2013 Complete Genome Analysis of Canine Respiratory Coronavirus

1 Pages·2013·0.11 MB·English

Complete Genome Analysis of Canine Respiratory Coronavirus

Seong-in Lim, Sarah Choi, Ji-Ae Lim, Hye-Young Jeoung, Jae-Young Song, R. C. dela Pena, Dong-Jun An

Animal, Plant, and Fisheries Quarantine and Inspection Agency, Anyang, Gyeonggi, Republic of Korea

S.-I.L. and S.C. contributed equally to this article.

The canine respiratory coronavirus (CRCoV) K37 strain of the family Coronaviridae, group 2, was isolated in South Korea. Its
genome was analyzed by nucleotide sequencing and was determined to have 31,029 bp. The small open reading frames situated
between the spike and envelope genes of most of the CRCoV strains (except the CRCoV 4180 strain) were found to encode three
nonstructural proteins (4.9 kDa, 2.7 kDa, and 12.8 kDa), while those of bovine coronavirus (BCoV) encode another three non-
structural proteins (4.9 kDa, 4.8 kDa, and 12.7 kDa) and those of a recently isolated bovine respiratory coronavirus (BRCoV)
were found to encode only two nonstructural proteins (4.9 kDa and 12.7 kDa). The differences in the genes encoding these small
nonstructural proteins may be associated with the emergence of highly similar viruses in different hosts.

Received 5 November 2012 Accepted 19 November 2012 Published 31 January 2013

Citation Lim S-I, Choi S, Lim J-A, Jeoung H-Y, Song J-Y, dela Pena RC, An D-J. 2013. Complete genome analysis of canine respiratory coronavirus. Genome Announc. 1(1):
e00093-12. doi:10.1128/genomeA.00093-12.

Copyright © 2013 Lim et al. This is an open-access article distributed under the terms of the Attribution 3.0 Unported Creative Commons License.

Address correspondence to Dong-Jun An,