2018 The endonucleolytic RNA cleavage function of nsp1 of Middle East respiratory syndrome coronavirus promotes the prod

46 Pages·2018·2.28 MB·English

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The endonucleolytic RNA cleavage function of nsp1 of Middle East respiratory syndrome
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coronavirus promotes the production of infectious virus particles in specific human cell
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lines
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Keisuke Nakagawa1, Krishna Narayanan1, Masami Wada1, Vsevolod L. Popov2,
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Maria Cajimat2, Ralph S. Baric7 and Shinji Makino1,3,4,5,6,#
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Department of Microbiology and Immunology1, Department of Pathology2, Center for
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Biodefense and Emerging Infectious Diseases3, UTMB Center for Tropical Diseases4, Sealy
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Center for Vaccine Development5, and The Institute for Human Infections and Immunity6, The
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University of Texas Medical Branch, Galveston, Texas, USA, and Department of Epidemiology,
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Department of Microbiology and Immunology, School of Medicine, University of North
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Carolina at Chapel Hill7
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Running title: MERS-CoV nsp1 affects virus assembly efficiency
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#: Corresponding author: Shinji Makino
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Corresponding author’s Mailing Address: 4.142E Medical Research Building 301 University
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Boulevard, Galveston, Texas 77555-1019
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Tel/Fax: [phone]
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E-mail: