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2019 Analysis of coronavirus temperature-sensitive mutants reveals an interplay between the macrodomain and papain-like PDF

46 Pages·2019·2.06 MB·English
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Preview 2019 Analysis of coronavirus temperature-sensitive mutants reveals an interplay between the macrodomain and papain-like

1 Analysis of coronavirus temperature-sensitive mutants reveals an interplay 1 between the macrodomain and papain-like protease 2 impacting replication and pathogenesis 3 4 Xufang Deng1, Robert C. Mettelman1, Amornrat O’Brien1, John A. Thompson1, Timothy 5 E. O’Brien2, and Susan C. Baker1,a 6 1Department of Microbiology and Immunology, Loyola University Chicago, 7 Stritch School of Medicine, Maywood, IL 60153 8 2Department of Mathematics and Statistics, Loyola University Chicago, 9 Chicago, IL 60660 10 11 12 aCorresponding author: 13 Susan C. Baker, PhD 14

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