2019 TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection

55 Pages·2019·5.73 MB·English

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TMPRSS2 contributes to virus spread and immunopathology in the
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airways of murine models after coronavirus infection
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Naoko Iwata-Yoshikawaa†, Tadashi Okamurab,c†, Yukiko Shimizub, Hideki Hasegawaa,
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Makoto Takedad, and Noriyo Nagataa#
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aDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan;
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bDepartment of Laboratory Animal Medicine, Research Institute, National Center for
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Global Health and Medicine (NCGM), Tokyo, Japan; cSection of Animal Models,
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Department of Infectious Diseases, Research Institute National Center for Global Health
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and Medicine, Tokyo, Japan; dDepartment of Virology III, National Institute of Infectious
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Diseases, Tokyo, Japan
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Running head: Role of TMPRSS2 in coronavirus infection in vivo
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JVI Accepted Manuscript Posted Online 9 January 2019
J. Virol. doi:10.1128/JVI.01815-18
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

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#Address correspondence to Noriyo Nagata,