2005 Croup Is Associated with the Novel Coronavirus NL63 PDF
Preview 2005 Croup Is Associated with the Novel Coronavirus NL63
Croup Is Associated with the Novel Coronavirus NL63 Lia van der Hoek1*, Klaus Sure2, Gabriele Ihorst3, Alexander Stang2, Krzysztof Pyrc1, Maarten F. Jebbink1, Gudula Petersen4, Johannes Forster5, Ben Berkhout1, Klaus U¨ berla2 1 Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, 2 Department of Molecular and Medical Virology, Ruhr-University Bochum, Bochum, Germany, 3 Center for Clinical Trials and Institute of Medical Biometry and Medical Informatics, University Hospital, Freiburg, Germany, 4 Wyeth Pharma, Mu¨nster, Germany, 5 St. Josefs Hospital, Freiburg, Germany Competing Interests: The authors have declared that no competing interests exist. Author Contributions: KS, GP, BB, and KU¨ designed the study. KS, AS, KP, MFJ, and KU¨ performed the experiments. LV and GI analyzed the data. LV and BB contributed to writing the paper. Academic Editor: Malik Peiris, University of Hong Kong, China Citation: van der Hoek L, Sure K, Ihorst G, Stang A, Pyrc K, et al. (2005) Croup is associated with the novel coronavirus NL63. PLoS Med 2(8): e240. Received: March 16, 2005 Accepted: May 27, 2005 Published: August 23, 2005 DOI: 10.1371/journal.pmed.0020240 Copyright: � 2005 van der Hoek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abbreviations: HCoV-NL63, human coronavirus NL63; INF, influenza virus; LRTI, lower respiratory tract infection; NPS, nasopharyngeal secretion; PIV, parainfluenza virus; PRI.DE, Paediatric Respiratory Infection in Germany; RSV, respiratory syncytial virus *To whom correspondence should be addressed. E-mail:
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