2019 Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory S

63 Pages·2019·6.01 MB·English

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Acute respiratory infection in human dipeptidyl peptidase 4-transgenic
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mice infected with Middle East respiratory syndrome coronavirus
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Naoko Iwata-Yoshikawa,a† Tadashi Okamura,a,b,c† Yukiko Shimizu,b Osamu Kotani,d
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Hironori Sato,d Hanako Sekimukai,a,e Shuetsu Fukushi,f Tadaki Suzuki,a Yuko Sato,a
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Makoto Takeda,g Masato Tashiro,h Hideki Hasegawa,a and Noriyo Nagataa#
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aDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan;
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bDepartment of Laboratory Animal Medicine, Research Institute, National Center for
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Global Health and Medicine (NCGM), Tokyo, Japan; cSection of Animal Models,
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Department of Infectious Diseases, Research Institute National Center for Global Health
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and Medicine, Tokyo, Japan; dLaboratory of Viral Genomics, Pathogen Genomics Center,
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National Institute of Infectious Diseases, Tokyo, Japan; eDepartment of Tissue Physiology,
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Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan;
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fDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan;
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gDepartment of Virology III, National Institute of Infectious Diseases, Tokyo, Japan;
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hInfluenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
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Running head: A transgenic mouse model of MERS-CoV
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#Address correspondence to Noriyo Nagata,