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National Institute on Drug Abuse Activation of Immediate Early Genes by Drugs Abuse of US. DEPARTMENTOF HEALTH AND HUMAN SERVICES • Public Health Service • National Institutes of Health UBRA.RV ppu ruclww^i£lR* RESEARCH AnniCTlON MAWLhiND BALTIMORE, Activation of Immediate Genes By Drugs Early of Abuse Editors: NATIONAL INSTITUTES OF HEALTH Reinhard Grzanna, Ph.D. NIH LIBRARY Roger M. Brown, Ph.D. APR 2 5 2007 BLDG 10, 10 CENTER DR BETHESDA, MD. 20892-1150 NIDA Research Monograph 125 1993 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 ACKNOWLEDGMENT This monograph is based on the papers and discussions from a technical review on “Activation of Immediate Early Genes by Drugs ofAbuse” held on June 3-4, 1991 in Rockville, MD. The technical review was sponsored by the , National Institute on Drug Abuse (NIDA). COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published material as noted in the text. Further reproduction ofthis copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors. Citation of the source is appreciated. Opinions expressed in this volume are those ofthe authors and do not necessarily reflect the opinions or official policy ofthe National Institute on Drug Abuse or any other part of the U.S. Department of Health and Human Services. The U.S. Government does not endorse orfavor any specific commercial product or company. Trade, proprietary, or company names appearing in this publication are used only because they are considered essential in the context of the studies reported herein. NIDA Research Monographs are indexed in the “Index Medicus.” They are selectively included in the coverage of “American Statistics Index,” “BioSciences Information Service,” “Chemical Abstracts,” “Current Contents,” “Psychological Abstracts,” and “Psychopharmacology Abstracts.” National Institute on Drug Abuse NIH Publication No. 93-3504 Printed 1993 n Contents Pape Introduction 1 Reinhard Grzanna andRogerM. Brown Regulation of Immediate Early Gene Expression 3 BrentH. Cochran Everything Activates C-fos—How Can Matter? 25 It Steven E. Hyman BarryE. Kosofsky, Tuong V. Nguyen, , Bruce M. Cohen, andMichaelJ. Comb Immediate Early Genes: Their Involvement in Physiological and Pathological Responses in the Nervous System 39 MichaelD. Hayward, Tom Curran, andJames Morgan I. Immediate Early Gene Activation and Long-Term Changes in Neural Function: A Possible Role in Addiction? 54 HaroldA. Robertson Acute Effects of Psychomotor Stimulant Drugs on Gene Expression in the Striatum 72 Ann M. Graybiel Functional Organization ofthe Striatum: Relevance to Actions of Psychostimulant Drugs ofAbuse 82 Charles R. Gerfen iii Regulation of Neural Gene Expression in Opiate and Cocaine Addiction 92 EricJ. Nastier Clare M. Bergson, XavierGuitart, , andBruce T. Hope C-Fos and Fos-Related Antigens as Markers for Neuronal Activity: Perspectives From Neuroendocrine Systerps 117 Gloria E. Hoffman Wen-Sen Lee, M. Susan Smith, RulaAbbud, , Michelle M. Roberts, Alan G. Robinson, andJoseph G. Verbalis Mechanisms of Opioid-Mediated Antinociception: Correlation of Fos Expression and Behavior 134 Kathleen R. Gogas, Jon D. Levine, andAllan Basbaum I. The Ontogeny of Immediate Early Gene Response to Cocaine: A Molecular Analysis ofthe Effects of Cocaine on Developing Rat Brain 161 BarryE. Kosofskyand Steven E. Hyman NMDA Receptor Blockade Prevents Translation, but Not Transcription, ofthe C-fosGene Following Stimulation With Multiple Extracellular Signals in Cultured Cortical Neurons: Implications for Plasticity and Molecular Memory 172 Frank R. Sharp, Kinya Hisanaga, and Stephen M. Sagar Induction and Suppression of Proto-Oncogenes in Rat Striatum After Single or Multiple Treatments With Cocaine or GBR-12909 181 MichaelJ. ladarola, EricJ. Chuang, Choh-Lun Yeung, Yin Hoo, Mayme Silverthorn, Jun Gu, and Gaetano Draisci List of N DA Research Monographs 212 I iv