2014 Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model

43 Pages·2014·0.81 MB·English

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Protein ISGylation delays but does not overcome coronavirus proliferation in a model of
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fulminant hepatitis
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Xue-Zhong Ma1, Agata Bartczak1, Jianhua Zhang1, Wei He1, Itay Shalev1, David Smil2, Limin
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Chen1, Jim Phillips1, Jordan J. Feld3, Nazia Selzner1, Gary Levy1, Ian McGilvray1#
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Multi-Organ Transplant Program, University Health Network, University of Toronto, Toronto,
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Ontario, Canada1; Structural Genomics Consortium, University of Toronto, Toronto, Ontario,
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Canada2; Toronto Centre for Liver Disease, McLaughlin-Rotman Centre for Global Health, Uni-
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versity of Toronto, Toronto, Canada3.
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Short Title: ISGylation is antiviral to Coronavirus
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Word Count: Abstract ( 235 ); Article ( 5,600 )
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#Ian D McGilvray
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11C1250 NCSB Toronto General Hospital
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585 University Avenue
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Toronto, Ontario M5G 2N2
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Phone: [phone]
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Fax: [phone]
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Email: