges, 1922 - III. Salmon, Sydney E. - IV. Schweizerische Nationalliga fUr Krebsbekiimpfung und Krebsforschung. - V. Title. VI. Series. RC26l.R35 no.67-68 [RC270.8) 616.9'.94'008s 79-9998 [616.9'94'06) This work is subject to copyright. All rights are reserved. whether the whole or part of the material is concerned. specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are for other than private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. © Springer-Verlag Berlin . Heidelberg 1979 Softcover reprint of the hardcover 1st edition 1979 The use of registered names, trademarks, etc. in the publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. 2125/3140-543210 Contents P. Denoix and G. Mathe: Introduction ........................................... . I. Incidence, Kinetics and Markers of Post-Surgical Minimal Residual Disease S. E. Salmon: Kinetics of Minimal Residual Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 x. Y. Bertagna, W. E. Nicholson, K. Tanaka, Ch. D. Mount, G. D. Sorenson, O. S. Pettengill, and D. N. Orth: Ectopic Production of ACTH, Lipotropin, and ,l3-Endorphin by Human Cancer Cells. Structurally Related Tumor Markers...... . ... ... .. ... .... .... ... .... 16 R. E. Myers, D. J. A. Sutherland, J. W. Meakin, D. G. Malkin, J. A. Kellen, and A. Malkin: Prognostic Value of Postoperative Blood Levels ofCarcinoembryonic Antigen (CEA) in Breast Cancer....................................................................... 26 D. Buffe and C. Rimbaut: a-Fetoprotein (aFP) as a Marker for Hepatoma and Yolk Sac Tumors....................................................................... 33 J. C. Hendrick, P. F. Zangerle, and P. Franchimont: Casein and Breast Cancer ........ 39 A. G. Foti, J. F. Cooper, and H. Herschman: Prostatic Acid Phosphatase and Prostatic Cancer....................................................................... 45 U. Ganzinger and K. M~ser: Sialyl Transferase Activity: A Serum Enzyme Marker in the Follow-Up of Cancer Patients ................................... : . . . . . . . . . . . . . . . 50 A. M. Roch, G. A. Quash, J. P. Ripoll, and S. Saez: Evidence for Natural Antibodies (IgG) to Polyamines in Human Sera..................................................... 56 C. Rosenfeld, C. Jasmin, G. Mathe, and M. Inbar: Dynamic and Composition of Cellular Membranes and Serum Lipids in Malignant Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 R. Maurus and J. Otten: Biologic Markers in Neuroblastoma..... ..... .. ... ... . .. ... 78 R. W. Baldwin, K. Hofiken, and R. A. Robins: Immune Complexes in Breast Carcinoma 85 A. Fassas and M. Bruley-Rosset: Serum Leukocyte Inhibitory Factor in Cancer Patients (Serum LIP) .................................................................. 88 D. E. H. Tee: Clinical Evaluation of the Modified Markari Skin Test in Minimal Residual Malignant Disease. .. .. ... ... .. . .. ..... .. . .. ... ... ... .. . ... .. ..... ... . .. . .. . . .. 93 E. H. Cooper: Multiparametric Markers in the Monitoring of Cancer ... . . . . . . . . . . . . . . 97 VI Contents II. Adjuvant Therapies of Post-Surgical Minimal Residual Disease A. Rational and Experimental Basis of Post-Surgical Residual Therapies M. Tubiana: Post-Surgical Radiotherapy: Rationale and Methods .................... 107 J. Stjernsward: Possible Drawback of Radiotherapy: Rational and Experimental Bases of Post- Surgical Therapies ............................................................. 115 L. M. Van Putten, J. de Ruiter, C. J. H. van de Velde, J. H. Mulder, and A. F. C. Gerritsen: Adjuvant Chemotherapy: Theoretical Considerations and Modal Studies. . . . . . . . . . . . . . 119 Y. Rustum, Y. C. Cheng, Z. Pavelic, P. Creaven, and E. Mihich: Design of Adjuvant Chemo therapy Based on Target Cell Determinants of Drug Action: Possibilities and Limita- tions ......................................................................... 126 G. Mathe, L. Olsson, I. Florentin, N. Kiger, S. Orbach-Arbouys, and J. I. Schulz: Post-Surgi- cal Systematic Active Immunotherapy: Rational and Experimental Basis. . . . . . . . . . . . . . 132 Contents of Volume 68 Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II B. Wilms' Tumor and Sarcomas J. Lemerie, M. F. Tournade, and C. Patte: Wilms' Tumor: Assessment and Treatment of Residual Disease K. Breur and E. van der Schueren: Adjuvant Therapy in the Management of Osteosarcoma: Need for Critical Reassessment E. P. Cortes, J. F. Holland, and O. Glidewell: Adjuvant Therapy ofO perable Primary Osteosarcoma Cancer and Leukemia Group B Experience F. Fossati-Bellani, M. Gasparini, and G. Bonadonna: Adriamycin in the Adjuvant Treatment of Operable Osteosarcoma C. Jasmin: Randomized Trial of Adjuvant Chemotherapy in Osteogenic Osteosarcoma: Comparison of Altering Sequential Administrations of High Doses of Adriamycin, Methotrexate, and Cyclophos phamide with a 6-Month Administration of High-Dose Adriamycin Followed by a Low-Dose Semicontinuous Chemotherapy. EORTC Osteosarcoma Working Party Group W. Wilmanns, H. Sauer, and A. Schalhorn: Biochemistry of the Citrovorum Factor Rescue Effect in Normal Bone Marrow Cells After High-Dose Methotrexate Treatment: Implications for Therapy H. Strander, U. Adamson, T. Aparisi, L. A. Brostrom, K. Cantell, S. Einhorn, K. Hall, S. Ingimars son, U. Nilsonne, and G: SOderberg: Adjuvant Interferon Treatment of Human Osteosarcoma M. Gasparini, F. Fossati-Bellani, and G. Bonadonna: Current Results With a Combined Treatment Approach to Localized Ewing's Sarcoma B. P. Le Mevel et al.: EORTC/GTO Adjuvant Chemotherapy Program for Primary Ewing's Sarcoma: Results at 5 Years V. H. C. Bramwell, P. A. Voiite, S. A. Rosenberg, and H. M. Pinedo: Adjuvant Treatment of Soft Tissue Sarcoma in Children and Adults C. Breast Carcinoma K. E. Halnan: Place and Role of Radiotherapy After Surgery for Breast Cancer A. Rossi, P. Valagussa, and G. Bonadonna: Combined Modality Management of Operable Breast Cancer VIII Contents (Vol. 68) S. E. Salmon, A. Wendt, S. E. Jones, R. Jackson, G. Giordano, R. Miller, R. Heusinkveld, and T. E. Moon: Treatment of Early Breast Cancer with Adriamycin-Cyclophosphamide With or Without Radiation Therapy: Initial Results of a Brief and Effective Adjuvant Program B. Serrou, H. Sancho-Garnier, P. Cappelaere, R. Plagne, R. Metz, M. Schneider, P. Chollet, M. Namer, H. Pujol, J. Gary-Bobo, G. Meyer, and G. Mathe: Results of a Randomized Trial of Prophylactic Chemotherapy in T3-T4 Breast Cancer Patients Previously Treated by Radio therapy G. A. Edelstyn, I. S. Bates, D. Brinkley, K. D. MacRae, H. Spittle, and T. Wheeler: Four Drug Combination Cytotoxic Chemotherapy Following Surgery for Breast Cancer C. Schaake, E. Engelsman, and E. Hamersma: Pilot Study on Adjuvant Chemotherapy and Hor monal Therapy for Irradiated Inoperable Breast Cancer J. W. Meakin, W. E. C. Allt, F. A. Beale, R. S. Bush, R. M. Clark, P. J. Fitzpatrick, N. V. Hawkins, R. D. T. Jenkin, J. F. Pringle, J. G. Reid, and W. D. Rider: Ovarian Irradiation and Prednisone Following Surgery and Radiotherapy for Carcinoma of the Breast A. V. Buzdar, J. U. Gutterman, G. R. Blumenschein, Ch. K. Tashima, G. N. Hortobagyi, H.-Y. Yap, E. M. Hersh, and E. A. Gehan: Adjuvant Therapy of Stage II, III Breast Cancer F. Lacour, G. Delage, A. Spira, E. Nahon-Merlin, J. Lacour, A. M. Michelson, and S. Bayet: Ran domized Trial With Poly A - Poly U as Adjuvant Therapy Complementing Surgery in Patients With Breast Cancer: In vitro Study of Cellular Immunity E. J. W. Stephens, H. F. Wood, and B. Mason: Levamisole: As Adjuvant to Cyclic Chemotherapy in Breast Cancer D. Ovary, Uterus and Testis Cancer C. Mangioni, G. Bolis, M. D. Incalci, P. Molteni, and L. Morasca: Laparoscopy and Peritoneal Cytology as Markers in the Follow-Up of Ovarian Epithelial Tumors D. Chassagne and J. P. Wolff: Radiotherapy in Ovarian Cancer for Post-Surgical Minimal Residual Disease J. H. Edmonson, T. R. Fleming, D. G. Decker, E. O. Jorgensen, G. D. Malkasian, J. A. Jefferies, L. K. Kvols, and M. J. Webb: Chemotherapeutic Sensitivity of Minimal Residual Disease Following Surgical Excision of Ovarian Carcinoma D. S. Alberts, S. E. Salrn,on, and T. E. Moon: Chemoimmunotherapy for Advanced Ovarian Carci noma With Adriamycin-Cyclophosphamide ± BCG: Early Report of a Southwest Oncology Group Study M. E. Crowther, L. Levin, T. A. Poulton, M. J. Saffrey, O. M. Curling, and C. N. Hudson: Active Specific Immunotherapy in Ovarian Cancer T. Taguchi: Clinical Studies on PSK: Combination Therapy ofPSK With Radiation in Cancer of the Uterine Cervix Contents (Vol. 68) IX H. F. Hope-Stone: Irradiation as Adjuvant Therapy in the Management of Testicular Tumors E. Pommatau, C. Ardiet, M. Brunat-Mentigny, J. L. Chassard, and M. Mayer: Adjuvant Chemo therapy in Embryonal Carcinoma of the Testis F. M. Muggia and E. M. Jacobs: Adjuvant Chemotherapy of Testicular Carcinoma: Need for Evalua tion of Curative Strategies M. Hartmann and F. Korner: Results of Cytostatic Therapy of Metastasizing Testicular Tumors E. Digestive Tract Tumors J. C. GofTlll and D. Machin: Treatment of Patients With Gastric Cancer by Surgery, Radiotherapy, and Chemotherapy: Preliminary Results of an EORTC Randomized Study G. R. Giles and J. O. Lawton: Chemotherapy for Known Residual Disease After Resection of Gastric and Colorectal Cancer J. M. Gilbert, P. Cassell, H. Ellis, Ch. Wastell, J. Hermon-Taylor, and K. Hellman: Adjuvant Treat ment With Razoxane (ICRF 159) Following Resection of Cancer of the Stomach T. B. Grage, G. J. Hill, G. N. Cornell, R. W. Frelick, and S. E. Moss: Adjuvant Chemotherapy in Large-Bowel Cancer: Demonstration of Effectiveness of Single Agent Chemotherapy in a Pro spectively Controlled, Randomized Trial P. V. Woolley, G. A. Higgins, and Ph. S. Schein: Ongoing Trials in the Surgical Adjuvant Manage ment of Colorectal Cancer T. Taguchi: Clinical Studies on PSK: Combination Therapy of PSK With Surgery and Chemo therapy F. Bronchus Carcinoma J. Stjernsward: Role of Radiotherapy as an Adjuvant Therapy in Operable Bronchus Carci noma L. Israel, A. Depierre, and R. Sylvester: Influence of Postoperative Radiotherapy on Local Recur rence and Survival of Bronchial Epidermoid Carcinoma With Regard to Nodal Status: Preliminary Results of the EORTC Protocol 08741 L. Israel, A. Depierre, and R. Sylvester: Preliminary Trends ofthe EORTC Study Comparing Post operative Chemotherapy, Immunotherapy, Chemoimmunotherapy or Abstention in Squamous Cell Bronchial Carcinoma K. Karrer: Adjuvant Chemotherapy of Post-Surgical Minimal Residual Bronchial Carcinomas P. Pouillart, T. Palangie, P. Huguenin, P. Morin, H. Gautier, A. Baron, and G. Mathe: Attempt at Immunotherapy With Living BCG in Patients With Bronchus Carcinoma x Contents (Vol. 68) W. K. Amery, J. Cosemans, H. C. Gooszen, E. Lopes Cardozo, A. Louwagie, J. Starn, J. Swierenga, R. G. Vanderschueren, and R. W. Veldhuizen: Adjuvant Therapy With Levamisole in Resectable Lung Cancer T. H. M. Stewart, A. C. Hollinshead, J. E. Harris, S. Raman, R. Belanger, A. Crepeau, A. F. Crook, W. E. Hirte, D. Hooper, D. J. Klaasen, E. F. Rapp, and H. J. Sachs: Specific Active Immunochemo therapy in Lung Cancer: A Survival Study M. F. McKneally, C. Maver, S. Kellar, and L. Lininger: Patterns of Recurrence After Regional BCG Immunotherapy of Bronchial Cancer P. B. lies, D. F. Shore, M. J. S. Langmann, R. W. Baldwin: Intrapleural BCG in Operable Lung Cancer G. Head and Neck Tumors S. G. Taylor, G. A. Sisson, and D. E. Bytell: Adjuvant Chemoimmunotherapy of Head and Neck Cancer H. Szpirglas, C. Chastang, and J. C. Bertrand: Adjuvant Treatment of Tongue and Floor of the Mouth Cancers J. L. Amiel, H. Sancho-Garnier, C. Vandenbrouck, F. Eschwege, J. P. Droz, G. Schwaab, P. Wibault, M. Stromboni, and A. Rey: First Results of a Randomized Trial on Immunotherapy of Head and Neck Tumors H. J. Wanebo,E. Y. Hilal,E. W. Strong,C. M. Pinsky, V. Mike,andH. F. Oettgen: Adjuvant Trial of Levamisole in Patients With Squamous Cancer of the Head and Neck: A Preliminary Report H. Urological Tumors , B. Richards, A. Akdas, P. Corbett, R. W. Glashan, M. R. G. Robinson, and P. A. Smith: Adjuvant Chemotherapy Following Radical Radiotherapy in T3 Bladder Carcinoma C. Schulman, R. Sylvester, M. Robinson, P. Smith, A. Lachand, L. Denis, M. Pavone-Macaluso, M. De Pauw, and M. Staquet: Adjuvant Therapy ofT 1 Bladder Carcinoma: Preliminary Results of an EORTC Randomized Study 1. Melanoma C. Jacquillat, P. Banzet, J. Civatte, P. Puissant, F. Cottenot, L. Israel, S. Belaich, Cl. Chastang, and J. Maral: Adjuvant Chemotherapy or Chemoimmunotherapy in the Management of Primary Malig nant Melanoma of Level III, IV, or V J. U. Gutterman, S. P. Richman, Ch. McBride, M. A. Burgess, S. L. Bartold, A. Kennedy, E. A. Gehan, G. Mavligit, and E. M. Hersh: Immunotherapy for Recurrent Malignant Melanoma: Efficacy ofBCG in Prolonging the Postoperative Disease-Free Interval and Survival
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