ABC of clinical haematology 4th edition PDF
Preview ABC of clinical haematology 4th edition
Clinical Haematology Fourth Edition Clinical Haematology Fourth Edition EDITED BY Drew Provan Emeritus Reader in Autoimmune Haematology Department of Haematology Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK This fourth edition first published 2018 © 2018 by John Wiley & Sons Ltd Edition History John Wiley & Sons Ltd (3e, 2009) All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions. The right of Drew Provan to be identified as the author of the editorial material in this work has been asserted in accordance with law. 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Title: ABC of clinical haematology / edited by Drew Provan. Description: Fourth edition. | Hoboken, NJ : John Wiley & Sons, Inc., 2018. | Includes bibliographical references and index. | Identifiers: LCCN 2017055360 (print) | LCCN 2017056756 (ebook) | ISBN 9781118892473 (pdf) | ISBN 9781118892480 (epub) | ISBN 9781118892343 (pbk.) Subjects: | MESH: Hematologic Diseases–diagnosis | Hematologic Diseases–therapy | Hematologic Diseases–physiopathology Classification: LCC RC633 (ebook) | LCC RC633 (print) | NLM WH 120 | DDC 616.1/5–dc23 LC record available at https://lccn.loc.gov/2017055360 Cover Design: Wiley Cover Image: © Science Photo Library - STEVE GSCHMEISSNER./Gettyimages Set in 9.25/12pt Minion by SPi Global, Pondicherry, India 10 9 8 7 6 5 4 3 2 1 Contents Contributors, vii 1 Iron‐Deficiency Anaemia, 1 Drew Provan and Catherine Booth 2 Macrocytic Anaemias, 7 Victor Hoffbrand 3 The Hereditary Anaemias, 13 David J. Weatherall 4 Polycythaemia Vera, Essential Thrombocythaemia and Myelofibrosis, 21 Anna L. Godfrey, George S. Vassiliou and Anthony R. Green 5 Chronic Myeloid Leukaemia, 27 Jenny L. Byrne 6 The Acute Leukaemias, 33 John de Vos, Sandra Hassan and Julia Sikorska 7 Platelet Disorders, 41 Marie A. Scully and R. J. Liesner 8 Myelodysplastic Syndromes, 49 Ghulam J. Mufti and Robin Dowse 9 Multiple Myeloma, 55 Sandra Hassan and Jamie Cavenagh 10 Bleeding Disorders, Thrombosis and Anticoagulation, 61 David M. Keeling 11 Lymphoproliferative Disorders, 67 Catherine Hockings and Christopher McNamara 12 Stem Cell Transplantation, 75 Sandra Hassan and John de Vos 13 Haematological Problems in Older Adults, 81 Tom Butler and Adrian C. Newland 14 Haematological Emergencies, 85 Igor Novitzky‐Basso and Jim Murray 15 The Future of Haematology: The Impact of Molecular Biology and Gene Therapy, 93 Katharine Bailey, Richard Burt and Adele K. Fielding Index, 99 v Contributors Katharine Bailey Sandra Hassan Haematology, Cancer Institute, UCL, Royal Free Campus, London, UK Consultant Haematologist, Queen’s Hospital, BHR NHS Trust, Romford, UK Catherine Booth Catherine Hockings Specialist Registrar in Haematology, Barts and the London NHS Trust, Department of Haematology, University College London Hospitals NHS London, UK Foundation Trust, London, UK Victor Hoffbrand Richard Burt Emeritus Professor of Haematology, University College London, London, UK Haematology, Cancer Institute, UCL, Royal Free Campus, London, UK David M. Keeling Tom Butler Consultant Haematologist, Oxford University Hospitals, Oxford Department of Clinical Haematology, Barts Health NHS Trust, Haemophilia & Thrombosis Centre, Churchill Hospital, Oxford, UK Pathology & Pharmacy Building, Royal London Hospital, London, UK R. J. Liesner Jenny L. Byrne Director Haemophilia CCC, Great Ormond Street Hospital, London, UK Nottingham University Hospitals NHS Trust, Nottingham, UK Christopher McNamara Jamie Cavenagh Department of Haematology, University College London Hospitals NHS Consultant Haematologist, Department of Haemato‐Oncology, Foundation Trust, London, UK St Bartholomew’s Hospital, West Smithfield, London, UK Ghulam J. Mufti John de Vos Professor of Haemato‐oncology & Head of Department, Haematological Consultant Haematologist, Royal Surrey County Hospital NHS Foundation Medicine, King’s College Hospital NHS Foundation Trust, Trust, Guildford, UK Hambleden Wing, London, UK Jim Murray Robin Dowse Haematology – University Hospitals Birmingham NHS Foundation Senior Specialist Registrar, Haematological Medicine, King’s College Hospital Trust, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, NHS Foundation Trust, Hambleden Wing, London, UK Birmingham, UK Adele K. Fielding Adrian C. Newland Haematology, Cancer Institute, UCL, Royal Free Campus, Barts and the London Medical School, Queen Mary University of London; London, UK Department of Clinical Haematology, Barts Health NHS Trust, Pathology & Pharmacy Building, Royal London Hospital, London, UK Anna L. Godfrey Consultant Haematologist, Department of Haematology, Igor Novitzky‐Basso Cambridge University Hospitals NHS Foundation Trust, Stem Cell Laboratory Medical Director, Queen Elizabeth University Hospital Cambridge, UK Glasgow, NHS Greater Glasgow and Clyde, Glasgow, UK Anthony R. Green Drew Provan Director, Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Emeritus Reader in Autoimmune Haematology, Department of Cambridge; Haematology, Barts and The London School of Medicine and Dentistry, Department of Haematology, University of Cambridge, Cambridge, UK Queen Mary University of London, London, UK vii viii Contributors Marie A. Scully George S. Vassiliou Department of Haematology, University College London Hospitals NHS Group Leader and Consultant Haematologist, Wellcome Trust Sanger Trust, Cardiometabolic Programme‐NIHR UCLH/UCL BRC, Institute, Wellcome Genome Campus, Hinxton; London, UK Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK Julia Sikorska David J. Weatherall Specialist Registrar in Haematology, Royal Surrey County Hospital NHS Regius Professor of Medicine Emeritus, MRC Weatherall Institute of Foundation Trust, Guildford, UK Molecular Medicine, University of Oxford, Headington, Oxford, UK
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