2017 Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections

40 Pages·2017·7.64 MB·English

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Glycan shield and fusion activation of a deltacoronavirus
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spike glycoprotein fine-tuned for enteric infections
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Xiaoli Xiong1, M. Alejandra Tortorici2,3, Joost Snijder1, Craig Yoshioka4, Alexandra C.
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Walls1, Wentao Li5, Andrew T. McGuire6, Félix A. Rey2,3, Berend-Jan Bosch5 and David
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Veesler1*.
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1Department of Biochemistry, University of Washington, Seattle, Washington 98195,
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USA.
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2Institut Pasteur, Unité de Virologie Structurale, Paris, France.
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3CNRS UMR 3569 Virologie, Paris, France.
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4Department of Biomedical Engineering, Oregon Health and Science University,
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Portland, OR 97201, USA.
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5Virology Division, Department of Infectious Diseases and Immunology, Faculty of
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Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.
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6Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center,
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1100 Fairview Ave. N. P.O. Box 19024 Seattle, WA 98109, USA
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*Correspondence: