29th International Conference on Antiviral Research (ICAR)

103 Pages·2016·5.39 MB·English

La Jolla, CA
April 17- 21
2016
hosted by the
INTERNATIONAL
SOCIETY FOR
ANTIVIRAL
RESEARCH
(ISAR)
Program and Abstracts
TABLE of
International
Conference on
Antiviral Research CONTENTS
(ICAR)
3
Daily Schedule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4
Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6
Networking . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
7
Schedule at a Glance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
12
Women in Science Career Development Award Winners . . . . .
13
Program Schedule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
37
Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
95
Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2
Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR)
DAILY
International
Conference on
Antiviral Research SCHEDULE
(ICAR)
Sunday, April 17, 2016
› Women in Science Roundtable Luncheon
› Drug Discovery & Development 101
› Welcome and Keynote Address
› Opening Reception
Monday, April 18, 2016
› Structural Biology Symposia
› Gertrude Elion Award Lecture
› Oral Sessions
› Poster Session 1
› New Member and First Time Attendee Networking Reception
Tuesday, April 19, 2016
› Antonin Holy Award Lecture
› Oral Sessions
› Shotgun Session 1
› Diagnostic Technologies Workshop
› Career and Networking Happy Hour
Wednesday, April 20, 2016
› William Prusoff Young Investigator Award Lecture
› DNA Virus Symposia
› Oral Sessions
› Shotgun Session 2
› Poster Session 2
› Closing Reception and Banquet
Thursday, April 21, 2016
› Clinical Session
› Oral Sessions
3
Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR)
International
Conference on ORGANIZATION
Antiviral Research
(ICAR)
International Society for Antiviral Research and
Twenty-Ninth International Conference on Antiviral Research
Officers
President
Robert Buckheit, Jr.
Frederick, MD, USA – 2018
President-Elect Past President
José Este Phillip Furman
Barcelona, Spain – 2020 St . Augustine, FL, USA – 2016
Treasurer Secretary
Brian Gowen Graciela Andrei
Logan, UT – 2017 Leuven, Belgium – 2015
Board of Directors
Andrea Brancale Jennifer Moffat William Delaney
Cardiff, UK – 2016 Syracuse, NY, USA – 2017 Foster City, CA, USA – 2016
Roger Ptak Rhonda Cardin Kathie Seley-Radtke
Frederick, MD, USA – 2015 Cincinnati, OH, USA – 2015 Baltimore, MD, USA – 2016
Conference Committee
Chair
Phil Furman
Graciela Andrei Rhonda Cardin Johan Neyts
Masanori Baba Jose Este Amy Patick
Andrea Brancale Brian Gowen Roger Ptak
Robert Buckheit, Jr. Kathie Seley-Radtke
The International Society For Antiviral Research (ISAR)
The Society was organized in 1987 as a non profit scientific organization for the purpose of advancing and disseminating
knowledge in all areas of antiviral research . To achieve this objective, the Society organizes an annual meeting . The Society
is now in its twenty ninth year of existence, and has approximately 550 members representing 30 countries . Membership
application forms will also be available at the Conference Registration desk, or from our website www.isar-icar.com .
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Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR)
CONTRIBUTORS
International to the
Conference on
29th International Conference
Antiviral Research
(ICAR)
on Antivral Research
Confirmed Sponsors as of April 1, 2016
Platinum
Gilead Sciences, Inc.
Foster City, CA, USA
Gold
Alios BioPharma Inc., GlaxoSmithKline, Inc.
part of the Janssen Pharmaceutical Companies Research Triangle Park, NC, USA
South San Francisco, CA, USA
Silver
AbbVie Inc. ImQuest BioSciences Inc. JCR Pharmaceutical Co., Ltd.
North Chicago, IL, USA Frederick, MD, USA Ashiya, Japan
Chimerix Inc. Southern Research Institute
Durham, NC, USA Birmingham, AL, USA
Bronze
ACS Infectious Diseases Elsevier B.V. Riboscience LLC
Washington, DC, USA Amsterdam, The Netherlands Sunnyvale, CA, USA
Antiva Biosciences Inc. Institute for Antiviral Research Toyama Chemical Co., Ltd.
South San Francisco, CA, USA Utah State University, Logan, UT, USA Tokyo, Japan
Center for Drug Design, Kineta Inc. XpressBio
University of Minnesota Seattle, WA, USA Frederick, MD, USA
Minneapolis, MN, USA
Medivir AB
Huddinge, Sweden
Personal Contribution: Phil Furman
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Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR)
International
Conference on NETWORKING
Antiviral Research
(ICAR)
Keynote Address
SUNDAY, APRIL 17, 2016
Decoding Viral Genomics in the Next Generation Era
Richard Scheuermann, Ph.D.
J. Craig Venter Instititute
La Jolla, CA
Ebola Virus: Past, Present, Future
Heinz Feldmann, M.D., Ph.D.
National Institute of Allergy and Infectious Diseases
Hamilton, Montana, USA
Networking Events
Women in Science Roundtable Luncheon New Member and First Time Attendee
Sunday, April 17, 2016 Networking Reception
11:30 AM – 2:00 PM Monday, April 18, 2016
FAIRWAY 1 6:30 PM – 7:30 PM
FAIRWAY 1
Opening Reception
Sunday, April 17, 2016 Career and Networking Happy Hour
6:00 PM – 8:00 PM Tuesday, April 19, 2016
GRANDE BALLROOM PRE-FUNCTION 5:00 PM – 6:30 PM
GRANDE BALLROOM PRE-FUNCTION
Conference Reception and Banquet
Wednesday, April 20, 2016
7:30 PM – 10:00 PM
GRANDE BALLROOM ABC
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Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR)
SCHEDULE
International
Conference on
Antiviral Research at a GLANCE
(ICAR)
Sunday, April 17, 2016
TIME EVENT LOCATION
11:00 AM – 5:00 PM Registration GRANDE BALLROOM
PRE-FUNCTION
11:30 AM – 2:00 PM Women In Science Roundtable Luncheon FAIRWAY 1
2:00 PM – 4:00 PM Drug Discovery & Development 101 GRANDE BALLROOM ABC
4:00 PM – 4:30 PM Coffee Break GRANDE BALLROOM
PRE-FUNCTION
4:30 PM – 6:00 PM Keynote Address GRANDE BALLROOM ABC
6:00 PM – 8:00 PM Opening Reception GRANDE BALLROOM
Light hors d’oeuvres served PRE-FUNCTION
Monday, April 18, 2016
TIME EVENT LOCATION
7:30 AM – 5:30 PM Registration GRANDE BALLROOM
PRE-FUNCTION
7:30 AM – 8:30 AM Continental Breakfast GRANDE BALLROOM
PRE-FUNCTION
8:30 AM – 12:00 PM Structural Biology Symposia GRANDE BALLROOM ABC
10:00 AM – 10:30 AM Coffee Break GRANDE BALLROOM
PRE-FUNCTION
12:00 PM – 1:30 PM Lunch On Your Own
1:30 PM – 2:10 PM Gertrude Elion Award Lecture GRANDE BALLROOM ABC
2:10 PM – 4:30 PM Oral Sessions – In Vitro Evaluation GRANDE BALLROOM ABC
and Drug Resistance
3:00 PM – 3:30 PM Coffee Break GRANDE BALLROOM
PRE-FUNCTION
4:30 PM – 6:30 PM Poster Session I GRANDE BALLROOM DE &
Light hors d’oeuvres served SCRIPPS 1/2
6:30 PM – 7:30 PM New Member and First Time FAIRWAY 1
Attendee Networking Reception
Light hors d’oeuvres served
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Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR)
SCHEDULE at a GLANCE
Tuesday, April 19, 2016
TIME EVENT LOCATION
7:30 AM – 4:00 PM Registration GRANDE BALLROOM
PRE-FUNCTION
7:30 AM – 8:30 AM Continental Breakfast GRANDE BALLROOM
PRE-FUNCTION
8:30 AM – 9:00 AM Antonin Holý Award Lecture GRANDE BALLROOM ABC
9:00 AM – 10:15 AM Oral Sessions – Medicinal Chemistry GRANDE BALLROOM ABC
10:15 AM – 10:45 AM Coffee Break GRANDE BALLROOM
PRE-FUNCTION
10:45 AM – 11:35 AM Oral Sessions – In Vitro Antiviral Activity GRANDE BALLROOM ABC
11:35 AM – 12:00 PM Shotgun Session 1 GRANDE BALLROOM ABC
12:00 PM – 1:30 PM Lunch On Your Own
1:30 PM – 1:45 PM International Society for GRANDE BALLROOM ABC
Antiviral Research Business Meeting
1:45 PM – 2:45 PM Zika Virus GRANDE BALLROOM ABC
2:45 PM – 4:45 PM Diagnostic Technologies Symposium GRANDE BALLROOM ABC
3:15 PM – 3:45 PM Coffee Break GRANDE BALLROOM
PRE-FUNCTION
6:30 PM – 8:00 PM Career and Networking Happy Hour GRANDE BALLROOM
Light hors d’oeuvres served PRE-FUNCTION
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Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR)
SCHEDULE at a GLANCE
Wednesday, April 20, 2016
TIME EVENT LOCATION
7:30 AM – 5:00 PM Registration GRANDE BALLROOM
PRE-FUNCTION
7:30 AM – 8:30 AM Continental Breakfast GRANDE BALLROOM
PRE-FUNCTION
8:30 AM – 9:00 AM William Prusoff Young Investigator Award GRANDE BALLROOM ABC
9:00 AM – 12:00 PM DNA Virus Symposia GRANDE BALLROOM ABC
9:50 AM – 10:20 AM Coffee Break GRANDE BALLROOM
PRE-FUNCTION
12:00 PM – 1:30 PM Lunch On Your Own
1:30 PM – 4:30 PM Oral Sessions – Mechanism of GRANDE BALLROOM ABC
Action Studies
2:50 PM – 3:20 PM Coffee Break GRANDE BALLROOM
PRE-FUNCTION
4:30 PM – 6:30 PM Poster Session 2 GRANDE BALLROOM DE &
Light hors d’oeuvres served SCRIPPS 1/2
7:00 PM – 7:30 PM Closing Reception GRANDE BALLROOM
Light hors d’oeuvres served PRE-FUNCTION
7:30 PM – 10:00 PM Closing Banquet GRANDE BALLROOM ABC
Dinner served
Thursday, April 21, 2016
TIME EVENT LOCATION
7:30 AM – 12:00 PM Registration GRANDE BALLROOM
PRE-FUNCTION
7:30 AM – 8:30 AM Continental Breakfast GRANDE BALLROOM
PRE-FUNCTION
8:30 AM – 10:00 AM Clinical Session GRANDE BALLROOM ABC
10:00 AM – 10:30 AM Coffee Break GRANDE BALLROOM
PRE-FUNCTION
10:30 AM – 11:40 AM Oral Sessions – Animal Models of Infection GRANDE BALLROOM ABC
11:40 AM – 12:00 PM Shotgun Session 2 GRANDE BALLROOM ABC
12:00 PM Conference Concludes
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Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR)
ICAR
Career and Networking Happy Hour
Please join us for an informal career discussion and networking at the 29th ICAR meeting.
This year we will again host an excellent group of moderators who are recognized experts
in various areas of antiviral research and have pursued successful career in academia,
government, or industry. As a part of the informal group discussion, the moderators will
be ready to share their experience, answer questions, and provide feedback about career
development. In addition, you will have opportunity to network with your colleagues and
make new contacts.
The event is open to all ICAR attendees. Please sign up during the ICAR conference at the
registration desk before 8:30 AM on Tuesday, April 19.
Tuesday
April 19, 2016
5:00 PM – 6:30 PM
ROOM:
GRANDE BALLROOM
PRE-FUNCTION