28th International Conference on Antiviral Research (ICAR) Program & Abstracts

176 Pages·2015·3.41 MB·English

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I C A R
Hosted by
ISAR
INTERNATIONAL SOCIETY
FOR ANTIVIRAL RESEARCH
Hosted by
ISAR
Program and Abstracts
INTERNATIONAL SOCIETY
FOR ANTIVIRAL RESEARCH
S A R TABLE of
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IFNOTRE RANNATTIVIOIRNAALL R SEOSECAIRETCYH CONTENTS
Daily Schedule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
Networking . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
Schedule at a Glance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
Women in Science Career Development Award Winners . . . . . . . . . . . 11
Program Schedule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Program and Abstracts of the 28th International Conference on Antiviral Research (ICAR) 2
S A R DAILY
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IFNOTRE RANNATTIVIOIRNAALL R SEOSECAIRETCYH SCHEDULE
MONDAY, MAY 11, 2015
› Women in Science Roundtable
› Drug Development 101 – Microbicide/PREP
› Welcome and Keynote Address
› Opening Reception
TUESDAY, MAY 12, 2015
› RNA Viruses Symposium
› Lunch (on your own)
› Gertrude Elion Award Lecture
› Oral Sessions – Drug Screening Technologies
› Oral Sessions – In Vitro Evaluation and Antiviral Resistance
› Poster Session I
› New Member and First Time Attendee Networking Event
WEDNESDAY, MAY 13, 2015
› Antonin Holý Award Lecture
› Oral Sessions – Antiviral Chemistry
› Shotgun Presentation I
› Career Networking and Discussion Luncheon
› Lunch (on your own)
THURSDAY, MAY 14, 2015
› William Prusoff Young Investigator Award Lecture
› Emerging Viruses Symposium
› Lunch (on your own)
› Oral Sessions – Targets and Mechanisms of Action
› Shotgun Presentations II
› Poster Session II
› Closing Reception/Banquet
FRIDAY, MAY 15, 2015
› HCV Plenary – Clinical Evaluation of Antiviral Therapies Animal Models of Infection
Program and Abstracts of the 28th International Conference on Antiviral Research (ICAR) 3
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IIFNOTRE RANNATTIVIOIRNAALL R SEOSECAIRETCYH ORGANIZATION
International Society for Antiviral Research and
Twenty-Eighth International Conference on Antiviral Research
OFFICERS
President
Robert Buckheit
Frederick, MD, USA – 2018
President-Elect Past President
José Este Phillip Furman
Barcelona, Spain – 2020 St . Augustine, FL, USA – 2016
Treasurer Secretary
Brian Gowen Graciela Andrei
Logan, UT – 2017 Leuven, Belgium – 2015
BOARD OF DIRECTORS
Andrea Brancale Jennifer Moffat William Delaney
Cardiff, UK – 2016 Syracuse, NY, USA – 2017 Foster City, CA, USA – 2016
Roger Ptak Rhonda Cardin Kathie Seley-Radtke
Frederick, MD, USA – 2015 Cincinnati, OH, USA – 2015 Baltimore, MD, USA – 2016
CONFERENCE COMMITTEE
Chair
Phillip Furman
Dale Barnard Johan Neyts Jose Este
Phil Furman Roger Ptak Jack Secrist
Amy Patick Masanori Baba Robert Buckheit
Graciela Andrei Rhonda Cardin
The International Society For Antiviral Research (ISAR)
The Society was organized in 1987 as a non‐profit scientific organization for the purpose of advancing and disseminating knowledge in all
areas of antiviral research . To achieve this objective, the Society organizes an annual meeting . The Society is now in its twenty eighth year
of existence, and has approximately 550 members representing 30 countries . Membership application forms will also be available at the
Conference Registration desk, or from our website www.isar-icar.com .
Program and Abstracts of the 28th International Conference on Antiviral Research (ICAR) 4
R CONTRIBUTORS
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IFNOTRE RANNATTIVIOIRNAALL R SEOSECAIRETCYH 28tho nIn AtenrtnivaitTriOao lnT HRaEle Cseoanrfcehrence

Confirmed Sponsors as of April 21, 2015
PLATINUM
Gilead Sciences, Inc.
Foster City, CA, USA
GOLD
Chimerix, Inc. GlaxoSmithKline, Inc.
Durham, NC, USA Research Triangle Park, NC, USA
SILVER
Alios Biopharma, Inc. JCR Pharmaceutical
South San Francisco, CA, USA Co., Ltd.
Ashiya, Japan
Biota Pharmaceuticals
Alpharetta, GA, USA Southern Research Institute
Birmingham, AL, USA
Elsevier B.V.
Amsterdam, The Netherlands
BRONZE
ACS Infectious Diseases Medivir AB
Washington, DC, USA Huddinge, Sweden
Bristol-Myers Squibb Novira Therapeutics, Inc.
Wallingford, CT, USA Radnor, PA, USA
Center for Drug Design PTC Therapeutics, Inc.
University of Minnesota, Minneapolis, MN, USA South Plainfield, NJ, USA
ImQuest BioSciences, Inc. Toyama Chemical Co.
Frederick, MD, USA Ltd ., Tokyo, Japan
Institute for Antiviral Research XpressBio
Utah State University, Logan, UT, USA Frederick, MD, USA
Program and Abstracts of the 28th International Conference on Antiviral Research (ICAR) 5
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IIFNOTRE RANNATTIVIOIRNAALL R SEOSECAIRETCYH NETWORKING
KEYNOTE ADDRESS
MAY 11
From the Elucidation of the HCV Life Cycle
to the Development of Highly EffectiveAntivirals
Raffaele De Francesco, Ph.D.
Istituto Nazionale Genetica Molecolare, Milano, Italy
Doctors Without Borders Perspective on Ebola .
Armand Sprecher, M.D. M.P.H.
Doctors Without Borders, Brussels, Belgium

MAY 15
Advances in HCV Therapies
Michael Manns, M.D.
NETWORKING EVENTS
Women in Science Roundtable* Career Networking
Monday, May 11, 2015 and Discussion Luncheon*
11:30 AM – 2:00 PM Wednesday, May 13, 2015
LOCATION: FARNESE 12:00 PM – 1:30 PM
LOCATION: TORLONIA
Opening Reception
Monday, May 11, 2015 Conference Banquet
6:30 PM – 8:30 PM Thursday, May 14, 2015
LOCATION: FARNESE AND ORSINI Reception 7:30 PM
Dinner 8:00 PM – 10:00 PM
New Member and First Time Attendee
LOCATION: FARNESE AND ORSINI
Networking Event
Tuesday, May 12, 2015
6:45 PM – 7:30 PM
LOCATION: ORSINI
*Space is limited and pre-registration is required.
Program and Abstracts of the 28th International Conference on Antiviral Research (ICAR) 6
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I S A SCHEDULE
IFNOTRE RANNATTIVIOIRNAALL R SEOSECAIRETCYH at a GLANCE
MONDAY, MAY 11, 2015
TIME EVENT LOCATION
11:00 AM – 5:30 PM Registration REGISTRATION FOYER
11:30 AM – 2:00 PM Women In Science Roundtable FARNESE
2:00 PM – 4:00 PM Drug Development 101 ESTENSI – MEDICI
4:15 PM – 6:15 PM Keynote Addresses ESTENSI – MEDICI
6:30 PM – 8:30 PM Opening Reception FARNESE AND ORSINI
Light hors d’oeuvres served
TUESDAY, MAY 12, 2015
TIME EVENT LOCATION
7:00 AM – 5:30 PM Registration REGISTRATION FOYER
8:30 AM – 12:00 PM RNA Viruses Symposium ESTENSI – MEDICI
12:00 PM – 1:30 PM Lunch On Your Own
1:30 PM – 2:30 PM Gertrude Elion Award Lecture ESTENSI – MEDICI
2:30 PM – 4:30 PM Oral Sessions – Drug Screening Techniques ESTENSI – MEDICI
and In Vitro Evaluation and Antiviral Resistance
4:30 PM – 6:30 PM Poster Session I FERNANDES
Light hors d’oeuvres served
6:45 PM – 7:30 PM New Member and First Time ORSINI
Attendee Networking Reception
Light hors d’oeuvres served
Program and Abstracts of the 28th International Conference on Antiviral Research (ICAR) 7
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SCHEDULE at a GLANCE IFNOTRE RANNATTIVIOIRNAALL R SEOSECAIRETCYH
WEDNESDAY, MAY 13, 2015
TIME EVENT LOCATION
7:30 AM – 12:00 PM Registration REGISTRATION FOYER
8:30 AM – 9:00 AM Antonin Holý Award Lecture ESTENSI – MEDICI
9:15 AM – 11:30 AM Antiviral Chemistry ESTENSI – MEDICI
11:30 AM – 12:00 PM Shotgun Presentation I ESTENSI – MEDICI
12:00 PM – 1:30 PM Career Networking and Discussion Luncheon TORLONIA
12:00 PM Networking Afternoon
THURSDAY, MAY 14, 2015
TIME EVENT LOCATION
7:30 AM – 5:30 PM Registration REGISTRATION FOYER
8:30 AM – 9:15 AM William Prusoff Young Investigator Award ESTENSI – MEDICI
9:15 AM – 12:00 PM Emerging Viruses Symposium ESTENSI – MEDICI
Sponsored by Antiviral Research
12:00 PM – 1:15 PM Lunch On Your Own
1:15 PM – 1:30 PM ISAR Business Meeting ESTENSI – MEDICI
1:30 PM – 3:30 PM Oral Sessions – Targets and Mechanism of Action ESTENSI – MEDICI
3:30 PM – 4:00 PM Shotgun Presentations II ESTENSI – MEDICI
4:00 PM – 6:00 PM Poster Session 2 FERNANDES
Light hors d’oeuvres served
7:30 PM – 8:00 PM Closing Reception FARNESE AND ORSINI
8:00 PM – 10:00 PM Closing Banquet FARNESE AND ORSINI
FRIDAY, MAY 15, 2015
TIME EVENT LOCATION
7:30 AM – 12:00 PM Registration REGISTRATION FOYER
8:30 AM – 10:00 AM Keynote Address ESTENSI – MEDICI
11:00 AM – 12:00 PM Oral Sessions – Animal Models ESTENSI – MEDICI
Program and Abstracts of the 28th International Conference on Antiviral Research (ICAR) 8
ICAR Career Networking and Discussion Luncheon
Wednesday, May 13, 2015 12:00 PM – 1:30 PM | ROOM: TORLONIA
Please join us for an informal career discussion and networking at the 28th ICAR meeting.
This year we will again host an excellent group of moderators who are recognized experts
in various areas of antiviral research and have pursued successful career in academia,
government, or industry. As a part of the informal group discussion, the moderators will
be ready to share their experience, answer questions, and provide feedback about career
development. In addition, you will have opportunity to network with your colleagues and
make new contacts.
The event is open to all ICAR attendees. Please sign up during the ICAR conference at the
registration desk before 10:30 AM on Tuesday, May 12.
Moderators
ACADEMIA SECTOR MODERATORS LARGE PHARMA SECTOR MODERATORS
• Jose Este (Irsicaixa, Spain) • Weidong Zhong (Novartis, USA)
• Piet Herdewijn (University of Leuven, Belgium) • Robert Jordan (Gilead, USA)
• Richard Mackman (Gilead, USA)
GOVERNMENT SECTOR MODERATORS
• Sina Bavari contacted (USAMRIID, USA) CONTRACT RESEARCH ORGANIZATIONS
• Ramya Natarajan, PhD (NIH, USA) (CRO) SECTOR MODERATORS
• J. Robert Bostwick (SRI, USA)
BIOTECH SECTOR MODERATORS • Eric Stavale (IBT, USA)
• Randall Lanier, PhD (Chimerix, USA)
• Sven Enterlein (IBT, USA)
Monday, May 11
11:30 – 2:00 pm
ROOM: FARNESE
PARCO DEI PRINCIPI HOTEL
Rome Italy
3rd Annual
Women in Science
Roundtable
This session is open to all ICAR attendees, both women and men, and will feature prominent
women scientists who will talk about the challenges they have faced and the lessons they
have learned while navigating the twists and turns of their personal career progression.
We invite you to come and hear their perspectives as well as network with other scientists
in the industry, government and academic sectors.
The following speakers are confirmed:
Professor Gabriella Campadelli-Fiume
Microbiology and Virology, University of Bologna,
Department of Experimental, Diagnostic and Specialty Medicine, Bologna, Italy
Professor Kathie Seley-Radtke
Chemistry and Biochemistry, University of Maryland, Baltimore County,
Baltimore, MD, USA
Professor Jennifer Moffat
Microbiology and Immunology, State University of New York (SUNY)
Upstate Medical University, Syracuse, NY, USA