IFMBE Proceedings Volume 37 Series Editor: R. Magjarevic The International Federation for Medical and Biological Engineering, IFMBE, is a federation of national and transnational organizations representing internationally the interests of medical and biological engineering and sciences. The IFMBE is a non-profit organization fostering the creation, dissemi- nation and application of medical and biological engineering knowledge and the management of technology for improved health and quality of life. Its activities include participation in the formulation of public policy and the dissemination of information through publications and forums. Within the field of medical, clinical, and biological engineering, IFMBE’s aims are to encourage research and the application of knowledge, and to disseminate informa- tion and promote collaboration. The objectives of the IFMBE are scientific, technological, literary, and educational. The IFMBE is a WHO accredited NGO covering the full range of biomedical and clinical engineering, healthcare, healthcare technology and manage- ment. It is representing through its 60 member societies some 120.000 professionals involved in the various issues of improved health and health care delivery. IFMBE Officers President: Herbert Voigt, Vice-President: Ratko Magjarevic, Past-President: Makoto Kikuchi Treasurer: Shankar M. Krishnan, Secretary-General: James Goh http://www.ifmbe.org Previous Editions: IFMBE Proceedings, “5th European Conference of the International Federation for Medical and Biological Engineering”, Vol. 37, 2011, Budapest, Hungary, CD IFMBE Proceedings MEDITECH 2011, “International Conference on Advancements of Medicine and Health Care through Technology”, Vol. 36, 2011, Cluj-Napoca, Romania, CD IFMBE Proceedings BIOMED 2011, “5th Kuala Lumpur International Conference on Biomedical Engineering 2011” Vol. 35, 2011, Kuala Lumpur, Malaysia, CD IFMBE Proceedings NBC 2011, “15th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics” Vol. 34, 2011, Aalborg, Denmark, CD IFMBE Proceedings CLAIB 2011, “V Latin American Congress on Biomedical Engineering CLAIB 2011” Vol. 33, 2011, Habana, Cuba, CD IFMBE Proceedings SBEC 2010, “26th Southern Biomedical Engineering Conference SBEC 2010 April 30 – May 2, 2010 College Park, Maryland, USA”, Vol. 32, 2010, Maryland, USA, CD IFMBE Proceedings WCB 2010, “6th World Congress of Biomechanics (WCB 2010)”, Vol. 31, 2010, Singapore, CD IFMBE Proceedings BIOMAG2010, “17th International Conference on Biomagnetism Advances in Biomagnetism – Biomag2010”, Vol. 28, 2010, Dubrovnik, Croatia, CD IFMBE Proceedings ICDBME 2010, “The Third International Conference on the Development of Biomedical Engineering in Vietnam”, Vol. 27, 2010, Ho Chi Minh City, Vietnam, CD IFMBE Proceedings MEDITECH 2009, “International Conference on Advancements of Medicine and Health Care through Technology”, Vol. 26, 2009, Cluj-Napoca, Romania, CD IFMBE Proceedings WC 2009, “World Congress on Medical Physics and Biomedical Engineering”, Vol. 25, 2009, Munich, Germany, CD IFMBE Proceedings SBEC 2009, “25th Southern Biomedical Engineering Conference 2009”, Vol. 24, 2009, Miami, FL, USA, CD IFMBE Proceedings ICBME 2008, “13th International Conference on Biomedical Engineering” Vol. 23, 2008, Singapore, CD IFMBE Proceedings ECIFMBE 2008 “4th European Conference of the International Federation for Medical and Biological Engineering”, Vol. 22, 2008, Antwerp, Belgium, CD IFMBE Proceedings BIOMED 2008 “4th Kuala Lumpur International Conference on Biomedical Engineering”, Vol. 21, 2008, Kuala Lumpur, Malaysia, CD IFMBE Proceedings Vol. 37 Ákos Jobbágy (Ed.) 5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary 123 Editor Prof. Ákos Jobbágy Postal address: 1521 Budapest, p.o.b. 91. Hungary Phone: (+36 1) 463 2572 (+36 1) 463 2057 (admin) Fax: (+36 1) 463 4112 e-mail: [email protected] ISSN 1680-0737 ISBN 978-3-642-23507-8 e-ISBN 978-3-642-23508-5 DOI 10.1007/978-3-642-23508-5 Library of Congress Control Number: Applied for © International Federation for Medical and Biological Engineering 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permis- sions for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The IFMBE Proceedings is an Official Publication of the International Federation for Medical and Biological Engineering (IFMBE) Typesetting & Cover Design: Scientific Publishing Services Pvt. Ltd., Chennai, India. Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com Foreword In many countries the expected lifetime has increased substantially. As a result, the conventional healthcare cannot be sus- tained. Patients need to be involved in their own diagnosis and therapy, and they have to get personalized treatment. The objective of the 5th European IFMBE Conference is to demonstrate that joint R & D activity of medical doctors and engineers greatly increases the effectiveness of healthcare. In the 21st century, engineers offer to medical doctors Cooperation for Effective Healthcare Medical technology has been rapidly developing through the past decades. Papers submitted from 61 countries focus on different special details of biomedical engineering and medical technology. 170 external reviewers helped the Scientific Program Committee to select 353 papers which are included in the proceedings together with 12 invited and 3 keynote papers. As a result of the global economic recession the conference could not attract many sponsors. Special thanks to those who volunteered for the success of this event: members of the International Advisory Committee, Scientific Program Committee and Local Organizing Committee, the external reviewers, the invited speakers. We hope the conference lives on: participants continue the scientific discussions they have been involved in the different sessions. Authors will be happy to see this proceedings and thus their papers included also in ISI Proceedings, Scopus and Inspec. Budapest is a real Central European capital where East meets West, North meets South. You are welcome to come again and have fruitful scientific discussions, and to continue cooperation within any special field of biomedical engineering! Prof. Ákos JOBBÁGY Conference Chair Organization Conference Chair: Prof. Ákos JOBBÁGY Committees Local Organizing Committee Ákos JOBBÁGY András MERSICH Zoltán BENYÓ Ferenc MOLNÁR Lajos BORBÁS Emil MONOS Péter CSORDÁS György NÁDASY László DÉZSI Csaba NAGY János GINSZTLER Balázs NEMES Péter HANÁK Zsuzsa PINTÉR Zoltán HANTOS Éva PINTYE Levente KOVÁCS International Advisory Committee Chair: Nándor RICHTER, Hungary Piotr AUGUSTYNIAK, Poland Jari HYTTINEN, Finland Metin AKAY, USA Antonio Fernando INFANTOSI, Brazil Arnold BACA, Austria Timo JÄMSÄ, Finland Joe BARBENEL, UK Tomaz JARM, Slovenia Zhivko BLIZNAKOV, Greece Dov JARON, USA Bálint BOGA, Hungary András JÁVOR, Hungary Said Jorge CALIL, Brazil Miklós KELLERMAYER Jr., Hungary Aurelio CAPPOZZO, Italy Thomas KENNER, Austria Sergio CERUTTI, Italy Sun I. KIM, Korea Walter CHANG, Taiwan Richard L.G. KIRSNER, Australia Hariton COSTIN, Romania Peter KNEPPO, Czech Republic Juri DEKHTYAR, Latvia Zoi KOLITSI, Greece Judit FIDY, Hungary Harald KORB, Germany Didier GEIGER, France Márta KURUTZ, Hungary James GOH, Singapore Igor LACKOVIĆ, Croatia Enrique J. GOMEZ, Spain Dávid LÉGRÁDY, Hungary Katalin HANGOS, Hungary Nigel LOVELL, Australia Osmo HÄNNINEN, Finland Nicos MAGLAVERAS, Greece Péter HARCOS, Hungary Jaakko MALMIVUO, Finland Hiie HINRIKUS, Estonia Alexander MARTYNENKO, Ukraine Ernst HOFER, Austria Vladimir MEDVED, Croatia Jiři HOLČIK, Czech Republic Kalju MEIGAS, Estonia Roman HOVORKA, UK Heidrun MOLLENKOPF, Germany VIII Organization Ralph MUELLER, Switzerland László SCULTÉTY, Hungary Attila NASZLADY, Hungary Mario Forjaz SECCA, Portugal Marc NYSSEN, Belgium Maria SIEBES, The Netherlands Åke ÖBERG, Sweden Leif SÖRNMO, Sweden Tadeusz PALKO, Poland Jos A.E. SPAAN, The Netherlands Constantinos PATTICHIS, Cyprus Selma SUPEK, Croatia Antonio PEDOTTI, Italy János SZTIPÁNOVITS, USA Ivo PROVAZNIK, Czech Republic Slavik TABAKOV, Bulgaria Günter RAU, Germany Milan TYSLER, Slovakia Laura ROA, Spain Herbert F. VOIGT, USA Wim L.C. RUTTEN, The Netherlands John WEBSTER, USA Mario SANSONE, Italy Jan WÓJCICKI, Poland Günter SCHREIER, Austria Scientific Program Committee Biomechanics, movement analysis Home health monitoring Rita STAGNI, Italy Per ASK, Sweden Imre BOJTÁR, Hungary Toshiyo TAMURA, Japan Didier GEIGER, France Tamás KOVÁCSHÁZY, Hungary Biomaterials Information and communication Timo JÄMSÄ, Finland Ron SUMMERS, UK Toh SIEW LOK, Singapore Stanko TONKOVIĆ, Croatia János GINSZTLER, Hungary György SURJÁN, Hungary Instrumentation and signal processing Biosensors Sergio CERUTTI, Italy Radu CIUPA, Romania Mart MIN, Estonia Gábor HARSÁNYI, Hungary István KOLLÁR, Hungary Cardiovascular system analysis Imaging and image processing Alan MURRAY, UK Jan CORNELIS, Belgium Olaf DÖSSEL, Germany Jiři HOZMAN, Czech Republic György KOZMANN, Hungary Gábor HORVÁTH, Hungary Clinical engineering Laboratory diagnostics Nicolas PALLIKARAKIS, Greece Michiel J. VELLEKOOP, Austria Heikki TERIÖ, Sweden Jens DUCRÉE, Ireland Said Jorge CALIL, Brazil Géza NAGY, Hungary Education Micro- and nanotechnology Shankhar MUTHUKRISHNAN, USA Carmelina RUGGIERO, Italy Göran SALERUD, Sweden József GYULAI, Hungary Liz TANNER, UK Knowledge based and expert systems Minimal-invasive technology Lenka LHOTSKA, Czech Republic Thomas SCHMITZ-RODE, Germany Katalin HANGOS, Hungary Jos VANDER SLOTEN, Belgium Werner HORN, Austria András KOMÓCSI, Hungary Organization IX Modeling and simulation Rehabilitation Damijan MIKLAVČIČ, Slovenia Zlatko MATJACIC, Slovenia J. Geoffrey CHASE, New Zealand Gábor FAZEKAS, Hungary Tadeusz DOBROWIECKI, Hungary Lorenzo CHIARI, Italy Cellular and tissue engineering Neuroengineering, neural systems Peter I. LELKES, USA Nitish THAKOR, USA Alicia EL HAJ, UK Wim L.C. RUTTEN, The Netherlands Judit OVÁDI, Hungary György DIBÓ, Hungary Telemedicine Special topics Marc NYSSEN, Belgium Joachim NAGEL, Germany Enrique J. GOMEZ, Spain Ratko MAGJAREVIĆ, Croatia István VASSÁNYI, Hungary Zoltán BENYÓ, Hungary Andrew TODD-POKROPEK, UK Table of Contents Papers Keynote Papers Regenerative Medicine: The Past, the Present, and the Future .............................. 1 Robert M. Nerem Cardiovascular Variability Signals: Assessmentof Autonomic Controlling Systems with Novel Application Tools............................................................................ 3 S. Cerutti Rethinking Health ICT Enabled Services to Empower People to Manage Their Health ...... 4 Niilo Saranummi Ethical Issues Facing the Medical and Biological Engineering Profession Herbert F. Voigt Invited Papers Validation of Motion Analysis Protocols: A Fundamental Issue for Clinical Application and Modeling .................................................................................... 7 R. Stagni, L. Tersi, A. Merlo, Z. Sawaha, S. Fantozzi Tight Glycemic Control in Intensive Care: From Engineering to Clinical Practice Change.... 11 J.G. Chase, A.J. Le Compte, A. Evans, L. Ward, J. Steel, C.S. Tan, C.G. Pretty, S. Penning, T. Desaive, G.M. Shaw Electrochemotherapy – An Efficient Electroporation-Based Local Tumor Treatment ......... 15 Damijan Miklavˇciˇc Approaches and Impacts of Replacement, Reconstruction, and Regeneration in Medical Applications ................................................................................. 19 G. Rau Modelling and Simulation in Digital Tomosynthesis.......................................... 23 N. Pallikarakis and K. Bliznakova Organ Printing: A Novel Tissue Engineering Paradigm ...................................... 27 F. Marga, K. Jakab, C. Khatiwala, B. Shephard, S. Dorfman, G. Forgacs Improved Prediction of Hip Fracture Risk ................................................... 31 T. J¨ams¨a and P. Pulkkinen Notable e-Health Developments ............................................................. 35 M. Nyssen, R. Buyl, F. Questier, F. Verbeke, K. Thomeer Integration of Measurement Devices Supporting Diabetic Patients into a Remote Care System ...................................................................................... 39 L. Celi´c, D. Trogrli´c, I. Paladin, M. Praˇsek, R. Magjarevi´c Cortical Neurodynamics Explored: The Signal Processing Challenges in BCI and B2B....... 43 C.J. James XII Table of Contents Smart Instrumentation for Minimally Invasive Surgery ...................................... 46 Nele Famaey, Mauro Sette, Bert Willaert, Jos Vander Sloten Regulatory T Cells and TH17 Effector Cells in Peri-silicone Capsular Fibrosis ............... 50 Georg Wick, Nadine Plank, Evelyn Rabensteiner, Dolores Wolfram Health and Wellbeing in the Changing Urban Environment: A Systems Analysis Approach Dov Jaron Merging Cardiac MRI and Electrophysiology of the Heart Olaf D¨ossel Papers Instrumentation and Signal Processing Evaluation of Two Radiochromic Films for HVL Measurement .............................. 53 T. Gotanda, T. Katsuda, R. Gotanda, A. Tabuchi, K. Yamamoto, T. Kuwano, H. Yatake, K. Kashiyama, K. Yabunaka, T. Akagawa, Y. Takeda Diagnostic Validity in Gastric Cancer Screening by Record Linkage with the Osaka Cancer Registry – On Film Reading of Radiographer and Radiologist– .............................. 57 K. Yamamoto, H. Yamazaki, C. Kuroda, T. Katsuda, T. Kuwano, M. Takeshita, K. Hayashida, M. Yoneda, M. Azuma Binary Particle Swarm Optimizationand F-Ratio for Selection of Features in the Recognition of Asphyxiated Infant Cry ................................................................... 61 A. Zabidi, W. Mansor, L.Y. Khuan, I.M. Yassin, R. Sahak Body Electrical Loss Analysis (BELA) – An Electromagnetic Method for the Assessment of Abdominal Visceral Fat Accumulation ....................................................... 66 K.H. Blomqvist, R.E. Sepponen, J. Lundbom, N. Lundbom Advantages of Energy-Binned Photon Counting Detector.................................... 70 K. Ogawa, T. Kobayashi, F. Kaibuki, T. Yamakawa, T. Nagano, D. Hashimoto, H. Nagaoka An Instrumentation Design for Microsignal Output from Piezoresistive Microcantilever Biosensor for Human Stress ................................................................. 74 Lee Yoot Khuan, Mohd Firdaus Abdullah, Mohd Ismarul A. Ismai1, Abdul Razak M.S. Hamid, Ilham Rustam, Maureen S.A. Bujang, Nina Korlina Madzhi, Anuar Ahmad Denoising Ultrasound RF Signals by Wavelet Cycle Spinning Shrinkage ..................... 78 J.L. San Emeterio, E. Pardo, M.A. Rodr´ıguez Optimal Setup of Algorithms and Methods for Evaluation of Endocardial Electrograms Fractionation Complexity in Human ......................................................... 82 V. Kremen Voice Disorder Detection on the Basis of Continuous Speech................................. 86 Vicsi Kla´ra, Imre Viktor, M´esza´ros Krisztina Time and Frequency Domains Analysis of Mechanomyographic Signal during the Application of Different FES Profiles..................................................................... 90 Eduardo M. Scheeren, Eddy Krueger, Guilherme N. Nogueira-Neto, Vera Lu´cia S.N. Button, Percy Nohama