2013 Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Ag

26 Pages·2013·6.6 MB·English

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Complete protection against SARS-CoV-mediated lethal respiratory disease in aged mice
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by immunization with a mouse adapted virus deleted in E protein
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Craig Fett1, Marta L. DeDiego2, Jose A. Regla-Nava2, Luis Enjuanes2, Stanley Perlman1*
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1Department of Microbiology, University of Iowa, Iowa City 52242, 2Department of Molecular
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and Cell Biology, Centro Nacional de Biotecnologia (CNB-CSIC), Campus Universidad
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Autonoma, Darwin 3, Cantoblanco, 28049 Madrid, Spain
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Corresponding author: Stanley Perlman, MD, PhD, Department of Microbiology, BSB 3-712,
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University
of
Iowa,
IA
52242.
Tele:
319-335-8549,
Fax
319-335-9006,
Stanley-
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