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2015 Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-b PDF

9 Pages·2015·0.61 MB·English
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Preview 2015 Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-b

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus Xiaojuan Guo,1* Yao Deng,1* Hong Chen,1* Jiaming Lan,1,2 Wen Wang,1 Xiaohui Zou,1 Tao Hung,1 Zhuozhuang Lu1 and Wenjie Tan1 1Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, and 2Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, China doi:10.1111/imm.12462 Received 26 November 2014; revised 2 March 2015; accepted 9 March 2015. *These authors contributed equally to this article. Correspondence: Wenjie Tan and Zhuozhu- ang Lu, Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, 155 Changbai Road, ChangPing Dis- trict, Beijing 102206, China Emails:

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