Table Of Content

Evidence-Based Complementary and Alternative Medicine Acupuncture and Herbal Medicine for Cancer Patients Guest Editors: S. Schröder, S. Lee, T. Efferth, and Y. Motoo Acupuncture and Herbal Medicine for Cancer Patients Evidence-Based Complementary and Alternative Medicine Acupuncture and Herbal Medicine for Cancer Patients Guest Editors: S. Schro¨der, S. Lee, T. Efferth, and Y. Motoo Copyright©2013HindawiPublishingCorporation.Allrightsreserved. Thisisaspecialissuepublishedin“Evidence-BasedComplementaryandAlternativeMedicine.”Allarticlesareopenaccessarticles distributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninany medium,providedtheoriginalworkisproperlycited. Editorial Board MahmoodAbdulla,Malaysia Jen-HweyChiu,Taiwan Ching-LiangHsieh,Taiwan JonAdams,Australia WilliamC.S.Cho,HongKong JingHu,China ZurainiAhmad,Malaysia JaeYoulCho,Korea GanSiewHua,Malaysia UlyssesAlbuquerque,Brazil Seung-HunCho,RepublicofKorea Sheng-TengHuang,Taiwan GianniAllais,Italy CheeYanChoo,Malaysia BennyTanKwongHuat,Singapore TerjeAlraek,Norway RyowonChoue,RepublicofKorea RomanHuber,Germany SoulimanAmrani,Morocco Shuang-EnChuang,Taiwan AngeloAntonioIzzo,Italy AkshayAnand,India Joo-HoChung,RepublicofKorea KongJ.,USA ShrikantAnant,USA EdwinL.Cooper,USA SureshJadhav,India ManuelArroyo-Morales,Spain GregoryD.Cramer,USA KanokwanJarukamjorn,Thailand SyedAsdaq,SaudiArabia MengCui,China YongJiang,China SeddighehAsgary,Iran RobertoCuman,Brazil ZhengL.Jiang,China HyunsuBae,RepublicofKorea VincenzoDeFeo,Italy StefanieJoos,Germany LijunBai,China Roc´ıoVa´zquez,Spain SirajudeenK.N.S.,Malaysia SandipK.Bandyopadhyay,India MartinDescarreaux,USA Z.Kain,USA SarangBani,India AlexandraDeters,Germany OsamuKanauchi,Japan VassyaBankova,Bulgaria SivaDurairajan,HongKong WenyiKang,China WinfriedBanzer,Germany MohamedEddouks,Morocco DaeGillKang,RepublicofKorea VernonA.Barnes,USA ThomasEfferth,Germany Shao-HsuanKao,Taiwan SamraBashir,Pakistan TobiasEsch,Germany KrishnaKaphle,Nepal JairoKenuppBastos,Brazil SaeedEsmaeili-Mahani,Iran KenjiKawakita,Japan SujitBasu,USA NianpingFeng,China JongYeolKim,RepublicofKorea DavidBaxter,NewZealand YibinFeng,HongKong Cheorl-HoKim,RepublicofKorea Andre-MichaelBeer,Germany JosueFernandez-Carnero,Spain YounChulKim,RepublicofKorea AlvinJ.Beitz,USA JulianoFerreira,Brazil YoshiyukiKimura,Japan YongBoo,RepublicofKorea FabioFirenzuoli,Italy JoshuaK.Ko,China FrancescaBorrelli,Italy PeterFisher,UK ToshiakiKogure,Japan GloriaBrusotti,Italy W.F.Fong,HongKong NandakumarKrishnadas,India IshfaqA.Bukhari,Pakistan RomainForestier,France YiuWaKwan,HongKong ArndtBu¨ssing,Germany JoelJ.Gagnier,Canada KuangChiLai,Taiwan RainerW.Bussmann,USA Jian-LiGao,China ChingLan,Taiwan RaffaeleCapasso,Italy GabinoGarrido,Chile AlfredLa¨ngler,Germany OpherCaspi,Israel MuhammadGhayur,Pakistan LixingLao,HongKong HanChae,Korea AnwarulHassanGilani,Pakistan ClaraBik-SanLau,HongKong Shun-WanChan,HongKong MichaelGoldstein,USA Jang-HernLee,RepublicofKorea Il-MooChang,RepublicofKorea MahabirP.Gupta,Panama TatleangLee,Singapore RajnishChaturvedi,India MitchellHaas,USA MyeongS.Lee,UK ChunTaoChe,USA SveinHaavik,Norway ChristianLehmann,Canada HubiaoChen,HongKong AbidHamid,India MarcoLeonti,Italy Jian-GuoChen,China N.Hanazaki,Brazil Ping-ChungLeung,HongKong KevinChen,USA K.B.Harikumar,India LawrenceLeung,Canada Tzeng-JiChen,Taiwan CoryS.Harris,Canada KwokNamLeung,HongKong YunfeiChen,China ThierryHennebelle,France PingLi,China Juei-TangCheng,Taiwan Seung-HeonHong,Korea MinLi,China EvanPaulCherniack,USA MarkusHorneber,Germany ManLi,China ChunGuangLi,Australia AndreaPieroni,Italy MeiTian,China Xiu-MinLi,USA RichardPietras,USA EvelinTiralongo,Australia ShaoLi,China WarisQidwai,Pakistan S.C.Tjen-A-Looi,USA YongHongLiao,China XianqinQu,Australia MichaThlTomczyk,Poland SabinaLim,Korea CassandraL.Quave,USA YaoTong,HongKong Bi-FongLin,Taiwan RojaRahimi,Iran K.V.Trinh,Canada WenChuanLin,China KhalidRahman,UK KarlWah-KeungTsim,HongKong ChristopherG.Lis,USA CheppailRamachandran,USA VolkanTugcu,Turkey GerhardLitscher,Austria GamalRamadan,Egypt Yew-MinTzeng,Taiwan KeLiu,China KeRen,USA DawnM.Upchurch,USA I-MinLiu,Taiwan ManHeeRhee,RepublicofKorea MarynaVandeVenter,SouthAfrica GaofengLiu,China Mee-RaRhyu,RepublicofKorea SandyvanVuuren,SouthAfrica YijunLiu,USA Jose´LuisR´ıos,Spain AlfredoVannacci,Italy Cun-ZhiLiu,China PaoloRobertidiSarsina,Italy ManiVasudevan,Malaysia GailB.Mahady,USA BasharSaad,PalestinianAuthority CarloVentura,Italy JurajMajtan,Slovakia SumairaSahreen,Pakistan WagnerVilegas,Brazil SubhashC.Mandal,India OmarSaid,Israel PradeepVisen,Canada JeanineMarnewick,SouthAfrica LuisA.Salazar-Olivo,Mexico AristoVojdani,USA VirginiaS.Martino,Argentina Mohd.ZakiSalleh,Malaysia Y.Wang,USA JamesH.McAuley,Australia AndreasSandner-Kiesling,Austria Shu-MingWang,USA KarinMeissner,USA AdairSantos,Brazil ChenchenWang,USA AndreasMichalsen,Germany G.Schmeda-Hirschmann,Chile Chong-ZhiWang,USA DavidMischoulon,USA AndrewScholey,Australia KenjiWatanabe,Japan SyamMohan,Malaysia VeroniqueSeidel,UK JintanapornWattanathorn,Thailand J.Molnar,Hungary SenthamilR.Selvan,USA WolfgangWeidenhammer,Germany Vale´rioMonteiro-Neto,Brazil TuhinadriSen,India JennyM.Wilkinson,Australia H.-I.Moon,RepublicofKorea HongcaiShang,China DarrenWilliams,RepublicofKorea AlbertMoraska,USA KarenJ.Sherman,USA HarukiYamada,Japan MarkMoss,UK RonaldSherman,USA NobuoYamaguchi,Japan YoshiharuMotoo,Japan KuniyoshiShimizu,Japan Yong-QingYang,China FraukeMusial,Germany KanShimpo,Japan JunqingYang,China MinKyunNa,RepublicofKorea Byung-CheulShin,Korea LingYang,China RichardL.Nahin,USA YukihiroShoyama,Japan EunJinYang,RepublicofKorea VitalyNapadow,USA ChangGueSon,Korea XiufenYang,China F.R.F.Nascimento,Brazil RachidSoulimani,France KenYasukawa,Japan S.Nayak,TrinidadAndTobago DidierStien,France MinH.Ye,China IsabellaNeri,Italy Shan-YuSu,Taiwan M.Yoon,RepublicofKorea Te´lesphoreNguelefack,Cameroon MohdRoslanSulaiman,Malaysia JieYu,China MartinOffenbacher,Germany VenilN.Sumantran,India Jin-LanZhang,China Ki-WanOh,RepublicofKorea JohnR.S.Tabuti,Uganda ZunjianZhang,China Y.Ohta,Japan TokuTakahashi,USA Wei-boZhang,China OlumayokunA.Olajide,UK RabihTalhouk,Lebanon HongQ.Zhang,HongKong ThomasOstermann,Germany Wen-FuTang,China BoliZhang,China StaceyA.Page,Canada YupingTang,China RuixinZhang,USA Tai-LongPan,Taiwan LayKekTeh,Malaysia HongZhang,Sweden BhushanPatwardhan,India MayankThakur,India HaiboZhu,China BeritSmestadPaulsen,Norway MenakaC.Thounaojam,India Contents AcupunctureandHerbalMedicineforCancerPatients,S.Schro¨der,S.Lee,T.Efferth,andY.Motoo Volume2013,ArticleID313751,5pages ASurveyofChineseMedicinalHerbalTreatmentforChemotherapy-InducedOralMucositis, GesaMeyer-Hamme,KathrinBeckmann,JanineRadtke,ThomasEfferth,HenryJohannesGreten, MatthiasRostock,andSvenSchro¨der Volume2013,ArticleID284959,16pages PotentialTherapeuticRoleofHispidulininGastricCancerthroughInductionofApoptosisviaNAG-1 Signaling,ChaoYuanYu,Kang-YiSu,Po-LeiLee,Jie-YuJhan,Po-HungTsao,De-ChuanChan, andYi-LinSophiaChen Volume2013,ArticleID518301,12pages Chemotherapy-InducedPeripheralNeuropathyinCancerPatients:AFour-ArmRandomizedTrialon theEffectivenessofElectroacupuncture,M.Rostock,K.Jaroslawski,C.Guethlin,R.Ludtke,S.Schro¨der, andH.H.Bartsch Volume2013,ArticleID349653,9pages CanMedicalHerbsStimulateRegenerationorNeuroprotectionandTreatNeuropathicPainin Chemotherapy-InducedPeripheralNeuropathy?,SvenSchro¨der,KathrinBeckmann,GiovannaFranconi, GesaMeyer-Hamme,ThomasFriedemann,HenryJohannesGreten,MatthiasRostock,andThomasEfferth Volume2013,ArticleID423713,18pages ASystematicReviewofExperimentalandClinicalAcupunctureinChemotherapy-InducedPeripheral Neuropathy,GiovannaFranconi,LuigiManni,SvenSchro¨der,PaoloMarchetti,andNicolaRobinson Volume2013,ArticleID516916,7pages AntiangiogenicActivityandPharmacogenomicsofMedicinalPlantsfromTraditionalKorean Medicine,Ean-JeongSeo,VictorKuete,OnatKadioglu,BenjaminKrusche,SvenSchro¨der, HenryJohannesGreten,JoachimArend,Ik-SooLee,andThomasEfferth Volume2013,ArticleID131306,13pages ChineseMedicinesasanAdjuvantTherapyforUnresectableHepatocellularCarcinomaduring TransarterialChemoembolization:AMeta-AnalysisofRandomizedControlledTrials,FanCheung, XuanbinWang,NingWang,Man-FungYuen,Tat-chiZiea,YaoTong,VivianTaamWong,andYibinFeng Volume2013,ArticleID487919,25pages DistributionsofUsageandtheCostsofConventionalMedicineandTraditionalChineseMedicinefor LungCancerPatientsinTaiwan,Yueh-HsiangLiao,Jaung-GengLin,Cheng-ChiehLin,andTsai-ChungLi Volume2013,ArticleID984876,11pages CytotoxicityandPharmacogenomicsofMedicinalPlantsfromTraditionalKoreanMedicine, VictorKuete,Ean-JeongSeo,BenjaminKrusche,MiraOswald,BenjaminWiench,SvenSchro¨der, HenryJohannesGreten,Ik-SooLee,andThomasEfferth Volume2013,ArticleID341724,14pages TherapeuticApplicationsofHerbalMedicinesforCancerPatients,Shu-YiYin,Wen-ChiWei, Feng-YinJian,andNing-SunYang Volume2013,ArticleID302426,15pages TraditionalHerbalMedicine:AReviewofPotentialofInhibitoryHepatocellularCarcinomainBasic ResearchandClinicalTrial,ZhidongWang,JunLi,YuanyuanJi,PengAn,ShuZhang,andZongfangLi Volume2013,ArticleID268963,7pages RoleofKampoMedicineinIntegrativeCancerTherapy,Jun-ichiYamakawa,YoshiharuMotoo, JunjiMoriya,MasaoOgawa,HiroakiUenishi,SumiyoAkazawa,ToshiyukiSasagawa,MatomoNishio, andJunjiKobayashi Volume2013,ArticleID570848,6pages HemiparesisafterOperationofAstrocytomaGradeIIinAdults:EffectsofAcupunctureon Sensory-MotorBehaviorandQualityofLife,HaiboYu,SvenSchro¨der,YongfengLiu,ZhifengLi, YingYang,YuChen,andXingxianHuang Volume2013,ArticleID859763,13pages IntegrationofDifferent“-omics”TechnologiesIdentifiesInhibitionoftheIGF1R-Akt-mTORSignaling CascadeInvolvedintheCytotoxicEffectofShikoninagainstLeukemiaCells,BenjaminWiench, Yet-RanChen,MaltePaulsen,RebeccaHamm,SvenSchro¨der,Ning-SunYang,andThomasEfferth Volume2013,ArticleID818709,11pages SignificanceofKampo,TraditionalJapaneseMedicine,inSupportiveCareofCancerPatients, Jun-ichiYamakawa,YoshiharuMotoo,JunjiMoriya,MasaoOgawa,HiroakiUenishi,SumiyoAkazawa, ToshiyukiSasagawa,MatomoNishio,andJunjiKobayashi Volume2013,ArticleID746486,10pages CucurbitaneTriterpenoidfromMomordicacharantiaInducesApoptosisandAutophagyinBreast CancerCells,inPart,throughPeroxisomeProliferator-ActivatedReceptor𝛾Activation,Jing-RuWeng, Li-YuanBai,Chang-FangChiu,Jing-LanHu,Shih-JiuanChiu,andChia-YungWu Volume2013,ArticleID935675,12pages HerbalMedicineandAcupunctureforBreastCancerPalliativeCareandAdjuvantTherapy, Guo-ShiouLiao,MariaKarmellaApaya,andLie-FenShyur Volume2013,ArticleID437948,17pages JuzentaihotoFailedtoAugmentAntigen-SpecificImmunitybutPreventedDeteriorationofPatients’ ConditionsinAdvancedPancreaticCancerunderPersonalizedPeptideVaccine,ShigeruYutani, NobukazuKomatsu,SatokoMatsueda,MunehiroYoshitomi,TakahisaShirahama,AkiraYamada, KyogoItoh,andTetsuroSasada Volume2013,ArticleID981717,10pages TherapeuticEffectsofSaireito(Chai-Ling-Tang),aTraditionalJapaneseHerbalMedicine,on LymphedemaCausedbyRadiotherapy:ACaseSeriesStudy,AikoNagai,YutaShibamoto, andKeikoOgawa Volume2013,ArticleID241629,6pages LessonsLearntfromEvidence-BasedApproachofUsingChineseHerbalMedicinesinLiverCancer, ZhanZheng,WilliamChi-ShingCho,LingXu,JuyongWang,andDanielMan-YuenSze Volume2013,ArticleID656351,11pages TetrandrineSuppressesCancerAngiogenesisandMetastasisin4T1TumorBearingMice,Jian-LiGao, XingJi,Tong-ChuanHe,QiZhang,KaiHe,YanZhao,Su-HongChen,andGui-YuanLv Volume2013,ArticleID265061,12pages EfficacyofContactNeedleTherapyforChemotherapy-InducedPeripheralNeuropathy,KeikoOgawa, MasaoOgawa,KojiNishijima,MasakiTsuda,andGenichiNishimura Volume2013,ArticleID928129,5pages PrenylatedFlavonoidsfromMorusalbaL.CauseInhibitionofG1/STransitioninTHP-1Human LeukemiaCellsandPreventtheLipopolysaccharide-InducedInflammatoryResponse,PeterKollar, Toma´ˇsBˇsrta,JanHoˇsek,KarelSoucˇek,VeronikaMu¨llerZa´valova´,ShushanArtinian,RabihTalhouk, KarelSˇmejkal,PavelSuchy´Jr.,andAleˇsHampl Volume2013,ArticleID350519,13pages ImpactofStandardizedAllergen-RemovedRhusvernicifluaStokesExtractonAdvanced AdenocarcinomaoftheAmpullaofVater:ACaseSeries,WoncheolChoi,SoominAn,EunmiKwon, WankyuEo,andSanghunLee Volume2013,ArticleID203168,8pages HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2013,ArticleID313751,5pages http://dx.doi.org/10.1155/2013/313751 Editorial Acupuncture and Herbal Medicine for Cancer Patients S.Schröder,1S.Lee,2T.Efferth,3andY.Motoo4 1HanseMerkurCenterforTraditionalChineseMedicine,UniversityMedicalCenterHamburg-Eppendorf, 20246Hamburg,Germany 2DepartmentofClinicalOncology,CollegeofKoreanMedicine,KyungHeeUniversity,Seoul130-701,RepublicofKorea 3DepartmentofPharmaceuticalBiology,InstituteofPharmacyandBiochemistry,JohannesGutenbergUniversity, StaudingerWeg5,55128Mainz,Germany 4DepartmentofMedicalOncology,KanazawaMedicalUniversity,Uchinada,Ishikawa920-0293,Japan CorrespondenceshouldbeaddressedtoY.Motoo;[email protected] Received27October2013;Accepted27October2013 Copyright©2013S.Schro¨deretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. 1.ComplementaryandAlternativeMedicine InKorea,78.5%ofcancerpatientsuseCAM[9].AJapanese (CAM)inCancerCare study revealed that 44.6% of cancer patients use CAM [10], while 83% of cancer patients or cancer survivors use In recent decades, cancer treatment has made remarkable CAMtreatmentsinAustralia[11].AnEuropeansurveyin13 progress with targeted therapy applied on targeted subpop- countriesshowed35.9%ofaverageCAMprevalenceincancer ulation[1].Thoughthelifeexpectancyofthegeneralpopu- patients(rangeamongcountries14.8%to73.1%)[12].Inother lationisincreasing,cancerisstilloneofthemostcommon partsoftheworldsimilarresultswereobtained[13].CAMis causesofdeathworldwide[2].Thesophisticatedtreatments alsousedby31–84%ofchildrenwithcancer[14].Thisusage are often accompanied with increased adverse events, and ofCAMforcancerismorecommonamongeducatedpeople the survival rate is still unsatisfactory in some cancers. In withbetterhealthbehaviour[15,16]aswellasamongwomen advancedorrecurrentcancers,thegoalofcancertreatment [17].Inthecaseoffemalecancers,morepatientsuseCAM; isoftennotcuringthediseasebutprolongingsurvivaltime forexample,60–80%ofbreastcancerpatients(incomparison with good quality of life. The health-related quality of life to50%amongcancerpatientsingeneral)and75%offemale is getting value as a cancer outcome, and the effect of coloncancerpatientsuseCAM[18]. earlypalliativecareisemphasizedimportantly[3].Nowadays Patients mostly use CAM as a complement to their medicalinformationiseasilyaccessedbypatients,andmost conventional therapy, not as an alternative treatment [19]. of patients are looking for treatments with less side effects Only very few patients replace conventional treatment by and all available information to prolong survival time and alternativemedicine[20].EventhoughtheuseofCAMisa to improve quality of life. Therefore, complementary and factworldwide,theviewonCAMvariesenormously,andthe alternativemedicine(CAM)forcancerisincreasinglybeing integrationofCAMtherapiesintoconventionaltherapiesis demanded by patients, and more physicians are getting extremelycomplicatedindifferentcountries. interestedintheuseofCAMincancertherapies. Although the governmental support on the research on TheuseofCAMincancertherapiesdiffersfromcountry CAM for cancer therapies differs among various countries, tocountry,butupto80%ofcancerpatientsusesomekindsof the use of CAM for cancer patients is still debated in an CAMtosupporttheirconventionalcancertreatments[4,5]. ideologicalwaybysupportersandopponentsofCAM.One In Southwestern China, the prevalence of Chinese herbal ofthecausesforthereluctanceofWesternacademiatowards medicine use is up to 53.0% during cancer treatment [6], CAM is still the insufficient number of convincing clinical and it seems similar to that of Hong Kong [7]. In Taiwan, studies providing evidence for the efficacy and safety of up to 98% of the cancer patients use any kind of CAM [8]. CAM therapies. The Western concept of “evidence-based