2019 Small molecule antiviral _-D-_ _i_N__i__ _sup_4__sup__ -hydroxycytidine inhi

39 Pages·2019·1.93 MB·English

1

Small molecule antiviral β-D-N4-hydroxycytidine inhibits a proofreading-intact
1

coronavirus with a high genetic barrier to resistance
2

Maria L. Agostini1, Andrea J. Pruijssers2, James D. Chappell2, Jennifer Gribble1, Xiaotao Lu2,
3

Erica L. Andres2, Gregory R. Bluemling3, Mark A. Lockwood3, Timothy P. Sheahan4, Amy C.
4

Sims4, Michael G. Natchus3, Manohar Saindane3, Alexander A. Kolykhalov3, George R.
5

Painter3,5, Ralph S. Baric4, Mark R. Denison1,2
6

7

1Department of Pathology, Microbiology, and Immunology , Vanderbilt University School of
8

Medicine, Nashville, TN, 2 Department of Pediatrics, Vanderbilt University School of Medicine,
9

Nashville, TN, 3 Emory Institute for Drug Development, Emory University, Atlanta, GA,
10

4Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
11

5Department of Pharmacology and Chemical Biology, Emory University School of Medicine,
12

Atlanta, GA
13

14

*Corresponding author: Mark R. Denison
15

E-mail: