2021 Updates in Therapeutics®: Pharmacotherapy Preparatory Review and Recertification Course

608 Pages·2021·17.01 MB·english

by  Board Certified Pharmacists and clinical experts

Pharmacotherapy

preparatory review and re cer tif ica tio n co urse
Vol 2 2021 ACCP UPDATES IN THERAPEUTICS ®
®
American College of Clinical Pharmacy
Updates in Therapeutics®:
Pharmacotherapy Preparatory Review
and Recertification Course
American College of Clinical Pharmacy
Updates in Therapeutics®:
Pharmacotherapy Preparatory Review
and Recertification Course
2021 Edition
Volume 2
Senior Director of Professional Development and Member Services: Nancy M. Perrin, M.A., CAE
Associate Director, Professional Development & Marketing: Joanna Gillette
Senior Project Manager: Hannah Keal
Senior Medical Editor: Kimma Sheldon-Old, Ph.D.
Cover Design: Dane Anderson; Layout: Steven M. Brooker
For order information or questions, contact:
American College of Clinical Pharmacy
13000 W. 87th St. Parkway
Lenexa, KS 66215-4530
Telephone: [phone]
Fax: [phone]
[email protected]
www.accp.com
Copyright © 2021 by the American College of Clinical Pharmacy. All rights reserved. This book is protected by copyright. No part of this
publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic or mechanical, including
photocopy, without prior written permission of the American College of Clinical Pharmacy.
To properly cite this book:
Author(s). Chapter name. In: Bondi DS, Bridgeman MM, Burke JM, et al., eds. Updates in Therapeutics®: Pharmacotherapy Preparatory Review
and Recertification Course, 2021 ed. Lenexa, KS: American College of Clinical Pharmacy, year:pages.
Note: The authors and publisher of the Pharmacotherapy Preparatory Review and Recertification Course recognize that the development of this
material offers many opportunities for error. Despite our very best efforts, some errors may persist into print. Drug dosage schedules are, we
believe, accurate and in accordance with current standards. Readers are advised, however, to check other published sources to be certain that
recommended dosages and contraindications are in agreement with those listed in this book. This is especially important in new, infrequently used,
or highly toxic drugs.
PRINT ISBN: 978-1-952291-19-7
EBOOK ISBN: 978-1-952291-20-3

Errata: When possible, corrections to this publication are included in the 2021 Pharmacotherapy Preparatory Review and Recertification Course
Errata, which will be available beginning May 17, 2021, at www.accp.com/media/ppc21/errata.pdf.
Continuing Pharmacy Education:
The American College of Clinical Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing
pharmacy education. The Universal Activity Numbers for the Pharmacotherapy Preparatory Review and Recertification Home Study Course,
2021 edition, are as follows: Pharmacokinetics: A Refresher, Men’s and Women’s Health, Pediatrics, and Policy, Practice,
and Regulatory Issues, Activity No. 0217-0000-21-094-H04-P, 5.0 contact hours; Biostatistics: A Refresher, Study Designs,
Chronic Care in Cardiology, and Acute Care in Cardiology, Activity No. 0217-9999-21-085-H04-P, 5.5 contact hours; Infec-
tious Diseases I, Infectious Diseases II, Neurology, General Psychiatry, and Fluids, Electrolytes, and Nutrition, Activity No.
0217-9999-21-086-H01-P, 5.75 contact hours; Critical Care, Anticoagulation, Endocrine and Metabolic Disorders, Oncology
Supportive Care, and Gastrointestinal Disorders, Activity No. 0217-9999-21-087-H01-P, 5.5 contact hours; Geriatrics, Nephrology, and Pulmo-
nary Disorders and Adult Immunizations, Activity No. 0217-9999-21-088-H04-P, 3.5 contact hours. All Pharmacotherapy Preparatory Review
and Recertification Course sessions are application-based activities.
To earn continuing pharmacy education credit for the home-study version of the 2021 Pharmacotherapy Preparatory Review and Recertification
Course, you must review all content and complete the attestation statements and course evaluations by May 17, 2024. Statements of continuing
pharmacy education credit will be available at CPE Monitor within 2–3 business days after completion of this activity.
Board Certified Pharmacotherapy Specialist (BCPS) Recertification Credit
The Pharmacotherapy Preparatory Review and Recertification Course is part of a Board of Pharmacy Specialties (BPS)-approved professional
development program for BCPS recertification credit. To be eligible to earn the 25.25 contact hours of pharmacotherapy recertification credit for the
Pharmacotherapy Preparatory Review and Recertification Course, you must purchase and successfully submit the completed web-based posttest(s)
by 11:59 p.m. (CDT) on May 17, 2022. To learn more about the Board of Pharmacy Specialties (BPS) specialty exams, please visit their website:
www.bpsweb.org.
_____________________________________________________________________________________________________________________
The American College of Clinical Pharmacy (ACCP) has compiled the materials in this course book for pharmacists to use in preparing for
the Board of Pharmacy Specialties (BPS) Pharmacotherapy Specialty certification examination. There is no intent or assurance that all of the
knowledge on the examination will be covered in the ACCP process. Although ACCP does use the BPS Content Outline in creating the material
for this course, ACCP does not know the specific content of any particular BPS examination. BPS guidelines prohibit any overlap of individuals
writing the examination and developing preparatory materials. To maintain its strict, independent standards for certification, BPS does NOT
endorse or provide review information, preparatory courses, or study guides for Board Certification Examinations.
Program Goals and Target Audience
Program Goals and Target Audience
The Updates in Therapeutics®: Pharmacotherapy Preparatory Review and Recertification Course is designed to help
pharmacists who are preparing for the Board of Pharmacy Specialties certification examination in Pharmacotherapy as
well as those seeking a general review and refresher on disease states and therapeutics. The program goals are as follows:
1. To present a high-quality, up-to-date overview of disease states and therapeutics;
2. To provide a framework to help attendees prepare for the specialty certification examination in pharmacotherapy; and
3. T o offer participants an effective learning experience using a case-based approach with a strong focus on the thought
processes needed to solve patient care problems in each therapeutic area.
ACCP Updates in Therapeutics® 2021: Pharmacotherapy Preparatory Review and Recertification Course
2-i
Faculty
Faculty
Deborah S. Bondi, Pharm.D., BCPS, BCPPS Leslie A. Hamilton, Pharm.D., FCCP, FCCM, BCPS,
Clinical Pharmacy Coordinator – Pediatrics BCCCP
Clinical Pharmacy Specialist – Neonatal Intensive Care Unit Associate Professor
University of Chicago Medicine, Comer Children’s Hospital University of Tennessee Health Science Center
Chicago, Illinois Department of Clinical Pharmacy and Translational Science;
Neurocritical Care Clinical Specialist
Mary M. Bridgeman, Pharm.D., BCPS, BCGP University of Tennessee Medical Center
Clinical Professor Knoxville, Tennessee
Ernest Mario School of Pharmacy
Rutgers University Brian K. Irons, Pharm.D., FCCP, BCACP
Piscataway, New Jersey Professor of Pharmacy Practice
Texas Tech University Health Sciences Center
John M. Burke, Pharm.D., FCCP, BCPS Jerry H. Hodge School of Pharmacy
Professor of Pharmacy Practice Lubbock, Texas
Associate Dean for Post-Graduate Education
St. Louis College of Pharmacy Ashley H. Meredith, Pharm.D., FCCP, BCACP, BCPS, CDE
St. Louis, Missouri Clinical Associate Professor
Purdue University College of Pharmacy;
Jacintha S. Cauffield, Pharm.D., BCPS, CDE, CRPS-A Clinical Pharmacy Specialist – Ambulatory Care
Associate Professor of Pharmacy Practice Eskenazi Health
The Lloyd L. Gregory School of Pharmacy Indianapolis, Indiana
Palm Beach Atlantic University
West Palm Beach, Florida Emily M. Scopelliti, Pharm.D., BCPS
Associate Professor – Department of Pharmacy Practice
Paul P. Dobesh, Pharm.D., FCCP, BCPS, BCCP Thomas Jefferson University
Professor of Pharmacy Practice and Science Philadelphia, Pennsylvania
University of Nebraska Medical Center College of Pharmacy
Omaha, Nebraska Curtis L. Smith, Pharm.D., FCCP, BCPS
Professor
Christopher T. Elder, Pharm.D., BCOP Ferris State University;
Assistant Professor of Pharmacy Practice Clinical Pharmacist
The Lloyd L. Gregory School of Pharmacy Sparrow Health System
Palm Beach Atlantic University Lansing, Michigan
West Palm Beach, Florida
Kevin M. Sowinski, Pharm.D., FCCP
Shannon W. Finks, Pharm.D., FCCP, BCPS, BCCP, Professor of Pharmacy Practice
AHSCP-CHC Purdue University College of Pharmacy;
Professor of Clinical Pharmacy and Translational Science Adjunct Professor of Medicine
University of Tennessee College of Pharmacy Indiana University School of Medicine
Memphis, Tennessee Indianapolis, Indiana
Caitlin M. Gibson, Pharm.D., BCPS, BCCP Dustin D. Spencer, Pharm.D., MBA, BCPS, BCCP
Associate Professor Clinical Director
Vice Chair in Pharmacotherapy Cardinal Health
University of North Texas System College of Pharmacy Martinsville, Indiana
Fort Worth, Texas
Timothy E. Welty, Pharm.D., M.A., FCCP, FAES
Professor of Pharmacy Practice
Drake University;
Pharmacotherapy Specialist
Unity Point Neurology
Des Moines, Iowa
ACCP Updates in Therapeutics® 2021: Pharmacotherapy Preparatory Review and Recertification Course
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Faculty
Sheila M. Wilhelm, Pharm.D., FCCP, BCPS
Clinical Professor
Wayne State University
Eugene Applebaum College of Pharmacy and Health
Sciences
Detroit, Michigan
Corey J. Witenko, Pharm.D., BCPS, BCCCP
Clinical Pharmacy Manager
Director of PGY1 Pharmacy Residency Program
New York-Presbyterian Hospital/Weill Cornell Medical
Center
New York, New York
ACCP Updates in Therapeutics® 2021: Pharmacotherapy Preparatory Review and Recertification Course
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Disclosures
Faculty Disclosures
Consultant/Member of Advisory Board: Paul Dobesh (Pfizer/BMS Alliance, Janssen), Christopher T. Elder
(BMS, GSK, AstraZeneca, Acceleron, Kyowa Kirin), Ashley H. Meredith (Birth Control Pharmacist, JACCP
Editorial Board), Timothy E. Welty (Council on Clinical Activities, American Epilepsy Society)
Speaker’s Bureau: Mary M. Bridgeman (AstraZeneca), Ashley H. Meredith (Surgent PharmCon)
Nothing to Disclose: Deborah S. Bondi, John M. Burke, Jacintha S. Cauffield, Shannon W. Finks, Caitlin M. Gibson,
Leslie A. Hamilton, Brian K. Irons, Emily M. Scopelliti, Curtis L. Smith, Kevin M. Sowinski, Dustin D. Spencer,
Sheila M. Wilhelm, Corey J. Witenko
Reviewer Disclosures
Employee: Jamie Danelo (Allergan through The Medical Affairs Company), Lori Gordon (ViiV Healthcare), Tenille
L. Lawson (Eli Lilly and Co./Lilly Research Laboratories), Hany Mahmoud (Hoffmann-La Roche)
Nothing to Disclose: Elizabeth D. Bentley, Mikel K. Bofenkamp, Wayne E. Bradley, Clement Chung, Jeremy S.
Daniel, Carley E. DeVee, Amber R. Douglass, Wasim S. El Nekidy, Shawn E. Fellows, Ashlee G. Hamel, Tudy M.R.
Hodgman, Kelly C. Hoenig, Gregory J. Hughes, Jennifer E. Katzianer, Kristi W. Kelley, Christopher A. Knefelkamp,
Chengqing Li, Evelina Lin, Claire A. Marten, Aimon C. Miranda, Donald C. Moore, Chelsea G. Owen, Peggy E.
Pace, Elisabeth M. Palmer, Golden L. Peters, Jennifer L. Petrie, Brittany L. Riley, Angela A. Slampak-Cindric, Mary
W. Subramanian, Nisha A. Tahiliani, Azita H. Talasaz, Donna M. Shuler Truoccolo, Mallory L. Turner, Edward
Thomas Van Matre, Tyler A. Vest, Susan R. Winkler, Jessica B. Winter, Eman Elsayed Younis, Min Zhang, Gregory
M. Zumach
ACCP Updates in Therapeutics® 2021: Pharmacotherapy Preparatory Review and Recertification Course
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Acknowledgments
Acknowledgments
Teresa M. Bailey, Pharm.D., BCPS Sheryl Chow, Pharm.D., FCCP, BCPS-AQ Cardiology
Professor Associate Professor of Pharmacy Practice and
College of Pharmacy Administration
Ferris State University College of Pharmacy
Big Rapids, Michigan Western University of Health Sciences
Los Angeles, California
Debra J. Barnette, Pharm.D., BCPS
Assistant Professor of Clinical Pharmacy G. Robert DeYoung, Pharm.D., BCPS
Pharmacy Practice and Administration PGY1 Residency Program Director
Ohio State University College of Pharmacy Mercy Health Saint Mary’s Campus;
Columbus, Ohio Clinical Pharmacist
Mercy Health Physician Partners
Deborah S. Bondi, Pharm.D., BCPS, BCPPS Grand Rapids, Michigan
Clinical Pharmacy Coordinator – Pediatrics
Clinical Pharmacy Specialist – Neonatal Intensive Care Unit Paul Dobesh, Pharm.D., FCCP, BCPS-AQ Cardiology
University of Chicago Medicine, Comer Children’s Hospital Professor of Pharmacy Practice and Science
Chicago, Illinois College of Pharmacy, University of Nebraska Medical Center
Omaha, Nebraska
Lisa Anne Boothby, Pharm.D., BCPS
Clinical Research Pharmacist Anna Legreid Dopp, Pharm.D.
Drug Information Coordinator Clinical Pharmacist
Pharmacy Administration Drug Policy Program
Columbus Regional Healthcare System University of Wisconsin Hospital and Clinics
Columbus, Georgia Madison, Wisconsin
Linda R. Bressler, Pharm.D., BCOP Jennifer M. Dugan, Pharm.D., BCPS
Clinical Associate Professor Primary Care Clinical Pharmacy Specialist
Department of Pharmacy Practice Kaiser Permanente Colorado
College of Pharmacy; Evergreen, Colorado
Director of Regulatory Affairs
Cancer and Leukemia Group B Christopher T. Elder, Pharm.D., BCOP
University of Illinois Assistant Professor of Pharmacy Practice
Chicago, Illinois Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic
University
Mary M. Bridgeman, Pharm.D., BCPS, BCGP West Palm Beach, Florida
Clinical Professor
Ernest Mario School of Pharmacy Shareen El-Ibiary, Pharm.D., FCCP, BCPS
Rutgers University Professor of Pharmacy Practice
Piscataway, New Jersey Department of Pharmacy Practice
Midwestern University College of Pharmacy-Glendale
John M. Burke, Pharm.D., FCCP, BCPS Glendale, Arizona
Professor of Pharmacy Practice
Associate Dean for Postgraduate Education Shannon W. Finks, Pharm.D., FCCP, BCPS
St. Louis College of Pharmacy Professor
St. Louis, Missouri University of Tennessee College of Pharmacy
Clinical Pharmacy Specialist, Cardiology
Jacintha S. Cauffield, Pharm.D., BCPS, CDE, CRPS-A Veterans Affairs Medical Center
Lloyd L. Gregory School of Pharmacy Memphis, Tennessee
Palm Beach Atlantic University
West Palm Beach, Florida Edward F. Foote, Pharm.D., FCCP, BCPS
Professor
Wilkes University
Wilkes-Barre, Pennsylvania
ACCP Updates in Therapeutics® 2021: Pharmacotherapy Preparatory Review and Recertification Course
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Acknowledgments
Caitlin M. Gibson, Pharm.D., BCPS Brian K. Irons, Pharm.D., FCCP, BCACP
Associate Professor Professor of Pharmacy Practice
University of North Texas Health Science Center Texas Tech University Health Sciences Center
Fort Worth, Texas Jerry H. Hodge School of Pharmacy
Lubbock, Texas
Miki Goldwire, MS, Pharm.D.
Assistant Professor William A. Kehoe, Pharm.D., M.A., FCCP, BCPS
Regis University Rueckert-Hartman College for Health Professor, Department of Pharmacy Practice
Professions Director of Student Academic Success
Denver, Colorado T.J. Long School of Pharmacy and Health Sciences
Stockton, California
Linda Gore Martin, Pharm.D., MBA, BCPS
Dean Karen L. Kier, Ph.D., M.Sc., BCPS
Professor, Social and Administrative Pharmacy Director of Assessment and Professor of Clinical Pharmacy
University of Wyoming School of Pharmacy Ohio Northern University
Laramie, Wyoming Ada, Ohio
Leslie A. Hamilton, Pharm.D., FCCP, BCPS, BCCCP Mary Ann Kliethermes, Pharm.D.
Associate Professor Associate Professor
University of Tennessee Health Science Center Chicago College of Pharmacy
Department of Clinical Pharmacy and Translational Science; Midwestern University
Neurocritical Care Clinical Specialist Downers Grove, Illinois
University of Tennessee Medical Center
Knoxville, Tennessee Judith Kristeller, Pharm.D., BCPS
Associate Professor
Dana Hammer, Ph.D., Pharm.D. Wilkes University
Senior Lecturer and Director of Teaching Certificate Wilkes-Barre, Pennsylvania
Program in Pharmacy Education
Department of Pharmacy Kelly C. Lee, Pharm.D., MAS, BCPP
University of Washington Associate Professor of Clinical Pharmacy
Seattle, Washington Associate Dean for Assessment and Accreditation
Skaggs School of Pharmacy and Pharmaceutical Sciences
Ila M. Harris, Pharm.D., FCCP, BCPS University of California San Diego
Associate Professor La Jolla, California
Department of Family Medicine and Community Health
University of Minnesota; Jamie L. McConaha, Pharm.D., BCACP
Bethesda Family Medicine Assistant Professor of Pharmacy Practice
St. Paul, Minnesota Duquesne University Mylan School of Pharmacy
Pittsburgh, Pennsylvania
Brian A. Hemstreet, Pharm.D., FCCP, BCPS
Assistant Dean for Student Affairs Karen J. McConnell, Pharm.D., FCCP, BCPS-AQ
Associate Professor Cardiology
Regis University School of Pharmacy Clinical Pharmacy Specialist
Rueckert-Hartman College for Health Professions Cardinal Health;
Denver, Colorado Clinical Associate Professor
University of Colorado Skaggs School of Pharmacy
Tudy M.R. Hodgman, Pharm.D., FCCM, BCPS Denver, Colorado
Associate Professor of Pharmacy Practice
Clinical Coordinator/Critical Care Specialist John McGlew, M.A.
Northwest Community Hospital Director, Government Affairs
Arlington Heights, Illinois American College of Clinical Pharmacy
Washington, D.C.
Lisa C. Hutchison, Pharm.D., MPH, FCCP, BCPS
Professor Ashley H. Meredith, Pharm.D., BCPS, BCACP, CDE
Department of Pharmacy Practice Clinical Associate Professor
University of Arkansas for Medical Sciences Purdue University, Department of Pharmacy Practice;
College of Pharmacy Clinical Pharmacy Specialist – Ambulatory Care
Little Rock, Arkansas Eskenazi Health
West Lafayette, Indiana
ACCP Updates in Therapeutics® 2021: Pharmacotherapy Preparatory Review and Recertification Course
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