2019 Three Amino Acid Changes In Avian Coronavirus Spike Protein Allows Binding To Kidney Tissue

29 Pages·2019·2.21 MB·English

Three Amino Acid Changes In Avian Coronavirus Spike Protein Allows Binding To
1

Kidney Tissue
2

3

Running title: Three amino acids in IBV spike alters receptor tropism
4

5

Kim M. Bouwman1 *, Lisa M. Parsons2, Alinda J. Berends1, Robert P. de Vries3, John F.
6

Cipollo2, Monique H. Verheije1 *
7

8

1 Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht
9

University, Utrecht, the Netherlands.
10

2 Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring,
11

Maryland, United States.
12

3 Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical
13

Sciences, Utrecht University, Utrecht, The Netherlands
14

15

Corresponding authors:
K.M. Bouwman