2017 Identification of residues controlling restriction versus enhancing activities of IFITM proteins on the entry of hu

44 Pages·2017·3.03 MB·English

1

1

2

Identification of residues controlling restriction versus enhancing activities of IFITM
3

proteins on the entry of human coronaviruses
4

5

Xuesen Zhao1,2*, Mohit Sehgal2, Zhifei Hou1, Junjun Cheng2, Sainan Shu2, 3, Shuo Wu2, Fang
6

Guo2, Sylvain J. Le Marchand5, Hanxin Lin4, Jinhong Chang2 and Ju-Tao Guo2*
7

8

9

1Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
2Baruch S.
10

Blumberg Institute, Hepatitis B Foundation, 3805 Old Easton Road, Doylestown, PA 18902.
11

3Department of Pediatrics, Tongji Hospital, Tongji medical college, Huazhong University of
12

Science and Technology, Wuhan 430030, China. 4Department of Pathology and Laboratory
13

Medicine, Western University, 1151 Richmond Street, London, Ontario, Canada. 5Department of
14

Biology, Drexel University, Philadelphia, Pennsylvania, USA.
15

16

Running Title: IFITMs modulate human coronavirus entry
17

18

* Corresponding author’s mailing address:
19

Xuesen Zhao, Beijing Ditan Hospital, Capital Medical University, Beijing, China. E-mail:
20