2019 Identification and characterization of a human coronavirus 229E nonstructural protein 8-associated RNA 3_-terminal

48 Pages·2019·1.96 MB·English

Revised manuscript (JVI00291-19) for publication in the Journal of Virology
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Identification and characterization of a human coronavirus 229E
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nonstructural protein 8-associated RNA 3'-terminal adenylyltransferase activity
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Jana Tvarogová,a Ramakanth Madhugiri,a Ganesh Bylapudi,a Lyndsey J. Ferguson,b
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Nadja Karl,a,b John Ziebuhra,b#
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aInstitute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany
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bCentre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences,
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Queen's University Belfast, Belfast, United Kingdom
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Running Head: RNA adenylyltransferase activity of coronavirus nsp8
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Keywords
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RNA virus, coronavirus, replication, nsp8, ribonucleotidylyl transferase, RNA 3'-terminal
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adenylyltransferase, poly(A) tail
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# Address correspondence to John Ziebuhr,