2015 Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1

42 Pages·2015·8.91 MB·English

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Identification of the Receptor Binding Domain of the Spike Glycoprotein of Human
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Betacoronavirus HKU1.
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Zhaohui Qian 1 &#, Xiuyuan Ou1&, Luiz Gustavo Bentim Góes2*, Christina Osborne2,
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Anna Castano3, Kathryn V. Holmes3, and Samuel R. Dominguez2#
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MOH Key laboratory, Institute of Pathogen Biology, Chinese Academy of Medical
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Science1, Departments of Pediatrics 2 and Microbiology 3 , University of Colorado
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School of Medicine, Aurora, Colorado.
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Key words: human betacoronavirus HKU1, betacoronavirus receptor binding domain,
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human betacoronavirus HKU1 neutralizing monoclonal antibodies, primary human
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tracheal and bronchial epithelial cells, coronavirus evolution, betacoronavirus spike
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protein function
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Running title: Receptor-binding domain of human coronavirus HKU1
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& ZQ and XO contributed equally to this study.
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#Address correspondence to Samuel R. Dominguez,
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