2016 Extensive positive selection drives the evolution of non-structural proteins in lineage C Betacoronaviruses

40 Pages·2016·1.47 MB·English

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Extensive positive selection drives the evolution of non-structural proteins in lineage C
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Betacoronaviruses
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Diego Fornia*, Rachele Cagliania, Alessandra Mozzia, Uberto Pozzolia, Nasser Al-Daghrib,c, Mario
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Clericid,e, Manuela Sironia
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a Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy;
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b Biomarker research program, Biochemistry Department, College of Science, King Saud
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University, Riyadh, Kingdom of Saudi Arabia (KSA);
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c Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of
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science, King Saud University, Riyadh, KSA;
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d Department of Physiopathology and Transplantation, University of Milan, Milan, Italy;
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e Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy.
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Running Head: Positive Selection at MERS-CoV non-structural proteins
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*Address for correspondence to Diego Forni,