2016 Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facil

47 Pages·2016·5.88 MB·English

Title: Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an
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Important Surface Attachment Factor Facilitating the Entry of the Middle East
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Respiratory Syndrome Coronavirus (MERS-CoV)
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Che-Man Chan1,2*, Hin Chu1,2*, Yixin Wang2, Bosco Ho-Yin Wong2, Xiaoyu Zhao2, Jie
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Zhou1,2, Dong Yang2, Sze Pui Leung2, Jasper Fuk-Woo Chan1,2,3,4, Man-Lung Yeung1,2,
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Jinghua Yan5, Guangwen Lu5, George Fu Gao5, Kwok-Yung Yuen1,2,3,4,6#.
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Affiliations: 1 State Key Laboratory of Emerging Infectious Diseases; 2 Department of
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Microbiology; 3 Research Centre of Infection and Immunology; 4 Carol Yu Centre for
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Infection; The University of Hong Kong, Hong Kong Special Administrative Region,
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China; 5 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of
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Microbiology, Chinese Academy of Sciences, Beijing 100101, China; 6 The Collaborative
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Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang
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University, Hangzhou, China.
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* C.-M.C. and H.C. contributed equally to this study.
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Running title: CEACAM5 Facilitates MERS-CoV Entry
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Word count: Text: 5845. Abstract: 231.
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#Correspondence: Kwok-Yung Yuen, State Key Laboratory of Emerging Infectious
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Diseases, Carol Yu Centre for Infection, Department of Microbiology, The University of
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Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong Special
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Administrative Region, China. Tel: [phone]. Fax: [phone]. Email:
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