IFMBE Proceedings Volume 28 Series Editor: R. Magjarevic The International Federation for Medical and Biological Engineering, IFMBE, is a federation of national and transnational organizations representing internationally the interests of medical and biological engineering and sciences. The IFMBE is a non-profit organization fostering the creation, dis- semination and application of medical and biological engineering knowledge and the management of technology for improved health and quality of life. Its activities include participation in the formulation of public policy and the dissemination of information through publications and forums. Within the field of medical, clinical, and biological engineering, IFMBE’s aims are to encourage research and the application of knowledge, and to disseminate information and promote collaboration. The objectives of the IFMBE are scientific, technological, literary, and educational. 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Krishnan, Secretary-General: Ratko Magjarevic http://www.ifmbe.org Previous Editions: IFMBE Proceedings BIOMAG2010, “17th International Conference on Biomagnetism Advances in Biomagnetism – Biomag2010”, Vol. 28, 2010, Dubrovnik, Croatia, CD IFMBE Proceedings ICDBME 2010, “The Third International Conference on the Development of Biomedical Engineering in Vietnam”, Vol. 27, 2010, Ho Chi Minh City, Vietnam, CD IFMBE Proceedings MEDITECH 2009, “International Conference on Advancements of Medicine and Health Care through Technology”, Vol. 26, 2009, Cluj-Napoca, Romania, CD IFMBE Proceedings WC 2009, “World Congress on Medical Physics and Biomedical Engineering”, Vol. 25, 2009, Munich, Germany, CD IFMBE Proceedings SBEC 2009, “25th Southern Biomedical Engineering Conference 2009”, Vol. 24, 2009, Miami, FL, USA, CD IFMBE Proceedings ICBME 2008, “13th International Conference on Biomedical Engineering” Vol. 23, 2008, Singapore, CD IFMBE Proceedings ECIFMBE 2008 “4th European Conference of the International Federation for Medical and Biological Engineering”, Vol. 22, 2008, Antwerp, Belgium, CD IFMBE Proceedings BIOMED 2008 “4th Kuala Lumpur International Conference on Biomedical Engineering”, Vol. 21, 2008, Kuala Lumpur, Malaysia, CD IFMBE Proceedings NBC 2008 “14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics”, Vol. 20, 2008, Riga, Latvia, CD IFMBE Proceedings APCMBE 2008 “7th Asian-Pacific Conference on Medical and Biological Engineering”, Vol. 19, 2008, Beijing, China, CD IFMBE Proceedings CLAIB 2007 “IV Latin American Congress on Biomedical Engineering 2007, Bioengineering Solution for Latin America Health”, Vol. 18, 2007, Margarita Island, Venezuela, CD IFMBE Proceedings ICEBI 2007 “13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography”, Vol. 17, 2007, Graz, Austria, CD IFMBE Proceedings MEDICON 2007 “11th Mediterranean Conference on Medical and Biological Engineering and Computing 2007”, Vol. 16, 2007, Ljubljana, Slovenia, CD IFMBE Proceedings BIOMED 2006 “Kuala Lumpur International Conference on Biomedical Engineering”, Vol. 15, 2004, Kuala Lumpur, Malaysia, CD IFMBE Proceedings WC 2006 “World Congress on Medical Physics and Biomedical Engineering”, Vol. 14, 2006, Seoul, Korea, DVD IFMBE Proceedings BSN 2007 “4th International Workshop on Wearable and Implantable Body Sensor Networks”, Vol. 13, 2006, Aachen, Germany IFMBE Proceedings ICBMEC 2005 “The 12th International Conference on Biomedical Engineering”, Vol. 12, 2005, Singapore, CD IFMBE Proceedings Vol. 28 Selma Supek • Ana Sušac (Eds.) 17th International Conference on Biomagnetism Advances in Biomagnetism – Biomag2010 March 28 – April 1, 2010 Dubrovnik, Croatia 123 Editors Selma Supek University of Zagreb Faculty of Science Dept. of Physics Bijenicka cesta 32 10000 Zagreb Croatia E-mail: [email protected] Ana Sušac University of Zagreb Faculty of Science Dept. of Physics Bijenicka cesta 32 10000 Zagreb Croatia E-mail: [email protected] ISSN 1680-0737 ISBN 978-3-642-12196-8 e-ISBN 978-3-642-12197-5 DOI 10.1007/978-3-642-12197-5 Library of Congress Control Number: 2010923826 © International Federation for Medical and Biological Engineering 2010 This work is subject to copyright. 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Ltd., Chennai, India. Cover Design: deblik, Berlin Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com Foreword 40th anniversary of "medical uses of SQUID" It is my great pleasure and honor to invite you to the 17th International Conference on Biomagnetism – Biomag2010 held in Dubrovnik, Croatia from Sunday, March 28 through Thursday, April 1, 2010. The interdisciplinary field of biomagnetism includes dynamic and evolving SQUID-based technologies offering advanced real-time methods for noninvasive assessments of magnetic signals from the brain, heart and other organs as well as a range of modeling, mathematical and computational methods for functional source localization approaches. Excellent spatial resolution and unique, millisecond, temporal resolution of biomagnetic techniques allow insights into cortical neurodynamics and neurobiological basis of the human brain as well as assessment of heart and other organs functions in health and disease. Biomag2010 will be a great opportunity for an exchange of ideas and presentation of the latest developments in instrumentation, modeling approaches, basic and clinical biomedical studies. We are particularly proud to announce the celebration of the 40th anniversary of the first SQUID-based MCG measurements published on April 1, 1970. Since then ''medical uses of SQUID'' were dynamic and growing, including the most recent developments, in combination with a low field MRI, toward a ''direct neuronal imaging''. Dubrovnik, the host city of the Biomag2010, a jewel on the Adriatic, will be a superb and stimulating setting for both scientific and social aspects of this meeting. I am looking forward to hosting you in Dubrovnik, Croatia in spring of 2010. Selma Supek Conference Chair Organization Proceedings Editors Selma Supek Ana Sušac Organizer University of Zagreb, Faculty of Science, Department of Physics Sponsor Croatian Ministry of Science and Technology Endoursed By Croatian Biophysical Society Croatian Cardiac Society International Federation for Medical and Biological Engineering Croatian Institute for Brain Research Croatian Neurological Society Croatian Physical Society Croatian Society for Medical and Biological Engineering Croatian Society for Neuroscience Zagreb Epilepsy Center Croatian Academy of Sciences and Arts Conference Chair Selma Supek Secretary General Ana Sušac International Advisory Board Shinya Kuriki, Chair (Japan) Kazuhiko Atsumi (Japan) Douglas Cheyne (Canada) David Cohen (USA) Luder Decke (Austria) Sergio Erne (Germany) Eric Halgren (USA) Jens Haueisen (Germany) VIII Organization Toivo Katila (Finland) Makoto Kotani (Japan) Gian Luca Romani (Italy) Selma Supek (Croatia) Shoogo Ueno (Japan) Harold Weinberg (Canada) Chris Wood (USA) Scientific Program Committee Selma Supek, Chair (Croatia) Jens Haueisen, Co-chair (Germany) Robert Kraus, Co-chair (USA) Cheryl J. Aine (USA) Sylvain Baillet (USA) Susan Bowyer (USA) Line Garnero† (France) Matti Hämäläinen (USA) Riitta Hari (Finland) Risto Ilmoniemi (Finland) Ole Jensen (The Netherlands) Shinya Kuriki (Japan) Sari Levänen (USA) Markku Mäkijärvi (Finland) Ksenija Marinkovic (USA) Maria Mody (USA) Nobukazu Nakasato (Japan) Yoshio Okada (USA) Christo Pantev (Germany) Andrew Papanicolaou (USA) Gian Luca Romani (Italy) Kensuke Sekihara (Japan) Yoshinori Uchikawa (Japan) Peter Van Leeuwen (Germany) Local Organizing Committee Hrvoje Hećimović Sanja Josef-Golubić Veljko Grilj Ratko Magjarević Marko Miljević Sandra Požar Ana Sušac Nikolina Wolf Marko Banušić, IT Manager Branko Đurđević, IT Manager Mia Vucic, Visual identity Organization IX National MEG Initiative Board – CroMEGin Anto Bagić, Coordinator (USA) Igor Antončić (Rijeka) Vedran Deletis (Split) Vida Demarin (Zagreb) Dražen Domijan (Rijeka) Sanja Hajnšek (Zagreb) Hrvoje Hećimović (Zagreb) Ivica Kostović (Zagreb) Ratko Magjarević (Zagreb) Joško Paladino (Zagreb) Selma Supek (Zagreb) Dinko Štimac (Osijek) Reviewers Cheryl J. Aine (USA) Markku Mäkijärvi (Finland) Sylvain Baillet (USA) Ksenija Marinkovic (USA) Susan Bowyer (USA) Maria Mody (USA) Markus Butz (Germany) John C. Mosher (USA) Chun Kee Chung (South Korea) Nobukazu Nakasato (Japan) Maureen Clerc (France) Yoshio Okada (USA) Paulo R. Fonseca (Italy) Christo Pantev (Germany) Michael Funke (USA) Christos Papadelis (Italy) Matti Hämäläinen (USA) Andrew Papanicolaou (USA) Riitta Hari (Finland) Hubert Preissl (Germany) Richard Henson (UK) Gian Luca Romani (Italy) Jens Haueisen (Germany) Kensuke Sekihara (Japan) Risto Ilmoniemi (Finland) Peter Soros (USA) Sunao Iwaki (Japan) Selma Supek (Croatia) Ole Jensen (The Netherlands) Ana Sušac (Croatia) Blake Johnson (Australia) Norman Tepley (USA) Sung Chan Jun (South Korea) Yoshinori Uchikawa (Japan) Robert Kraus (USA) Peter Van Leeuwen (Germany) Shinya Kuriki (Japan) Tony W. Wilson (USA) Sari Levänen (USA) Filippo Zappasodi (Italy) Jo-Fu Lotus Lin (USA) Johanna Zumer (UK) Burkhard Maess (Germany) Table of Contents 40 Years of SQUIDs in Biomagnetism: Highlights of Heart and Brain Research Forty Years of Magnetocardiology ............................................................ 1 Gerhard Stroink Highlights of 40 Years of SQUID-Based Brain Research and Clinical Applications ............ 9 Cheryl J. Aine Instrumentation: MEG Development of a Whole-Head Child MEG System ........................................... 35 Y. Adachi, M. Miyamoto, J. Kawai, M. Kawabata, M. Higuchi, D. Oyama, G. Uehara, H. Ogata, H. Kado, Y. Haruta, G. Tesan, S. Crain Characteristics of the Helium Circulation System on the 440 CH Vector Type MEG ......... 39 Tsunehiro Takeda, Masayoshi Okamoto, Keishi Katagiri Correction of Disturbances Caused by Temporary and Continuous Head Movements ......... 43 J. Nenonen, J. Nurminen, D. Kiˇci´c, R. Bikmullina, P. Lioumis, V. Jousma¨ki, S. Taulu, L. Parkkonen, M. Putaala, S. Ka¨hk¨onen Video-MEG: Integration of Digital Video to MEG Epilepsy Recordings....................... 47 Juha Wilenius, Andrey Zhdanov, Erik Larismaa, Lauri Parkkonen, Matti Kajola, Jaakko Lyytinen, Antti Ahonen, Ossi Miikkulainen, Jyrki P. Ma¨kela¨, Ritva Paetau Demodulated Effect of SQUID to Magnetic Signal Outside Frequency Bandwidth ............ 50 Daisuke Oyama, Masanori Higuchi, Jun Kawai, Yoshiaki Adachi, Gen Uehara, Hisashi Kado Asymmetric Three-Dimensional Finite Element Analysis of a Magnetically Shielded Room with Access Ports ............................................................................ 54 Broc A. Burke, Solomon G. Diamond Instrumentation: MCG Mapping the Cardiomagnetic Field with 19 Room Temperature Second-Order Gradiometers................................................................................. 58 A. Weis, G. Bison, N. Castagna, S. Cook, A. Hofer, M. Kasprzak, P. Knowles, J.-L. Schenker Towards Clinical MCG with Room-Temperature Sensors ..................................... 62 Gertrud Lembke, Markus Stumpf, Sergio Nicola Ern´e, Georg Bison Improvement of Small-Channel MCG System for Unshielded Environment ................... 66 Mykola M. Budnyk, Oleksandr V. Zakorcheny, Vitaly C. Koshelnyk, Vitaly M. Budnyk, Volodymyr V. Lukashyk, Yuriy D. Minov, Pavlo G. Sutkovyi, Tetyana M. Ryzhenko XII Table of Contents Instrumentation: Multi-modal Integration - MEG, Low-Field MRI, EEG, fMRI, TMS, NIRS Magnetoresistive Hybrid Sensors for Simultaneous Low-Field MRI and Biomagnetic Measurements ................................................................................ 70 Natalia Sergeeva-Chollet, Hadrien Dyvorne, Hedwige Polovy, Myriam Pannetier-Lecoeur, Claude Fermon Safety in Simultaneous Ultra-Low-Field MRI and MEG: Forces Exerted on Magnetizable Objects by Magnetic Fields................................................................... 74 Juhani Dabek, Fredrik Sannholm, Jaakko O. Nieminen, Panu T. Vesanen, Risto J. Ilmoniemi Hybrid MEG-MRI: Geometry and Time Course of Magnetic Fields Inside a Magnetically Shielded Room ............................................................................... 78 P.T. Vesanen, J.O. Nieminen, J. Dabek, R.J. Ilmoniemi Magnetic Resonance Relaxometry at Low and Ultra Low Fields .............................. 82 P. Volegov, M. Flynn, R. Kraus, P. Magnelind, A. Matlashov, P. Nath, T. Owens, H. Sandin, I. Savukov, L. Schultz, A. Urbaitis, V. Zotev, M. Espy Characterizing Cerebral and Extracerebral Components in TMS-Evoked Near-Infrared Spectroscopy Signals.......................................................................... 88 Hanna M¨aki, Tiina Na¨si, Kalle Kotilahti, Ilkka Nissila¨, Pekka Merila¨inen, Risto J. Ilmoniemi Real-Time Spatial Localization System of Brain Regions for TMS Application by Co-registration with fMRI.................................................................... 92 A.S.C. Peres, V.H.O. Souza, E.M. Rodrigues, C.E.G. Salmon, D.B. de Araujo, O. Baffa Multimodal Integration: Constraining MEG Localization with EEG and fMRI................ 97 Richard N.A. Henson MEG Modeling and Spatio-temporal Source Localization Academic Software Toolboxes for the Analysis of MEG Data ................................. 101 S. Baillet, F. Tadel, R.M. Leahy, J.C. Mosher, A. Delorme, S. Makeig, R. Oostenveld, M. Ha¨ma¨la¨inen, S.S. Dalal, J. Zumer, M. Clerc, C.H. Wolters, S. Kiebel, O. Jensen The Adjoint Method for General EEG and MEG Sensor-Based Lead Field Equations......... 105 Th´eodore Papadopoulo, Sylvain Vallagh´e, Maureen Clerc The Symmetric BEM: Bringing in More Variables for Better Accuracy ....................... 109 Maureen Clerc, Alexandre Gramfort, Emmanuel Olivi, Theo Papadopoulo From Classical to Bayesian Estimators in the Interpretation of MEG and EEG ............... 113 Jukka Sarvas, Risto J. Ilmoniemi Skull Thickness versus Mesh Density — A Study on BEM Discretization Error............... 117 Pascal Werner, Matti Stenroos Domain Decomposition for Coupling Finite and Boundary Element Methods in EEG......... 120 Emmanuel Olivi, Maureen Clerc, Th´eodore Papadopoulo
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