RESEARCH ARTICLE Discovery of a rich gene pool of bat SARS- related coronaviruses provides new insights into the origin of SARS coronavirus Ben Hu1☯, Lei-Ping Zeng1☯, Xing-Lou Yang1☯, Xing-Yi Ge1, Wei Zhang1, Bei Li1, Jia- Zheng Xie1, Xu-Rui Shen1, Yun-Zhi Zhang2,3, Ning Wang1, Dong-Sheng Luo1, Xiao- Shuang Zheng1, Mei-Niang Wang1, Peter Daszak4, Lin-Fa Wang5, Jie Cui1*, Zheng- Li Shi1* 1 CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases of Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, 2 Yunnan Institute of Endemic Diseases Control and Prevention, Dali, China, 3 Dali University, Dali, China, 4 EcoHealth Alliance, New York, New York, United States of America, 5 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore ☯ These authors contributed equally to this work. *