2016 Mutagenesis of S-adenosyl-L-methionine-binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Diff

34 Pages·2016·5 MB·English

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Mutagenesis of S-adenosyl-L-methionine-binding Residues in
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Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing
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Requirements for Genome Translation and Resistance to Innate
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Immunity
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James Brett Case,a,b Alison W. Ashbrook,b,c Terence S. Dermody,a,b,c and Mark R. Denisona,b,c*
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Departments of Pathology, Microbiology, and Immunologya and Pediatricsc and Elizabeth B.
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Lamb Center for Pediatric Research,b Vanderbilt University Medical Center, Nashville,
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Tennessee, USA
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*Corresponding author: Mark R. Denison
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