2004 Molecular biology of severe acute respiratory syndrome coronavirus PDF
Preview 2004 Molecular biology of severe acute respiratory syndrome coronavirus
Molecular biology of severe acute respiratory syndrome coronavirus John Ziebuhr The worldwide epidemic of severe acute respiratory syndrome (SARS) in 2003 was caused by a novel coronavirus called SARS-CoV. Coronaviruses and their closest relatives possess extremely large plus-strand RNA genomes and employ unique mechanisms and enzymes in RNA synthesis that separate them from all other RNA viruses. The SARS epidemic prompted a variety of studies on multiple aspects of the coronavirus replication cycle, yielding both rapid identification of the entry mechanisms of SARS-CoV into host cells and valuable structural and functional information on SARS-CoV proteins. These recent advances in coronavirus research have important implications for the development of anti-SARS drugs and vaccines. Addresses Institute of Virology and Immunology, University of Wu¨ rzburg, Versbacher Str. 7, 97078 Wu¨ rzburg, Germany e-mail:
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