2018 The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

27 Pages·2018·10.16 MB·English

RESEARCH ARTICLE
The papain-like protease determines a
virulence trait that varies among members of
the SARS-coronavirus species

Daniela NiemeyerID1,2,3, Kirstin Mo¨sbauer1, Eva M. KleinID2, Andrea Sieberg1,2, Robert
C. Mettelman4, Anna M. Mielech4, Ronald DijkmanID5,6, Susan C. Baker4,
Christian Drosten1,2,3☯*, Marcel A. Mu¨llerID1,2,3☯*

1 Institute of Virology, Charite´-Universita¨tsmedizin Berlin, corporate member of Freie Universita¨t Berlin,
Humboldt-Universita¨t zu Berlin, and Berlin Institute of Health, Berlin, Germany, 2 Institute of Virology,
University of Bonn Medical Centre, Bonn, Germany, 3 German Centre for Infection Research, associated
partner Charite´, Berlin, Germany, 4 Department of Microbiology and Immunology, Loyola University of
Chicago, Maywood, IL, United States of America, 5 Institute of Virology and Immunology, Bern &
Mittelha¨usern, Switzerland, 6 Department of Infectious Diseases and Pathobiology, University of Bern, Bern,
Switzerland

☯ These authors contributed equally to this work.
*