63 rd ASMS Conference on Mass Spectrometry and Allied Topics, St. Louis, MO, USA

236 Pages·2015·3.8 MB·English

63RD ASMS C M s a t
onferenCe on ass peCtroMetry and llied opiCs
May 31 - June 4, 2015 • St. LouiS, MiSSouri
Welcome to the 63rd ASMS Conference on Mass Spectrometry and Allied Topics. Conference program
activities and exhibit booths are in America’s Center. Corporate Member hospitality suites are located in the
Renaissance Grand Hotel.
SponSorS
Table of ConTenTS
ASMS gratefully acknowledges the support
of these companies.
General InformaTIon .......................................2
HoTelS ..............................................................5
aSmS board of dIreCTorS ............................6
InTereST GroupS and CommITTeeS ..................7
awardS..............................................................8
Mobile App and WiFi
ConvenTIon CenTer floor planS ................11
CorporaTe HoSpITalITy SuITeS .....................13
aSmS CorporaTe memberS .........................14
Opening Reception proGram aCknowledGemenTS .......................19
proGram overvIew ........................................20
workSHopS .....................................................25
Closing Event
Titles in the following sections are provided by authors. The
complete abstracts are available online: www.asms.org
Closing Event The PDF document of proceedings submissions for orals and
posters may be viewed online one day after presentation at the
conference.
ConferenCe SponSor
Sunday ............................................................32
monday oral SeSSIonS .................................32
ConTrIbuTorS TueSday oral SeSSIonS .................................38
Fluid Management Systems wedneSday oral SeSSIonS ............................44
IDEX Health & Science THurSday oral SeSSIonS ..............................50
Microliter Analytical Supplies
monday poSTerS ............................................56
New Objective, Inc.
TueSday poSTerS............................................85
Pall Laboratory
PerkinElmer wedneSday poSTerS .....................................115
Tandem Labs THurSday poSTerS .......................................143
Thermo Scientific Index of auTHorS ........................................171
Zef Scientific, Inc.
63ND ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 1
GGEENNEERRAALL IINNFFOORRMMAATTIIOONN
reGISTraTIon is open 10:00 am - 8:00 pm on Sunday and plenary SeSSIonS oral SeSSIonS are 8:30 - 10:30 am and 2:30 - 4:30 pm
7:30 am - 5:00 pm on Monday through Thursday. Monday through Thursday.
monday, 4:45 - 5:30 pm Level 1
aTTenTIon award leCTure Session A (MOA, TOA, WOA, ThOA) .......................Hall 5
underGraduaTe STudenTS and fIrST TIme (aT aSmS) Hall 5, level 1 Session B (MOB, TOB, WOB, ThOB) ........Room 130/132
GraduaTe STudenTS Session C (MOC, TOC, WOC, ThOC) .......Room 123/124
4:00 - 4:45 pm, Sunday, Ballroom 220/221 Session D (MOD, TOD, WOD, ThOD) .......Room 120/127
Plan Your Strategy: What to See and Do at ASMS Award for a Distinguished Session E (MOE, TOE, WOE, ThOE) ...................Theater
Contribution in Mass Spectrometry Session F (MOF, TOF, WOF, ThOF) ..................Room 106
SundAy tutoriAl SeSSion, 5:00 - 6:30 pM Level 2
Hall 5, level 1 Brian T. Chait Session G (MOG, TOG, WOG, ThOG) .Ballroom 222/224
The Rockefeller University Session H (MOH, TOH, WOH, ThOH) ..Ballroom 220/221
oral preSenTaTIonS are projected from ASMS computers
5:00 - 5:45 pm
running Microsoft Office 2010. Speakers are required to use the
Statistical Experimental Design:
ASMS computers for their presentations.
The Building Blocks of a Good TueSday, 4:45 - 5:30 pm
Experiment award leCTure
SpeakerS must load presentations at least one day prior to
Hall 5, level 1
their talks. The speaker room is 116, level 1 between Hall 4
Ann L. Oberg
and 5. The room is open with a technician according to this
Mayo Clinic
schedule:
Biemann Medal
Sunday: 10:00 am - 8:00 pm
Monday through Thursday: 7:30 am - 2:00 pm
Michael J. MacCoss
University of Washington
poSTerS and exHIbIT booTHS are in the Poster/Exhibit Hall.
5:45 - 6:30 pm
The Hall is open:
Metabolite Profiling at the ‘Omic’
Sunday Reception ....................7:45 pm - 9:00 pm
Scale: Untargeted Does not Mean
Monday - Wednesday ..............7:30 am - 8:00 pm
Unplanned
Thursday ..................................7:30 am - 3:00 pm
THurSday, 4:45 - 5:30 pm
Gary Patti plenary leCTure
poSTer SeT-up is 7:30 am on the day scheduled. Refer
Washington University, St Louis Hall 5, level 1
to the poster numbers in this final program for board
assignments. A counter for poster supplies is near the main
The Evolution of Modern
entrance to the Hall.
Neurosurgery: A History of Trial and
SundAy ConferenCe opening, 6:45 - 7:45 pM Error, Success and Failure poSTer SeSSIonS are 10:30 am - 2:30 pm, Monday through
Hall 5, level 1 level Thursday.
G. Michael Lemole, Jr.
The University of Arizona College of
poSTer auTHorS must be present at posters on scheduled
Medicine
Welcome days at these times.
Vicki H. Wysocki 10:30 am - 1:00 pm ..........Odd-numbered posters
The Ohio State University don’T mISS 12:00 - 2:30 pm ...............Even-numbered posters
ASMS Vice President for Programs Presenters who must leave a poster unattended should post a
• ASMS Meeting, WedneSdAy, 4:45 - 5:30 pM return time. Presenters should wear “Poster Presenter” badges
Ballroom 222/224, level 2
which are available at the poster supply counter.
Enjoy a beverage while you applaud awards, hear about
new initiatives, and more! Posters should not be removed before 7:30 pm on Monday,
Tuesday and Wednesday. Thursday posters should be
• CloSing event, thurSdAy, 6:30 - 9:00 pM removed at 2:30 pm.
The Human Gut Microbiome and
City Museum
Healthy Growth Let’s celebrate! Your adventure lunCH ConCeSSIonS in the Poster/Exhibit hall offer a variety
begins with a maze of turrets of options to dine and network while taking a break from
Jeffrey L. Gordon
and open “tunnels” that lead posters. Concessions are open 11:00 am - 2:00 pm, Monday
Washington University, St. Louis School
to views of fantastic structures through Thursday.
of Medicine
and sculptures. Try your skills of
balance and courage, through exHIbITorS must staff exhibit booths as follows:
caves and impossible slides. End Sunday Reception ....................7:45 pm - 9:00 pm
SundAy WelCoMe reCeption, 7:45 - 9:00 pM
with a surprise “artist” and St. Monday - Thursday ................10:30 am - 2:30 pm
Poster/Exhibit Hall. Conference name badge is required.
Louis buffet. Buses will depart
from the convention center,
Exhibit Hall BC, Exhibit level
Washington Avenue entrance.
Ticket is required, $30.
PAGE 2 63ND ASMS CONFERENCE ON MASS SPECTROMETRY
GENERAL INFORMATION
oral SeSSIonS are 8:30 - 10:30 am and 2:30 - 4:30 pm workSHopS are 5:45 - 7:00 pm on Monday, Tuesday, and
Monday through Thursday. Wednesday. Light refreshments are provided in the pre-function
Level 1 areas on level 1 and outside ballroom on level 2.
Session A (MOA, TOA, WOA, ThOA) .......................Hall 5
Session B (MOB, TOB, WOB, ThOB) ........Room 130/132 dInner BreAk, 7:00 - 8:00 pM is time for a breath of fresh
Session C (MOC, TOC, WOC, ThOC) .......Room 123/124 air before the opening of hospitality suites at 8:00 pm.
Session D (MOD, TOD, WOD, ThOD) .......Room 120/127
Session E (MOE, TOE, WOE, ThOE) ...................Theater SpeCIal proGram for underGraduaTe STudenTS
Session F (MOF, TOF, WOF, ThOF). .................Room 106 • Sunday, 7:30 - 9:00 pm, Poster competition, Poster/
Level 2 Exhibit Hall
Session G (MOG, TOG, WOG, ThOG) .Ballroom 222/224 • Monday, 11:30 am - 1:00 pm, Meet the Experts. lunch
Session H (MOH, TOH, WOH, ThOH) ..Ballroom 220/221 tables reserved for undergraduate students in the Poster/
Exhibit Hall, Free vouchers for lunch will be provided at
oral preSenTaTIonS are projected from ASMS computers the tables. Arrive promptly at 11:30 am to obtain your
running Microsoft Office 2010. Speakers are required to use the voucher.
ASMS computers for their presentations. • Wednesday, 5:45 - 7:00 pm, Workshop: Getting
the Most out of Undergraduate Research in Mass
SpeakerS must load presentations at least one day prior to Spectrometry, Room 230
their talks. The speaker room is 116, level 1 between Hall 4
and 5. The room is open with a technician according to this free wIfI aCCeSS is provided in the Poster/Exhibit Hall.
schedule: Computers are provided at stations throughout the convention
Sunday: 10:00 am - 8:00 pm center.
Monday through Thursday: 7:30 am - 2:00 pm
ConferenCe proCeedInGS will be published online. Visit
poSTerS and exHIbIT booTHS are in the Poster/Exhibit Hall. www.asms.org after July 6 to view or download the Proceedings.
The Hall is open: Submission to the Proceedings does not constitute publication
Sunday Reception ....................7:45 pm - 9:00 pm and does not jeopardize the rights of authors to publish contents
Monday - Wednesday ..............7:30 am - 8:00 pm of their submissions. Speaker web casting slides will be
Thursday ..................................7:30 am - 3:00 pm printed to PDF and used for speakers who fail to submit.
poSTer SeT-up is 7:30 am on the day scheduled. Refer web CaSTInG includes tutorial lectures, plenary lectures,
to the poster numbers in this final program for board and oral sessions. Web casting will be available to conference
assignments. A counter for poster supplies is near the main attendees for three months after the conference. ASMS does
entrance to the Hall. not retain rights to material included in web castings. To access
the presentations, go to www.asms.org and log in. After login,
poSTer SeSSIonS are 10:30 am - 2:30 pm, Monday through go to annual conference page and select “web casting.” Web
Thursday. casting button is visible only to conference registrants.
poSTer auTHorS must be present at posters on scheduled CorporaTe HoSpITalITy SuITeS may be open 8:00 - 11:00
days at these times. pm, Monday through Wednesday. Suites are located in the
10:30 am - 1:00 pm ..........Odd-numbered posters Renaissance Grand Hotel.
12:00 - 2:30 pm ...............Even-numbered posters
Presenters who must leave a poster unattended should post a Career CenTer is located near the Washington Avenue
return time. Presenters should wear “Poster Presenter” badges entrance. The Career Center is open to all conference
which are available at the poster supply counter. attendees. Applicants and employers must enter resumes and
employment opportunities online. There are computers in the
Posters should not be removed before 7:30 pm on Monday, center for searching the database of candidates and positions.
Tuesday and Wednesday. Thursday posters should be Interview rooms must be reserved one day in advance.
removed at 2:30 pm. Sunday ...........................................7:45 - 9:00 pm
Monday – Wednesday ..............7:30 am - 5:00 pm
lunCH ConCeSSIonS in the Poster/Exhibit hall offer a variety Thursday ..................................7:30 am - 2:30 pm
of options to dine and network while taking a break from
posters. Concessions are open 11:00 am - 2:00 pm, Monday GueST reGISTraTIon ($10) includes designated name badge
through Thursday. and entrance to the Sunday evening reception. The badge does
not gain entrance to oral sessions or the Poster/Exhibit Hall.
exHIbITorS must staff exhibit booths as follows:
Sunday Reception ....................7:45 pm - 9:00 pm ConCIerGe deSk in the conference registration area offers
Monday - Thursday ................10:30 am - 2:30 pm information on transportation, attractions and restaurants.
63ND ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 3
GGEENNEERRAAL LIN INFFOORRMMAATTIOIONN
CorporaTe breakfaST SemInarS are hosted by some CorporaTe medIa evenTS are for members of the press
Corporate Members. Breakfast seminars are located on level and financial institutions. All will be held in the Renaissance
2 of the convention center and seats must be reserved in Grand Hotel.
advance. Please reserve at company exhibit booths.
Renaissance Hotel
Company Monday
MONDAY Location
Shimadzu 8:00-9:00 am Majestic F-H
Convention
Company
Center Room Bruker 9:30-10:30 am Majestic A-C
SCIEX 11:00 -12:00 pm Majestic D
Advanced Chemistry Development (ACD) Room 242
Agilent Technologies 1:30-2:30 pm Landmark 1-3
Agilent Technologies Room 276
Thermo Scientific 3:00-4:00 pm Landmark 4-7
Bruker Daltonics Room 263/264
Waters Corporation 4:30-5:30 pm Majestic E
LECO Room 241
SCIEX Room 265/266
SCIEX Room 275
ConferenCe reGulaTIonS
Shimadzu Room 274
• Name badge is required for all conference sessions,
Thermo Scientific (in Renaissance Hotel) Landmark 4-7
including the Poster/Exhibit Hall and the employment
Waters Room 230
center.
Waters Room 231
TUESDAY • No smoking is permitted in the convention center.
Convention
Company • Cell phones must be turned off in oral sessions.
Center Room
Agilent Technologies Room 276 • No photography or recording is allowed in oral sessions or
Biotage Room 231 in the poster/exhibit Hall.
Bruker Daltonics Room 263/264
• Material presented or displayed at the ASMS Conference,
EMD Millipore Room 240
including but not limited to orals, posters, workshops, exhibit
GL Sciences Room 265/266 booths and hospitality suites, is the intellectual property of
LECO Room 241 the presenter and may not be recorded, photographed,
New Objective Room 242 quoted, disseminated or transmitted by summary in any
form without the express written authority of the author of
Phenomenex Room 230
the material presented. Such materials that are published
Promega Room 261/262
in print or online must contain appropriate credits for all
Prosolia Room 232 quotations and photographs.
SCIEX Room 275
SCIEX (in Renaissance Hotel) Majestic D • The placement of advertising in the meeting area is
prohibited. There are poster boards and tables in the
Shimadzu Room 274
Poster/Exhibit Hall for approved announcements. No signs
Thermo Scientifc (in Renaissance Hotel) Landmark 4-7
on easels are permitted.
Waters Room 260/267
WEDNESDAY • Hardware, accessories or any items for sale may be
displayed only in corporate exhibit booths and hospitality
Convention
Company suites.
Center Room
Agilent Technologies Room 276 • No organized activities (even off-site) other than those
Bruker Daltonics Room 263/264 approved by ASMS are allowed during the conference
week (5:00 pm on Sunday through 6:00 pm on Thursday).
LECO Room 241
New Objective Room 242 • Corporate or institutional logos on slides or posters may
Promega Room 261/262 appear only one time in the presentation.
SCIEX Room 265/266
SCIEX Room 275
Shimadzu Room 274
Thermo Scientifc (in Renaissance Hotel) Landmark 4-7
Waters Room 230
Waters Room 231
THURSDAY
Convention
Company
Center Room
Shimadzu Room 274
Thermo Scientific Room 276
PAGE 4 63RD ASMS CONFERENCE ON MASS SPECTROMETRY
HOTELS
ConferenCe Hotels
Hotel Telephone Hotel Telephone
*Crowne Plaza Downtown 314-621-8200 Holiday Inn (formerly Ramada
314-421-5974
Plaza
*Drury Plaza at the Arch 314-231-3003
*Hyatt Regency 314 655 1234
Drury Inn & Suites Conv Ctr 314-231-8100
Magnolia 314-436-9000
Embassy Suites 314-269-5900
*Union Station St. Louis - A
314-621-5262
*Hampton Inn Gateway Arch 314-621-7900 Doubletree by Hilton Hotel
*Hilton Ballpark 314-421-1776 Renaissance Grand 314-621-9600
*Hilton Downtown 314-436-0002 *Shuttle service to/from the convention center and
hospitality suites will be provided from these hotels.
63RD ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5
ASGMESN BEROAALR DIN OFOF RDMIRAETCITOONRS
ConGraTulaTIonS
to these members who were elected to the ASMS Board
President
Jenny Brodbelt
Vice President for Arrangements
University of Texas
Austin, TX
Past President
Susan T. Weintraub
University of Texas Health Science Center
San Antonio, TX
Jack Henion
Advion, Quintiles and Cornell University
Vice President for Programs Ithaca, NY
Vicki H. Wysocki
Ohio State University Secretary
Columbus, OH
Vice President for Arrangements
Gary Valaskovic
New Objective, Inc
Woburn, MA
Yu Xia
Purdue University
Treasurer
West Lafayette, IN
Patrick R. Griffin
Scripps Research Institute
Member at Large for Publications
Jupiter, Florida
Secretary
Rebecca A. Jockusch
University of Toronto
Toronto, Canada
Facundo Fernandez
Georgia Institute of Technology
Member at Large for Education
Atlanta, GA
Igor Kaltashov
University of Massachusetts
Amherst, MA
STaff
Judith A. Sjoberg, Executive Director
Jennifer Watson
Member at Large for Publications
Cindi Pettit, Miquela Sena
David C. Muddiman
Marin Walker, Brent Watson
North Carolina State University
Raleigh, NC
Member at Large for Digital
Communications
Brian Searle
University of Washington
Seattle, WA
PAGE 6 63RD ASMS CONFERENCE ON MASS SPECTROMETRY
ASMS INTEREST GROUPS AND COMMITTEES
InTereST Group CoordInaTorS CommITTeeS
Analytical Laboratory Brett Phinney Asilomar Sharon Pitteri, Chair
Managers Chris Colangelo Conference Hao Chen
Bioinformatics for MS Sangtae Kim (ACMS) Julian Ryan
David Tabb Susan Weintraub
Biotherapeutics Alain Balland
Corporate Gary Valaskovic, Chair
Jason Hogan
Liaison Susan Weintraub
Damian Houde
Karen Anspach, Phenomenex
Clinical Chemistry Brett Holmquist
Johnny Cardenas, SCIEX
Brian Rappold
Lindsay Farnum, Agilent
Data Independent Yishai Levin Lance Nicolaysen, Waters
Acquisition Jarrett Egertson Qihui Ni, EMD Millipore
DNA/RNA Balasubrahmanyam Addepalli Bobbie Jo Seyler, Sigma Aldrich
Michael McGinley
Digital Bian Searle, Chair
Drug Metabolism & Kevin Bateman
Communications Ashley Gucinski
Pharmacokinetics Mustafa Varoglu
Bruce Pascal
Energy, Petroleum & Patrick Hatcher Brett Phinney
Biofuels Lateefah Stanford
Dasari Surendra
Environmental Marc Engel Susan Van Riper
Applications Chris Gill
Exposomics Anthony Macherone Education Igor Kaltashov, Chair
Skip Kingston Erin Carlson
Damian Houde
Flavor, Fragrance and Timothy Croley
Darin Smith
Foodstuff Walter Hammock
Elizabeth Stemler
Forensics & Glen Jackson
Homeland Security Guido Verbeck Nominating Barbara Larsen, Chair
FTMS Nathan Kaiser Hilkka Kenttamaa
Don Smith Michael Easterling
Lars Konermann
Fundamentals Alessandra Ferzoco
Jos Oomens David Tabb
H/D Exchange, Covalent Joshua Sharp
Publications David Muddiman, Chair
Labeling & Cross Linking David Weis
Michelle Cilia
Imaging MS Vilmos Kertesz Leslie Hicks
Zoltan Takats Richard Perry
Ion Mobility MS Erin Baker Jessica Prenni
Stephen Valentine Michael Gross (ex officio)
Ion Trap MS Daniel E. Austin
Sanibel JC Poutsma, Chair
Lipids & Lipodomics Stephen Blanksby
Conference Erin Baker
LC/MS Related Topics Michael Bereman Patrick Griffin
Helene Cardasis Fanyu Meng
Metabolomics Andrew Patterson
Sunia Trauger arCHIvIST
Metal Ion Coordination Benjamin Bythell Michael Grayson
Chemistry Alex Shvartsburg
Pharmaceuticals Christine Gu
Shawna Hengel
Photoionization MS Jack Syage
Ralf Zimmerman
Polymeric Materials Stephen Rumbelow
Gyorgy Vas
Regulated Bioanalysis Jian Wang
Undergraduate Elaine Marzluff
Research in MS J.C. Poutsma
Young Mass Olga Friese
Spectrometrists Kristin Wildsmith
63RD ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7
GENASEMRASL A IWNFAORRDMSATION
AwArd for A distinguished Contribution in MAss speCtroMetry
2015 reCipient: Brian t. CHait
award leCture: 4:45 pm, monday, Hall 5, level 1
Dr. Brian T. Chait is awarded the 2015 ASMS Award for a Distinguished Contribution in Mass
Spectrometry for the recognition and demonstration of the link between protein structure and
conformation and electrospray ionization mass spectra. His discovery that a protein’s solution
phase conformation impacts its electrospray ionization mass spectrometry (ESI-MS) charge
state distribution (CSD) blasted away the barriers isolating mass spectrometry from its ability to
probe higher order macromolecular structures and fostered a continuing deluge of applications
of MS to noncovalent assemblies, hydrogen/deuterium exchange, probes of gas-phase protein
structure, and ultimately “native mass spectrometry.”
Today, interpreting ESI-MS and MS/MS data for proteins examined from native solutions often
begins from NMR or crystal structures, based on assumptions that the gas-phase structure will
not be too distant. But 24 years ago there was no expectation that relationships from higher
order solution structure could be retained in the gas phase and any such assumption would have
been foolhardy. The Chait laboratory opened the world to this possibility, first by demonstrating
that electrosprayed cytochrome c molecules assumed about twice as much charge when
sprayed from pH 2.6 than from pH 5.2 HO (J. Am. Chem. Soc. 112, 9012 (1990)), by probing conformational changes in proteins
2
via hydrogen/deuterium exchange (Rapid Commun. Mass Spectrom. 5, 214 (1991)), and by monitoring solution-phase thermal
denaturation processes by ESI-MS (Anal. Chem. 65, 1, (1993)).
Dr. Chait’s achievement must be viewed from the perspective of mass spectrometry in 1990 when few of us were capable of
spraying 100% aqueous solutions, or did we see a need for it. For some of us an organic sheath solvent (or make-up flow) reduced
surface tension enough to complete our analyses; others simply added methanol directly. However, Chowdhury and Chait (Anal.
Chem. 63, 1660 (1991)) demonstrated that electropolished needles could electrospray water at voltages sufficiently below those
inducing dielectric breakdown. That ability to electrospray 100% HO was key to observing the charge state distribution differences
2
associated with natively folded proteins. Equally important was Dr. Chait’s ability to rationalize and prove that the source of the
observed CSD difference had to be solution-phase structure.
We know so little about electrospray ionization today; we knew even less 25 years ago, yet the ideas that Dr. Chait precisely
articulated about the electrospray CSD/conformation relationship were a turning point for biological mass spectrometry.
Dr. Brian T. Chait is the Head of the Laboratory of Mass Spectrometry and Gaseous Ion Chemistry and a Camille and Henry
Dreyfus Professor at The Rockefeller University, New York, NY.
RON A. HITES AWARD outstanding researCH puBliCation in Jasms
award presentation: asms meeting, 4:45 pm, wednesday, Ballroom 222/224
The Ron Hites Award recognizes an outstanding publication of original research, based on a paper’s
innovative aspects, technical and presentation quality, likely stimulation of future research and impact on
future applications. The award is named to honor Professor Ron Hites of Indiana University, who led
the creation of JASMS in 1988 while president of ASMS. The award includes $2,000 and a certificate for
each author.
The 2015 award recognizes John
Klassen, University of Alberta, and, co-
authors Lan Liu, Alyson Baergen, Klaus
Michelsen, Elena N. Kitova, and Paul
D. Schnier; for their paper Energetics
of Intermolecular Hydrogen Bonds in a
Hydrophobic Cavity: JASMS, 2014, 25,
742-750.
Left to right: Lan Liu, Elena Kitova,
and John Klassen
PAGE 8 63RD ASMS CONFERENCE ON MASS SPECTROMETRY
ASMS AWARDS
bIemann medal
2015 reCipient: miCHael J. maCCoss
award leCture: 4:45 pm, tuesday, Hall 5, level 1
Dr. Michael J. MacCoss has made a number of contributions of serious and long lasting impact
to the field of proteomics. Chief among these is software development that has greatly facilitated
proteomics. Dr. MacCoss’ philosophy on making software freely available and continually supporting
this software so that it enables others has greatly benefitted the proteomic sciences.
Bioinformatics tools developed by the MacCoss laboratory facilitate many different aspects of mass
spectrometry data analysis. This includes tools for liquid chromatography mass spectrometry (LC-
MS) feature finding, spectrum library searching, peak detection, post-processors for peptide database
searching, and more. An important early contribution from his lab, the Percolator algorithm, improved
peptide identifications from proteomic analyses through semi-supervised machine learning (Käll et
al. “Semi-supervised learning for peptide identification from shotgun proteomics datasets,” Nature
Methods, 2007). Percolator became widely adopted partially because of its use of a liberal open
source license that encouraged companies to build on Percolator and incorporate into commercial
packages (e.g. Mascot and Proteome Discoverer). Another high-impact contribution from the
MacCoss laboratory is the development and continued support of an integrated set of software
tools called Skyline (MacLean et al. “Skyline: an open source document editor for creating and analyzing targeted proteomics
experiments” Bioinformatics, 2010; available from http://skyline.maccosslab.org). Critically, Skyline is a vendor-neutral toolset,
thus enabling methods to be easily transferred and tested across labs, even those that utilize different instrument platforms.
Dr. MacCoss has also substantially advanced the new area of data-independent MS analyses. His key contribution in this area
has been to develop a multiplexed strategy to better isolate noise and improve signal detection and therefore sensitivity through
observational coherence (Egertson et al., Nature Methods 2013).
One of the most recent projects championed by Dr. MacCoss is a nonprofit to provide a cost effective mechanism for labs to
backup, share, visualize, and analyze data on the cloud called The Chorus Project (http://chorusproject.org). They are working
with developers in academic labs and companies to offer tools to our community that can process mass spectrometry data stored
within Chorus. The hope is to provide a platform where all labs have access to the latest analysis tools and published data can
be easily reanalyzed.
Dr. MacCoss is professor in the Department of Genome Sciences, University of Washington, Seattle.
2015 researCH awards
award presentation: 4:45 pm, tuesday, Hall 5
The Research Awards are fully funded by Thermo Scientific and Waters Corporation in the amount of $35,000 each.
Sponsored by Sponsored by
tHermo sCientifiC waters Corporation
Michael Bereman Alexander Ivanov
North Carolina State University Northeastern University
63RD ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9
GENAESRMASL AINWFAORRDMSATION
2015 POSTDOCTORAL AWARDS
award presentation: asms meeting, 4:45 pm, wednesday, Ballroom 222/224
Three awards in the amount of $10,000 each are intended to promote the professional career development of postdoctoral
fellows in the field of mass spectrometry. Activities funded by these awards include conference and workshop attendance, travel
to other mass spectrometry laboratories, purchase of books and/or software. The awards are open to ASMS members who are
postdoctoral fellows within three years of completing a Ph.D. or equivalent degree. Applicants must be currently appointed as a
postdoctoral fellow in North America (e.g., in academia, industry, a government or national laboratory or at a research institute).
Details and an application are posted to asms.org.
Martin Paine Valentina Pirro Gloria Sheynkman
Georgia Institute of Technology Purdue University Harvard Medical School
STUDENT AWARDS
award presentation: asms meeting, 4:45 pm, wednesday, Ballroom 222/224
2015 inaugurates two student conference travel awards. There are seven awards of $1,000 for graduate students and ten awards
of $500 for undergraduates. Applications and details for these awards are posted to asms.org. The deadline for submission is
January 15.
GraduaTe STudenT awardS underGraduaTe STudenT awardS
Benjamin Diner Quintin Ferraris
Princeton University Kean University
Albert Konijnenberg Joshua Fischer
University of Antwerp Wayne State University
Xin Liu James Keating
University of Notre Dame University of Michigan
Mandy Phelps James Matilla
University of North Texas James Madison University
Nicholas Riley Danielle McDougall
University of Wisconsin-Madison University of Florida
Vincent Sica Haley Miller
University of North Carolina-Greensboro Bowdoin College
Chih-Chiang Tsou Sydney Morris
University of Michigan George Washington University
Alexandra Plaviak
Duquesne University
Cheylene Tanimoto
Stanford University
Nick van Huizen
Erasmus MC
PAGE 10 63RD ASMS CONFERENCE ON MASS SPECTROMETRY