ABC of clinical haematology 4th edition

114 Pages·2019·14.45 MB·Russian

by  Drew Provan

Clinical Haematology
Fourth Edition

Clinical
Haematology
Fourth Edition
EDITED BY
Drew Provan
Emeritus Reader in Autoimmune Haematology
Department of Haematology
Barts and The London School of Medicine and Dentistry
Queen Mary University of London
London
UK
This fourth edition first published 2018 © 2018 by John Wiley & Sons Ltd
Edition History
John Wiley & Sons Ltd (3e, 2009)
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Library of Congress Cataloging‐in‐Publication Data
Names: Provan, Drew, 1955– editor.
Title: ABC of clinical haematology / edited by Drew Provan.
Description: Fourth edition. | Hoboken, NJ : John Wiley & Sons, Inc., 2018. | Includes bibliographical
references and index. |
Identifiers: LCCN 2017055360 (print) | LCCN 2017056756 (ebook) | ISBN 9781118892473 (pdf) |
ISBN 9781118892480 (epub) | ISBN 9781118892343 (pbk.)
Subjects: | MESH: Hematologic Diseases–diagnosis | Hematologic Diseases–therapy |
Hematologic Diseases–physiopathology
Classification: LCC RC633 (ebook) | LCC RC633 (print) | NLM WH 120 | DDC 616.1/5–dc23
LC record available at https://lccn.loc.gov/2017055360
Cover Design: Wiley
Cover Image: © Science Photo Library - STEVE GSCHMEISSNER./Gettyimages
Set in 9.25/12pt Minion by SPi Global, Pondicherry, India
10 9 8 7 6 5 4 3 2 1
Contents
Contributors, vii
1 Iron‐Deficiency Anaemia, 1
Drew Provan and Catherine Booth
2 Macrocytic Anaemias, 7
Victor Hoffbrand
3 The Hereditary Anaemias, 13
David J. Weatherall
4 Polycythaemia Vera, Essential Thrombocythaemia and Myelofibrosis, 21
Anna L. Godfrey, George S. Vassiliou and Anthony R. Green
5 Chronic Myeloid Leukaemia, 27
Jenny L. Byrne
6 The Acute Leukaemias, 33
John de Vos, Sandra Hassan and Julia Sikorska
7 Platelet Disorders, 41
Marie A. Scully and R. J. Liesner
8 Myelodysplastic Syndromes, 49
Ghulam J. Mufti and Robin Dowse
9 Multiple Myeloma, 55
Sandra Hassan and Jamie Cavenagh
10 Bleeding Disorders, Thrombosis and Anticoagulation, 61
David M. Keeling
11 Lymphoproliferative Disorders, 67
Catherine Hockings and Christopher McNamara
12 Stem Cell Transplantation, 75
Sandra Hassan and John de Vos
13 Haematological Problems in Older Adults, 81
Tom Butler and Adrian C. Newland
14 Haematological Emergencies, 85
Igor Novitzky‐Basso and Jim Murray
15 The Future of Haematology: The Impact of Molecular Biology and Gene Therapy, 93
Katharine Bailey, Richard Burt and Adele K. Fielding
Index, 99
v

Contributors
Katharine Bailey Sandra Hassan
Haematology, Cancer Institute, UCL, Royal Free Campus, London, UK Consultant Haematologist, Queen’s Hospital, BHR NHS Trust, Romford, UK
Catherine Booth Catherine Hockings
Specialist Registrar in Haematology, Barts and the London NHS Trust, Department of Haematology, University College London Hospitals NHS
London, UK Foundation Trust, London, UK
Victor Hoffbrand
Richard Burt
Emeritus Professor of Haematology, University College London, London, UK
Haematology, Cancer Institute, UCL, Royal Free Campus, London, UK
David M. Keeling
Tom Butler
Consultant Haematologist, Oxford University Hospitals, Oxford
Department of Clinical Haematology, Barts Health NHS Trust,
Haemophilia & Thrombosis Centre, Churchill Hospital, Oxford, UK
Pathology & Pharmacy Building, Royal London Hospital, London, UK
R. J. Liesner
Jenny L. Byrne
Director Haemophilia CCC, Great Ormond Street Hospital, London, UK
Nottingham University Hospitals NHS Trust, Nottingham, UK
Christopher McNamara
Jamie Cavenagh
Department of Haematology, University College London Hospitals NHS
Consultant Haematologist, Department of Haemato‐Oncology, Foundation Trust, London, UK
St Bartholomew’s Hospital, West Smithfield, London, UK
Ghulam J. Mufti
John de Vos Professor of Haemato‐oncology & Head of Department, Haematological
Consultant Haematologist, Royal Surrey County Hospital NHS Foundation Medicine, King’s College Hospital NHS Foundation Trust,
Trust, Guildford, UK Hambleden Wing, London, UK
Jim Murray
Robin Dowse
Haematology – University Hospitals Birmingham NHS Foundation
Senior Specialist Registrar, Haematological Medicine, King’s College Hospital
Trust, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre,
NHS Foundation Trust, Hambleden Wing, London, UK
Birmingham, UK
Adele K. Fielding
Adrian C. Newland
Haematology, Cancer Institute, UCL, Royal Free Campus,
Barts and the London Medical School, Queen Mary University of London;
London, UK
Department of Clinical Haematology, Barts Health NHS Trust, Pathology &
Pharmacy Building, Royal London Hospital, London, UK
Anna L. Godfrey
Consultant Haematologist, Department of Haematology, Igor Novitzky‐Basso
Cambridge University Hospitals NHS Foundation Trust, Stem Cell Laboratory Medical Director, Queen Elizabeth University Hospital
Cambridge, UK Glasgow, NHS Greater Glasgow and Clyde, Glasgow, UK
Anthony R. Green Drew Provan
Director, Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Emeritus Reader in Autoimmune Haematology, Department of
Cambridge; Haematology, Barts and The London School of Medicine and Dentistry,
Department of Haematology, University of Cambridge, Cambridge, UK Queen Mary University of London, London, UK
vii
viii Contributors
Marie A. Scully George S. Vassiliou
Department of Haematology, University College London Hospitals NHS Group Leader and Consultant Haematologist, Wellcome Trust Sanger
Trust, Cardiometabolic Programme‐NIHR UCLH/UCL BRC, Institute, Wellcome Genome Campus, Hinxton;
London, UK Wellcome Trust/MRC Cambridge Stem Cell Institute, University of
Cambridge, Cambridge, UK
Julia Sikorska
David J. Weatherall
Specialist Registrar in Haematology, Royal Surrey County Hospital NHS
Regius Professor of Medicine Emeritus, MRC Weatherall Institute of
Foundation Trust, Guildford, UK
Molecular Medicine, University of Oxford, Headington, Oxford, UK