2019 Fitness barriers limit reversion of a proofreading-deficient coronavirus

38 Pages·2019·2.24 MB·English

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Fitness barriers limit reversion of a proofreading-deficient coronavirus
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Kevin W. Graepel1,3, Maria L. Agostini1,3, Xiaotao Lu2, Nicole R. Sexton4, and Mark R.
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Denison1,2,3#
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1Department of Pathology, Microbiology, and Immunology; 2Department of Pediatrics;
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3Vanderbilt Institute for Infection, Immunology and Inflammation (VI4), Vanderbilt University
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Medical Center, Nashville, TN, USA. 4Department of Microbiology, Immunology, and
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Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University,
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Fort Collins, CO, USA.
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#Address correspondence to