2015 A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coron

16 Pages·2015·1.75 MB·English

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Title: A single point mutation creating a furin cleavage site in the spike protein
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renders porcine epidemic diarrhea coronavirus trypsin-independent for cell
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entry and fusion.
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Wentao Lia,b, Oliver Wichta, Frank J.M. van Kuppevelda, Qigai Heb, Peter J.M.
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Rottiera and Berend-Jan Boscha#
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Virology Division, Department of Infectious Diseases and Immunology, Faculty of
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Veterinary Medicine, Utrecht University, Utrecht, The Netherlandsa; State Key
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Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong
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Agricultural University, Wuhan, PR Chinab
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Running title (max.54 characters incl. spaces): PEDV S protein activation by furin
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protease
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# Address correspondence to Berend-Jan Bosch,