2016 Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins

42 Pages·2016·1.39 MB·English

Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins
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Xiuyuan Ou1&, Wangliang Zheng1&, Yiwei Shan1, Zhixia Mu1, Samuel R. Dominguez2, Kathryn
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V. Holmes3, and Zhaohui Qian1
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MOH Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese
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Academy of Medical Sciences and Peking Union Medical College1, Beijing, 100176, China;
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Department of Pediatrics2, Department of Microbiology3, University of Colorado School of
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Medicine, Aurora, CO 80045
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Key words: coronavirus spike glycoprotein, coronavirus fusion peptide, coronavirus membrane
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fusion, MERS-CoV entry, SARS-CoV, MHV
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Running title: Fusion peptide of spike protein of betacoronavirus
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& XO and WZ contributed equally to this study.
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#Address correspondence to Zhaohui Qian,